J 2017

Developmental neurotoxicants in human milk: Comparison of levels and intakes in three European countries

ČECHOVÁ, Eliška, Martin SCHERINGER, Marta SEIFERTOVÁ, Ondřej MIKEŠ, Kristýna KROUPOVÁ et. al.

Basic information

Original name

Developmental neurotoxicants in human milk: Comparison of levels and intakes in three European countries

Authors

ČECHOVÁ, Eliška (203 Czech Republic, belonging to the institution), Martin SCHERINGER (756 Switzerland, guarantor, belonging to the institution), Marta SEIFERTOVÁ (203 Czech Republic, belonging to the institution), Ondřej MIKEŠ (203 Czech Republic, belonging to the institution), Kristýna KROUPOVÁ (203 Czech Republic, belonging to the institution), Jan KUTA (203 Czech Republic, belonging to the institution), Joan FORNS (724 Spain), Merete EGGESBO (578 Norway), Ilona QUAAK (528 Netherlands), Marijke DE COCK (528 Netherlands), Margot VAN DE BOR (528 Netherlands), Henrieta PATAYOVA (703 Slovakia), L'ubica MURÍNOVÁ (703 Slovakia) and Anton KOČAN (703 Slovakia, belonging to the institution)

Edition

Science of the Total Environment, AMSTERDAM, Elsevier Science BV, 2017, 0048-9697

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.610

RIV identification code

RIV/00216224:14310/17:00096030

Organization unit

Faculty of Science

DOI

UT WoS

000391897800065

Keywords in English

Developmental neurotoxicity; Daily intakes; Methylmercury; Organochlorine compounds; Pharmacokinetic model

Tags

Změněno: 1/4/2018 09:21, Ing. Nicole Zrilić

Abstract

V originále

Developmental neurotoxicants (DNTs), such as methylmercury (MeHg), polychlorinated biphenyls (PCBs) and selected organochlorine pesticides (OCPs), have gained increasing interest recently due to their possible relation to developmental disorders in children, which are increasing worldwide. We analyzed levels of 14 developmental neurotoxicants in human milk samples from Slovakia (n = 37), the Netherlands (n = 120) and Norway (n = 388). Positive identification for most target analytes was >95% in all samples. In all three countries MeHg was measured for the first time in mother milk. The highest MeHg levels were observed in Norway (39 pg g(-1), ww) with the highest fish consumption. Levels of indicator PCBs (iPCBs, sum of PCB 28, 52, 101, 138, 153 and 180), HCB and DDE + DDT were 2-4 times higher in Slovakia compared to the Netherlands or Norway. The levels of MeHg and organochlorine compounds were used for calculations of weekly or daily intakes (top-down approach) by means of pharmacokinetic modeling. The intakes ranged from 0.014 to 0.142 mu g kg(bw)(-1) week(-1) for MeHg and from 0.043 to 17.4 mu g kg(bw)(-1) day(-1) for organochlotine compounds in all three countries. Intakes of iPCBs exceeded a tolerable daily intake of 10 ng kgbw day(-1) in 16% of the Slovak participants. The top-down estimates were compared with bottom-up intakes based on national dietaty estimates and the results showed good consistency between both approaches, with the bottom-up intakes exceeding the top-down by a factor of maximum 3.8 for iPCBs in the Netherlands and 3.9 for HCB in Slovakia. This confirms that food consumption in all three countries represents the dominant pathway of exposure to these developmental neurotoxicants.

Links

EF15_003/0000469, research and development project
Name: Cetocoen Plus
LM2015051, research and development project
Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR
282957, interní kód MU
Name: DENAMIC - Developmental neurotoxicity assessment of mixtures in children (Acronym: DENAMIC)
Investor: European Union, Cooperation