J 2017

Precipitating factors and 90-day outcome of acute heart failure: A report from the intercontinental GREAT registry

ARRIGO, Mattia, Etienne GAYAT, Jiří PAŘENICA, Shiro ISHIHARA, Jian ZHANG et. al.

Základní údaje

Originální název

Precipitating factors and 90-day outcome of acute heart failure: A report from the intercontinental GREAT registry

Autoři

ARRIGO, Mattia (250 Francie), Etienne GAYAT (250 Francie), Jiří PAŘENICA (203 Česká republika, garant, domácí), Shiro ISHIHARA (392 Japonsko), Jian ZHANG (156 Čína), Dong-Ju CHOI (410 Korejská republika), Jin Joo PARK (410 Korejská republika), Khalid F. ALHABIB (682 Saúdská Arábie), Naoki SATO (392 Japonsko), Oscar MIRO (724 Španělsko), Aldo P. MAGGIONI (380 Itálie), Yuhui ZHANG (156 Čína), Jindřich ŠPINAR (203 Česká republika, domácí), Alain COHEN-SOLAL (250 Francie), Theodore J. IWASHYNA (840 Spojené státy) a Alexandre MEBAZAA (250 Francie)

Vydání

European Journal of Heart Failure, Hoboken, Oxford University Press, 2017, 1388-9842

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 10.683

Kód RIV

RIV/00216224:14110/17:00096104

Organizační jednotka

Lékařská fakulta

UT WoS

000393944500005

Klíčová slova anglicky

Acute coronary syndrome; Acute heart failure; Atrial fibrillation; Mortality; Outcome; Precipitating factor

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 21. 3. 2018 16:38, Soňa Böhmová

Anotace

V originále

Aims: Several clinical conditions may precipitate acute heart failure (AHF) and influence clinical outcome. In this study we hypothesized that precipitating factors are independently associated with 90-day risk of death in AHF. Methods and results: The study population consisted of 15 828 AHF patients from Europe and Asia. The primary outcome was 90-day all-cause mortality according to identified precipitating factors of AHF [acute coronary syndrome (ACS), infection, atrial fibrillation (AF), hypertension, and non-compliance]. Mortality at 90 days was 15.8%. AHF precipitated by ACS or by infection showed increased 90-day risk of death compared with AHF without identified precipitants [hazard ratio (HR) 1.69, 95% confidence interval (CI) 1.44-1.97, P < 0.001; and HR 1.51, 95% CI 1.18-1.92, P = 0.001), while AHF precipitated by AF showed lower 90-day risk of death (HR 0.56, 95% CI 0.42-0.75, P < 0.001), after multivariable adjustment. The risk of death in AHF precipitated by ACS was the highest during the first week after admission, while in AHF precipitated by infection the risk of death had a delayed peak at week 3. In AHF precipitated by AF, a trend toward reduced risk of death during the first weeks was shown. At weeks 5-6, AHF precipitated by ACS, infection, or AF showed similar risk of death to that of AHF without identified precipitants. Conclusions: Precipitating factors are independently associated with 90-day mortality in AHF. AHF precipitated by ACS or infection is independently associated with higher, while AHF precipitated by AF is associated with lower 90-day risk of death.