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@article{1367310,
author = {Indráková, Adéla and Mašlaňová, Ivana and Kováčová, Viera and Doškař, Jiří and Pantůček, Roman},
article_number = {11},
doi = {http://dx.doi.org/10.1515/biolog-2016-0156},
keywords = {Staphylococcus; methicillin-resistant Staphylococcus aureus (MRSA); staphylococcal cassette chromosome; evolution; mobile genetic elements},
language = {eng},
issn = {0006-3088},
journal = {Biologia},
title = {The evolutionary pathway of the staphylococcal cassette chromosome element},
url = {https://www.degruyter.com/view/j/biolog.2016.71.issue-11/biolog-2016-0156/biolog-2016-0156.xml},
volume = {71},
year = {2016}
}
TY - JOUR
ID - 1367310
AU - Indráková, Adéla - Mašlaňová, Ivana - Kováčová, Viera - Doškař, Jiří - Pantůček, Roman
PY - 2016
TI - The evolutionary pathway of the staphylococcal cassette chromosome element
JF - Biologia
VL - 71
IS - 11
SP - 1195-1203
EP - 1195-1203
PB - Springer
SN - 00063088
KW - Staphylococcus
KW - methicillin-resistant Staphylococcus aureus (MRSA)
KW - staphylococcal cassette chromosome
KW - evolution
KW - mobile genetic elements
UR - https://www.degruyter.com/view/j/biolog.2016.71.issue-11/biolog-2016-0156/biolog-2016-0156.xml
L2 - https://www.degruyter.com/view/j/biolog.2016.71.issue-11/biolog-2016-0156/biolog-2016-0156.xml
N2 - The staphylococcal cassette chromosome (SCC) element can carry resistance genes to antibiotics, disinfectants, and heavy metals, contributing to the survival of strains in the environment and causing difficulties in the treatment of staphylococcal infections. Methicillin resistance in staphylococci, which is of particular clinical significance, is encoded by staphylococcal cassette chromosome mec (SCCmec). Despite the importance of the SCC element and description of multiple nucleotide sequences, the information about its origin and evolution is still scarce. Here, we present a phylogenetic analysis of SCC elements that is unique in the use of whole SCC sequences. A phylogenetic tree for a noteworthy number of 81 SCC elements based on global sequence alignment was constructed. The SCC clustering did not reflect the genetic relationships of bacteria containing the SCC elements, but was done according to type, determined by the combination of mec gene complex class and ccr gene complex type. The results emphasise the horizontal gene transfer as a means of spread of SCC elements in bacterial strains. Overall, this study contributes to the understanding of SCC emergence, evolution, and dissemination.
ER -
INDRÁKOVÁ, Adéla, Ivana MAŠLAŇOVÁ, Viera KOVÁČOVÁ, Jiří DOŠKAŘ a Roman PANTŮČEK. The evolutionary pathway of the staphylococcal cassette chromosome element. \textit{Biologia}. Springer, 2016, roč.~71, č.~11, s.~1195-1203. ISSN~0006-3088. Dostupné z: https://dx.doi.org/10.1515/biolog-2016-0156.
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