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@article{1371159,
author = {Arrigo, Mattia and Gayat, Etienne and Pařenica, Jiří and Ishihara, Shiro and Zhang, Jian and Choi, DongandJu and Park, Jin Joo and Alhabib, Khalid F. and Sato, Naoki and Miro, Oscar and Maggioni, Aldo P. and Zhang, Yuhui and Špinar, Jindřich and CohenandSolal, Alain and Iwashyna, Theodore J. and Mebazaa, Alexandre},
article_location = {Hoboken},
article_number = {2},
doi = {http://dx.doi.org/10.1002/ejhf.682},
keywords = {Acute coronary syndrome; Acute heart failure; Atrial fibrillation; Mortality; Outcome; Precipitating factor},
language = {eng},
issn = {1388-9842},
journal = {European Journal of Heart Failure},
title = {Precipitating factors and 90-day outcome of acute heart failure: A report from the intercontinental GREAT registry},
volume = {19},
year = {2017}
}
TY - JOUR
ID - 1371159
AU - Arrigo, Mattia - Gayat, Etienne - Pařenica, Jiří - Ishihara, Shiro - Zhang, Jian - Choi, Dong-Ju - Park, Jin Joo - Alhabib, Khalid F. - Sato, Naoki - Miro, Oscar - Maggioni, Aldo P. - Zhang, Yuhui - Špinar, Jindřich - Cohen-Solal, Alain - Iwashyna, Theodore J. - Mebazaa, Alexandre
PY - 2017
TI - Precipitating factors and 90-day outcome of acute heart failure: A report from the intercontinental GREAT registry
JF - European Journal of Heart Failure
VL - 19
IS - 2
SP - 201-208
EP - 201-208
PB - Oxford University Press
SN - 13889842
KW - Acute coronary syndrome
KW - Acute heart failure
KW - Atrial fibrillation
KW - Mortality
KW - Outcome
KW - Precipitating factor
N2 - Aims: Several clinical conditions may precipitate acute heart failure (AHF) and influence clinical outcome. In this study we hypothesized that precipitating factors are independently associated with 90-day risk of death in AHF. Methods and results: The study population consisted of 15 828 AHF patients from Europe and Asia. The primary outcome was 90-day all-cause mortality according to identified precipitating factors of AHF [acute coronary syndrome (ACS), infection, atrial fibrillation (AF), hypertension, and non-compliance]. Mortality at 90 days was 15.8%. AHF precipitated by ACS or by infection showed increased 90-day risk of death compared with AHF without identified precipitants [hazard ratio (HR) 1.69, 95% confidence interval (CI) 1.44-1.97, P < 0.001; and HR 1.51, 95% CI 1.18-1.92, P = 0.001), while AHF precipitated by AF showed lower 90-day risk of death (HR 0.56, 95% CI 0.42-0.75, P < 0.001), after multivariable adjustment. The risk of death in AHF precipitated by ACS was the highest during the first week after admission, while in AHF precipitated by infection the risk of death had a delayed peak at week 3. In AHF precipitated by AF, a trend toward reduced risk of death during the first weeks was shown. At weeks 5-6, AHF precipitated by ACS, infection, or AF showed similar risk of death to that of AHF without identified precipitants. Conclusions: Precipitating factors are independently associated with 90-day mortality in AHF. AHF precipitated by ACS or infection is independently associated with higher, while AHF precipitated by AF is associated with lower 90-day risk of death.
ER -
ARRIGO, Mattia, Etienne GAYAT, Jiří PAŘENICA, Shiro ISHIHARA, Jian ZHANG, Dong-Ju CHOI, Jin Joo PARK, Khalid F. ALHABIB, Naoki SATO, Oscar MIRO, Aldo P. MAGGIONI, Yuhui ZHANG, Jindřich ŠPINAR, Alain COHEN-SOLAL, Theodore J. IWASHYNA and Alexandre MEBAZAA. Precipitating factors and 90-day outcome of acute heart failure: A report from the intercontinental GREAT registry. \textit{European Journal of Heart Failure}. Hoboken: Oxford University Press, 2017, vol.~19, No~2, p.~201-208. ISSN~1388-9842. Available from: https://dx.doi.org/10.1002/ejhf.682.
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