| PINK, Richard, Bohuslav MELICHAR, Josef TOMANDL, Lenka BLAŽKOVÁ, Peter TVRDÝ a Jana ZAPLETALOVÁ. Salivary neopterin concentrations in patients with cancer of the oral cavity. Pteridines. Berlin: Walter de Gruyter, 2016, roč. 27, 3-4, s. 53-58. ISSN 0933-4807. Dostupné z: https://dx.doi.org/10.1515/pterid-2015-0017. |
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@article{1369451,
author = {Pink, Richard and Melichar, Bohuslav and Tomandl, Josef and Blažková, Lenka and Tvrdý, Peter and Zapletalová, Jana},
article_location = {Berlin},
article_number = {3-4},
doi = {http://dx.doi.org/10.1515/pterid-2015-0017},
keywords = {head and neck cancer; neopterin; saliva},
language = {eng},
issn = {0933-4807},
journal = {Pteridines},
title = {Salivary neopterin concentrations in patients with cancer of the oral cavity},
volume = {27},
year = {2016}
}
TY - JOUR
ID - 1369451
AU - Pink, Richard - Melichar, Bohuslav - Tomandl, Josef - Blažková, Lenka - Tvrdý, Peter - Zapletalová, Jana
PY - 2016
TI - Salivary neopterin concentrations in patients with cancer of the oral cavity
JF - Pteridines
VL - 27
IS - 3-4
SP - 53-58
EP - 53-58
PB - Walter de Gruyter
SN - 09334807
KW - head and neck cancer
KW - neopterin
KW - saliva
N2 - Tumors of the oral cavity are relatively common malignancies with a poor prognosis. Use of both prognostic and predictive biomarkers in saliva represents one approach to improve the management of patients with these cancers. The aim of the present study was to measure salivary neopterin concentrations before and after surgery in patients with oropharyngeal cancer to assess potential use as a biomarker in clinical practice. Salivary neopterin concentration was determined before and after surgery in 16 patients treated for oropharyngeal cancer and compared with 15 healthy volunteers. Salivary neopterin concentrations were significantly higher in patients before surgery compared to the healthy controls. After the surgery, neopterin concentrations decreased significantly, and concentrations in patients and controls were comparable. A significant correlation was observed between the sum of the Community Periodontal Index of Treatment Needs values and salivary neopterin concentrations. In conclusion, tumor removal results in significant decrease of salivary neopterin concentrations. The use of salivary neopterin in diagnosis is compounded by an association with periodontal disease.
ER -
PINK, Richard, Bohuslav MELICHAR, Josef TOMANDL, Lenka BLAŽKOVÁ, Peter TVRDÝ a Jana ZAPLETALOVÁ. Salivary neopterin concentrations in patients with cancer of the oral cavity. \textit{Pteridines}. Berlin: Walter de Gruyter, 2016, roč.~27, 3-4, s.~53-58. ISSN~0933-4807. Dostupné z: https://dx.doi.org/10.1515/pterid-2015-0017.
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