Pre-treatment VD levels and VDR receptors as potential
predictors of occurrence and overall survival in paediatric
patients with solid tumours-a single institution pilot study

J 2016

Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study

BIENERTOVÁ VAŠKŮ, Julie, Klára DRÁBOVÁ, Filip ZLÁMAL, Josef TOMANDL, Michal KÝR et. al.

Základní údaje

Originální název

Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study

Autoři

BIENERTOVÁ VAŠKŮ, Julie (203 Česká republika, domácí), Klára DRÁBOVÁ (203 Česká republika), Filip ZLÁMAL (203 Česká republika, domácí), Josef TOMANDL (203 Česká republika, domácí), Michal KÝR (203 Česká republika), Zbyněk ŠPLÍCHAL (203 Česká republika, domácí) a Jaroslav ŠTĚRBA (203 Česká republika, garant)

Vydání

Tumor Biology, Dordrecht, Springer, 2016, 1010-4283

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.650

Kód RIV

RIV/00216224:14110/16:00092763

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s13277-016-4820-9

UT WoS

000382174500072

Klíčová slova anglicky

Vitamin D; Childhood cancer; Overall survival; VDR; Gene; SNP

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 3. 2017 10:28, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Recently, vitamin D has been recognized as an important player in the immune system, and multiple studies suggested its involvement in cancer, too. The aims of this study were to investigate selected single nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410; A > G), FokI (rs 2228570; C > T), TaqI (rs731236; T > C), ApaI (rs 7975232; C > T) and Cdx-2 (rs11568820; A > G), and to evaluate their possible predictive role for outcomes in patients with paediatric solid tumours. A total of 111 children with paediatric solid tumours were enrolled at the Department of Paediatric Oncology, University Hospital Brno (Brno, Czech Republic) along with a control population of 787 adults; all study subjects were available for genotyping of selected SNPs, and the prediagnostic levels of 25-hydroxycholecalciferol (25(OH)D3) and 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in the cases, too. In FokI, the heterozygote CT genotype was weakly associated with a decreased risk of paediatric solid cancer occurrence 0.82 (0.53-1.28), while the CC genotype was associated with a decreased risk of 0.58 (0.30-1.09), p = 0.09. The 1,25(OH)2D3 prediagnostic levels were indicative of the overall survival in the cases (beta = -0.012, HR 0.988, 95 % CI (0.978-0.998), while higher prediagnostic levels of 1,25(OH)2D3 were associated with a statistically significant increase in overall mortality. We observed multiple effects of the alleles of the investigated polymorphisms and of 1,25(OH)2D3 on overall survival, regardless of the underlying disease.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

LM2011028, projekt VaV

Název: RECETOX ? Národní infrastruktura pro výzkum toxických látek v prostředí

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX Národní infrastruktura pro výzkum toxických látek v prostředí

Přiložené soubory

EL_1367260.pdf

Požádat o autorskou verzi souboru

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Klára DRÁBOVÁ, Filip ZLÁMAL, Josef TOMANDL, Michal KÝR, Zbyněk ŠPLÍCHAL a Jaroslav ŠTĚRBA. Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study. Tumor Biology. Dordrecht: Springer, 2016, roč. 37, č. 7, s. 9209-9219. ISSN 1010-4283. Dostupné z: https://dx.doi.org/10.1007/s13277-016-4820-9.

@article{1367260,
   author = {Bienertová Vašků, Julie and Drábová, Klára and Zlámal, Filip and Tomandl, Josef and Kýr, Michal and Šplíchal, Zbyněk and Štěrba, Jaroslav},
   article_location = {Dordrecht},
   article_number = {7},
   doi = {http://dx.doi.org/10.1007/s13277-016-4820-9},
   keywords = {Vitamin D; Childhood cancer; Overall survival; VDR; Gene; SNP},
   language = {eng},
   issn = {1010-4283},
   journal = {Tumor Biology},
   title = {Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study},
   volume = {37},
   year = {2016}
}

TY  - JOUR
ID  - 1367260
AU  - Bienertová Vašků, Julie - Drábová, Klára - Zlámal, Filip - Tomandl, Josef - Kýr, Michal - Šplíchal, Zbyněk - Štěrba, Jaroslav
PY  - 2016
TI  - Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study
JF  - Tumor Biology
VL  - 37
IS  - 7
SP  - 9209-9219
EP  - 9209-9219
PB  - Springer
SN  - 10104283
KW  - Vitamin D
KW  - Childhood cancer
KW  - Overall survival
KW  - VDR
KW  - Gene
KW  - SNP
N2  - Recently, vitamin D has been recognized as an important player in the immune system, and multiple studies suggested its involvement in cancer, too. The aims of this study were to investigate selected single nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410; A > G), FokI (rs 2228570; C > T), TaqI (rs731236; T > C), ApaI (rs 7975232; C > T) and Cdx-2 (rs11568820; A > G), and to evaluate their possible predictive role for outcomes in patients with paediatric solid tumours. A total of 111 children with paediatric solid tumours were enrolled at the Department of Paediatric Oncology, University Hospital Brno (Brno, Czech Republic) along with a control population of 787 adults; all study subjects were available for genotyping of selected SNPs, and the prediagnostic levels of 25-hydroxycholecalciferol (25(OH)D3) and 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in the cases, too. In FokI, the heterozygote CT genotype was weakly associated with a decreased risk of paediatric solid cancer occurrence 0.82 (0.53-1.28), while the CC genotype was associated with a decreased risk of 0.58 (0.30-1.09), p = 0.09. The 1,25(OH)2D3 prediagnostic levels were indicative of the overall survival in the cases (beta = -0.012, HR 0.988, 95 % CI (0.978-0.998), while higher prediagnostic levels of 1,25(OH)2D3 were associated with a statistically significant increase in overall mortality. We observed multiple effects of the alleles of the investigated polymorphisms and of 1,25(OH)2D3 on overall survival, regardless of the underlying disease.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Klára DRÁBOVÁ, Filip ZLÁMAL, Josef TOMANDL, Michal KÝR, Zbyněk ŠPLÍCHAL a Jaroslav ŠTĚRBA. Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study. \textit{Tumor Biology}. Dordrecht: Springer, 2016, roč.~37, č.~7, s.~9209-9219. ISSN~1010-4283. Dostupné z: https://dx.doi.org/10.1007/s13277-016-4820-9.

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