HNSCC Biomarkers Derived from Key Processes of Cancerogenesis

C 2016

HNSCC Biomarkers Derived from Key Processes of Cancerogenesis

RAUDENSKÁ, Martina; Jaromír GUMULEC; Andrew M. FRIBLEY and Michal MASAŘÍK

Basic information

Original name

HNSCC Biomarkers Derived from Key Processes of Cancerogenesis

Authors

RAUDENSKÁ, Martina (203 Czech Republic, belonging to the institution); Jaromír GUMULEC (203 Czech Republic, belonging to the institution); Andrew M. FRIBLEY (840 United States of America) and Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Switzerland, Targeting Oral Cancer, p. 115-160, 46 pp. 2016

Publisher

Springer International Publishing

Other information

Language

English

Type of outcome

Chapter(s) of a specialized book

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Switzerland

Confidentiality degree

is not subject to a state or trade secret

Publication form

electronic version available online

RIV identification code

RIV/00216224:14110/16:00088944

Organization unit

Faculty of Medicine

ISBN

978-3-319-27647-2

Keywords in English

Head and neck squamous cell carcinoma

Abstract

In the original language

Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent aggressive cancers in humans. Well-known risk factors include HPV infection, tobacco smoking, and alcohol consumption. HNSCC overall survival rate is one of the lowest among human malignancies. The poor prognosis of HNSCC often results from late-stage diagnosis, therapeutic resistance, high rates of recurrence, and frequent metastases to lymph nodes. To date, the TNM classification is still the best evaluation of disease progress; however, this method of staging does not pay attention to the molecular basis of tumorigenesis. An improvement in treatment efficacy and diagnostic capabilities will be realized through a better understanding of the pathogenesis and characteristics of HNSCC, a disease that has come to be characterized by confounding heterogeneity. This chapter is focused on molecular markers derived from key processes of cancero-genesis that are involved in metastasis, treatment resistance, avoidance of immune detection, inflammation, induction of angiogenesis, genome instability, dysregulation of cellular energetics, cell death, cancer stem cell biology, and rearrangement of tissues adjacent to the tumor. We will discuss biomarkers identified at different levels of cellular regulation (DNA, RNA, miRNA, and protein markers).

Links

NT14337, research and development project

Name: Studium a charakterizace primárních nádorových buněčných linií spinocelulárních karcinomů v oblasti hlavy a krku a jejich maligní potenciál.

Investor: Ministry of Health of the CR

Cite

RAUDENSKÁ, Martina; Jaromír GUMULEC; Andrew M. FRIBLEY and Michal MASAŘÍK. HNSCC Biomarkers Derived from Key Processes of Cancerogenesis. Online. In Andrew M. Fribley. Targeting Oral Cancer. Switzerland: Springer International Publishing, 2016, p. 115-160. ISBN 978-3-319-27647-2.

@inbook{1370920,
   author = {Raudenská, Martina and Gumulec, Jaromír and Fribley, Andrew M. and Masařík, Michal},
   address = {Switzerland},
   booktitle = {Targeting Oral Cancer},
   editor = {Andrew M. Fribley},
   keywords = {Head and neck squamous cell carcinoma},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Switzerland},
   isbn = {978-3-319-27647-2},
   pages = {115-160},
   publisher = {Springer International Publishing},
   title = {HNSCC Biomarkers Derived from Key Processes of Cancerogenesis},
   year = {2016}
}

TY  - CHAP
ID  - 1370920
AU  - Raudenská, Martina - Gumulec, Jaromír - Fribley, Andrew M. - Masařík, Michal
PY  - 2016
TI  - HNSCC Biomarkers Derived from Key Processes of Cancerogenesis
VL  - Neuveden
PB  - Springer International Publishing
CY  - Switzerland
SN  - 9783319276472
KW  - Head and neck squamous cell carcinoma
N2  - Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent aggressive cancers in humans. Well-known risk factors include HPV infection, tobacco smoking, and alcohol consumption. HNSCC overall survival rate is one of the lowest among human malignancies. The poor prognosis of HNSCC often results from late-stage diagnosis, therapeutic resistance, high rates of recurrence, and frequent metastases to lymph nodes. To date, the TNM classification is still the best evaluation of disease progress; however, this method of staging does not pay attention to the molecular basis of tumorigenesis. An improvement in treatment efficacy and diagnostic capabilities will be realized through a better understanding of the pathogenesis and characteristics of HNSCC, a disease that has come to be characterized by confounding heterogeneity. This chapter is focused on molecular markers derived from key processes of cancero-genesis that are involved in metastasis, treatment resistance, avoidance of immune detection, inflammation, induction of angiogenesis, genome instability, dysregulation of cellular energetics, cell death, cancer stem cell biology, and rearrangement of tissues adjacent to the tumor. We will discuss biomarkers identified at different levels of cellular regulation (DNA, RNA, miRNA, and protein markers).
ER  -

RAUDENSKÁ, Martina; Jaromír GUMULEC; Andrew M. FRIBLEY and Michal MASAŘÍK. HNSCC Biomarkers Derived from Key Processes of Cancerogenesis. Online. In Andrew M. Fribley. \textit{Targeting Oral Cancer}. Switzerland: Springer International Publishing, 2016, p.~115-160. ISBN~978-3-319-27647-2.

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