| ADAMOVSKÝ, Ondřej, Zdena MOOSOVÁ, Michaela PEKAROVÁ, Amrita BASU, Pavel BABICA, Lenka ŠVIHÁLKOVÁ ŠINDLEROVÁ, Lukáš KUBALA a Luděk BLÁHA. Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin. Environmental Science & Technology. WASHINGTON: The American Chemical Society, 2015, roč. 49, č. 20, s. 12457-12464. ISSN 0013-936X. Dostupné z: https://dx.doi.org/10.1021/acs.est.5b02049. |
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@article{1368566,
author = {Adamovský, Ondřej and Moosová, Zdena and Pekarová, Michaela and Basu, Amrita and Babica, Pavel and Švihálková Šindlerová, Lenka and Kubala, Lukáš and Bláha, Luděk},
article_location = {WASHINGTON},
article_number = {20},
doi = {http://dx.doi.org/10.1021/acs.est.5b02049},
keywords = {Immunomodulatory Potency; Microcystin; Cyanobacterial Toxin},
language = {eng},
issn = {0013-936X},
journal = {Environmental Science & Technology},
title = {Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin},
url = {http://pubs.acs.org/doi/abs/10.1021/acs.est.5b02049},
volume = {49},
year = {2015}
}
TY - JOUR
ID - 1368566
AU - Adamovský, Ondřej - Moosová, Zdena - Pekarová, Michaela - Basu, Amrita - Babica, Pavel - Švihálková Šindlerová, Lenka - Kubala, Lukáš - Bláha, Luděk
PY - 2015
TI - Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin
JF - Environmental Science & Technology
VL - 49
IS - 20
SP - 12457-12464
EP - 12457-12464
PB - The American Chemical Society
SN - 0013936X
KW - Immunomodulatory Potency
KW - Microcystin
KW - Cyanobacterial Toxin
UR - http://pubs.acs.org/doi/abs/10.1021/acs.est.5b02049
L2 - http://pubs.acs.org/doi/abs/10.1021/acs.est.5b02049
N2 - Microcystins (MCs) are primarily hepatotoxins produced by cyanobacteria and are responsible for intoxication in humans and animals. There are many incidents of chronic exposure to MCs, which have been attributed to the inappropriate treatment of water supplies or contaminated food. Using RAW 264.7 macrophages, we showed the potency of microcystin-LR (MC-LR) to stimulate production of pro-inflammatory cytokines (tumor necrosis factor alpha and interleukin-6) as a consequence of fast nuclear factor kappa B and nitrogen-activated protein kinase activation. In contrast to other studies, the observed effects were not attributed to the intracellular inhibition of protein phosphatases 1/2A due to lack of specific transmembrane transporters for MCs. However, the MC-LR-induced activation of macrophages was effectively inhibited by a specific peptide that blocks signaling of receptors, which play a pivotal role in the innate immune responses. Taken together, we showed for the first time that MC-LR could interfere with macrophage receptors that are responsible for triggering the above-mentioned signaling pathways. These findings provide an interesting mechanistic explanation of some adverse health outcomes associated with toxic cyanobacteria and MCs.
ER -
ADAMOVSKÝ, Ondřej, Zdena MOOSOVÁ, Michaela PEKAROVÁ, Amrita BASU, Pavel BABICA, Lenka ŠVIHÁLKOVÁ ŠINDLEROVÁ, Lukáš KUBALA a Luděk BLÁHA. Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin. \textit{Environmental Science \&{} Technology}. WASHINGTON: The American Chemical Society, 2015, roč.~49, č.~20, s.~12457-12464. ISSN~0013-936X. Dostupné z: https://dx.doi.org/10.1021/acs.est.5b02049.
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