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@article{1370927,
author = {Bednařík, Petr and Tkáč, Ivan and Giove, Federico and Eberly, Lynn and Deelchand, Dinesh and Barreto, Felipe and Mangia, Silvia},
article_number = {2},
doi = {http://dx.doi.org/10.1177/0271678X17695291},
keywords = {MR spectroscopy; lactate; glutamate; energy metabolism; functional MRI},
language = {eng},
issn = {0271-678X},
journal = {Journal of Cerebral Blood Flow and Metabolism},
title = {Neurochemical Responses to Chromatic and Achromatic Stimuli in the Human Visual Cortex},
url = {http://journals.sagepub.com/doi/abs/10.1177/0271678X17695291?journalCode=jcba},
volume = {38},
year = {2018}
}
TY - JOUR
ID - 1370927
AU - Bednařík, Petr - Tkáč, Ivan - Giove, Federico - Eberly, Lynn - Deelchand, Dinesh - Barreto, Felipe - Mangia, Silvia
PY - 2018
TI - Neurochemical Responses to Chromatic and Achromatic Stimuli in the Human Visual Cortex
JF - Journal of Cerebral Blood Flow and Metabolism
VL - 38
IS - 2
SP - 347-359
EP - 347-359
SN - 0271678X
KW - MR spectroscopy
KW - lactate
KW - glutamate
KW - energy metabolism
KW - functional MRI
UR - http://journals.sagepub.com/doi/abs/10.1177/0271678X17695291?journalCode=jcba
L2 - http://journals.sagepub.com/doi/abs/10.1177/0271678X17695291?journalCode=jcba
N2 - In the present study we aimed at determining the metabolic responses of the human visual cortex during the presentation of chromatic and achromatic stimuli, known to preferentially activate two separate clusters of neuronal populations (called “blobs” and “interblobs”) with distinct sensitivity to color or luminance features. Since blobs and interblobs have different cytochrome-oxidase (COX) content and micro-vascularization level (i.e., different capacities for glucose oxidation), different functional metabolic responses during chromatic vs. achromatic stimuli may be expected. The stimuli were optimized to evoke a similar load of neuronal activation as measured by the bold oxygenation level dependent (BOLD) contrast. Metabolic responses were assessed using functional 1H MRS at 7 T in 12 subjects. During both chromatic and achromatic stimuli, we observed the typical increases in glutamate and lactate concentration, and decreases in aspartate and glucose concentration, that are indicative of increased glucose oxidation. However, within the detection sensitivity limits we did not observe any difference between metabolic responses elicited by chromatic and achromatic stimuli. We conclude that the higher energy demands of activated blobs and interblobs are supported by similar increases in oxidative metabolism despite the different capacities of these neuronal populations.
ER -
BEDNAŘÍK, Petr, Ivan TKÁČ, Federico GIOVE, Lynn EBERLY, Dinesh DEELCHAND, Felipe BARRETO a Silvia MANGIA. Neurochemical Responses to Chromatic and Achromatic Stimuli in the Human Visual Cortex. \textit{Journal of Cerebral Blood Flow and Metabolism}. 2018, roč.~38, č.~2, s.~347-359. ISSN~0271-678X. Dostupné z: https://dx.doi.org/10.1177/0271678X17695291.
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