The Role of microRNA in Ischemic and Hemorrhagic Stroke

J 2017

The Role of microRNA in Ischemic and Hemorrhagic Stroke

LIPKOVÁ, Jolana a Kamil ĎURIŠ

Základní údaje

Originální název

The Role of microRNA in Ischemic and Hemorrhagic Stroke

Název česky

Role microRNA u ischemické a hemoragické cévní mozkové příhody

Autoři

LIPKOVÁ, Jolana (203 Česká republika, garant, domácí) a Kamil ĎURIŠ (203 Česká republika, domácí)

Vydání

Current Drug Delivery, Sharjah, Bentham Science Publishers, 2017, 1567-2018

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Spojené arabské emiráty

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.078

Kód RIV

RIV/00216224:14110/17:00094602

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.2174/1567201813666160919142212

UT WoS

000409883200010

Klíčová slova česky

microRNA, ischemické cévní mozková příhoda, hemoragická cévní mozková příhoda

Klíčová slova anglicky

Central nervous system; embolectomies; hemorrgahic stroke; ischemic stroke; microRNA; thrombolysis

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 3. 2018 13:17, Soňa Böhmová

Anotace

V originále

Background: Stroke is the second leading cause of death worldwide. Understanding of gene expression dynamics could bring new approaches in diagnostics and therapy of stroke. Small noncoding molecules termed "microRNA" represent the most flexible network of gene expression regulators. Method: The aim of this review was to briefly describe the structure and function of microRNA and summarize the current knowledge about the involvement of microRNAs in the pathophysiology of ischemic and hemorrhagic stroke based on both experimental and clinical studies. Results: Numerous profiling studies identified candidate microRNAs and partially described dynamics of their expression after the stroke. However, complex associations of specific microRNAs expression with main clinical characteristics and deeper insight into mechanisms of their regulatory functions are still missing. In this review, we put special emphasis on several microRNA clusters involved in neuroprotection (miR-124, miR-181, miR-21, miR-29, miR-210 and let7). Potential application of microRNAs as biomarkers and diagnostic or therapeutic targets was also discussed. Conclusion: Full understanding of the regulatory mechanisms of the microRNA networks represents a novel direction for stroke research. To date, we do not have effective tools to control pathophysiological processes associated with stroke. Thus the microRNAs have to be considered as a very promising target for future stroke therapies.

Návaznosti

GP14-23773P, projekt VaV

Název: Regulace zánětlivé odpovědi prostřednictvím mikroRNA na experimaentálním modelu subarachnoidálního krvácení

Investor: Grantová agentura ČR, Regulace zánětlivé odpovědi prostřednictvím mikroRNA na experimaentálním modelu subarachnoidálního krvácení

Citovat

LIPKOVÁ, Jolana a Kamil ĎURIŠ. The Role of microRNA in Ischemic and Hemorrhagic Stroke. Current Drug Delivery. Sharjah: Bentham Science Publishers, 2017, roč. 14, č. 6, s. 816-831. ISSN 1567-2018. Dostupné z: https://dx.doi.org/10.2174/1567201813666160919142212.

@article{1367388,
   author = {Lipková, Jolana and Ďuriš, Kamil},
   article_location = {Sharjah},
   article_number = {6},
   doi = {http://dx.doi.org/10.2174/1567201813666160919142212},
   keywords = {Central nervous system; embolectomies; hemorrgahic stroke; ischemic stroke; microRNA; thrombolysis},
   language = {eng},
   issn = {1567-2018},
   journal = {Current Drug Delivery},
   title = {The Role of microRNA in Ischemic and Hemorrhagic Stroke},
   volume = {14},
   year = {2017}
}

TY  - JOUR
ID  - 1367388
AU  - Lipková, Jolana - Ďuriš, Kamil
PY  - 2017
TI  - The Role of microRNA in Ischemic and Hemorrhagic Stroke
JF  - Current Drug Delivery
VL  - 14
IS  - 6
SP  - 816-831
EP  - 816-831
PB  - Bentham Science Publishers
SN  - 15672018
KW  - Central nervous system
KW  - embolectomies
KW  - hemorrgahic stroke
KW  - ischemic stroke
KW  - microRNA
KW  - thrombolysis
N2  - Background: Stroke is the second leading cause of death worldwide. Understanding of gene expression dynamics could bring new approaches in diagnostics and therapy of stroke. Small noncoding molecules termed "microRNA" represent the most flexible network of gene expression regulators. Method: The aim of this review was to briefly describe the structure and function of microRNA and summarize the current knowledge about the involvement of microRNAs in the pathophysiology of ischemic and hemorrhagic stroke based on both experimental and clinical studies. Results: Numerous profiling studies identified candidate microRNAs and partially described dynamics of their expression after the stroke. However, complex associations of specific microRNAs expression with main clinical characteristics and deeper insight into mechanisms of their regulatory functions are still missing. In this review, we put special emphasis on several microRNA clusters involved in neuroprotection (miR-124, miR-181, miR-21, miR-29, miR-210 and let7). Potential application of microRNAs as biomarkers and diagnostic or therapeutic targets was also discussed. Conclusion: Full understanding of the regulatory mechanisms of the microRNA networks represents a novel direction for stroke research. To date, we do not have effective tools to control pathophysiological processes associated with stroke. Thus the microRNAs have to be considered as a very promising target for future stroke therapies.
ER  -

LIPKOVÁ, Jolana a Kamil ĎURIŠ. The Role of microRNA in Ischemic and Hemorrhagic Stroke. \textit{Current Drug Delivery}. Sharjah: Bentham Science Publishers, 2017, roč.~14, č.~6, s.~816-831. ISSN~1567-2018. Dostupné z: https://dx.doi.org/10.2174/1567201813666160919142212.

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