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@article{1367185,
author = {Amaro, Mariana and Šachl, Radek and Aydogan, Gokcan and Mikhalyov, Ilya I. and Vácha, Robert and Hof, Martin},
article_location = {WEINHEIM},
article_number = {32},
doi = {http://dx.doi.org/10.1002/anie.201603178},
keywords = {Alzheimer's disease; amyloid beta-peptides; diffusion coefficients; fluorescence spectroscopy; neuroprotectives},
language = {eng},
issn = {1433-7851},
journal = {Angewandte Chemie International Edition},
title = {(GM1) Ganglioside Inhibits beta-Amyloid Oligomerization Induced bySphingomyelin},
url = {http://onlinelibrary.wiley.com/doi/10.1002/anie.201603178/abstract},
volume = {55},
year = {2016}
}
TY - JOUR
ID - 1367185
AU - Amaro, Mariana - Šachl, Radek - Aydogan, Gokcan - Mikhalyov, Ilya I. - Vácha, Robert - Hof, Martin
PY - 2016
TI - (GM1) Ganglioside Inhibits beta-Amyloid Oligomerization Induced bySphingomyelin
JF - Angewandte Chemie International Edition
VL - 55
IS - 32
SP - 9411-9415
EP - 9411-9415
PB - Wiley-V C H VERLAG GMBH
SN - 14337851
KW - Alzheimer's disease
KW - amyloid beta-peptides
KW - diffusion coefficients
KW - fluorescence spectroscopy
KW - neuroprotectives
UR - http://onlinelibrary.wiley.com/doi/10.1002/anie.201603178/abstract
L2 - http://onlinelibrary.wiley.com/doi/10.1002/anie.201603178/abstract
N2 - beta-Amyloid (A beta) oligomers are neurotoxic and implicated in Alzheimer's disease. Neuronal plasma membranes may mediate formation of A beta oligomers in vivo. Membrane components sphingomyelin and GM(1) have been shown to promote aggregation of A beta; however, these studies were performed under extreme, non-physiological conditions. We demonstrate that physiological levels of GM(1), organized in nanodomains do not seed oligomerization of A beta(40) monomers. We show that sphingomyelin triggers oligomerization of A beta(40) and that GM(1) is counteractive thus preventing oligomerization. We propose a molecular explanation that is supported by all-atom molecular dynamics simulations. The preventive role of GM(1) in the oligomerization of A beta(40) suggests that decreasing levels of GM(1) in the brain, for example, due to aging, could reduce protection against A beta oligomerization and contribute to the onset of Alzheimer's disease.
ER -
AMARO, Mariana, Radek ŠACHL, Gokcan AYDOGAN, Ilya I. MIKHALYOV, Robert VÁCHA and Martin HOF. (GM1) Ganglioside Inhibits beta-Amyloid Oligomerization Induced bySphingomyelin. \textit{Angewandte Chemie International Edition}. WEINHEIM: Wiley-V C H VERLAG GMBH, 2016, vol.~55, No~32, p.~9411-9415. ISSN~1433-7851. Available from: https://dx.doi.org/10.1002/anie.201603178.
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