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@article{1371983,
author = {Konig, Maria and Escher, Beate I. and Neale, Peta A. and Krauss, Martin and Hilscherová, Klára and Novák, Jiří and Teodorovic, Ivana and Schulze, Tobias and Seidensticker, Sven and Hashmi, Muhammad Arslan Kamal and Ahlheim, Joerg and Brack, Werner},
article_location = {OXFORD},
article_number = {January},
doi = {http://dx.doi.org/10.1016/j.envpol.2016.11.011},
keywords = {Bioassay; Xenobiotic metabolism; Specific modes of action; Adaptive stress response; Bioanalytical equivalent concentration},
language = {eng},
issn = {0269-7491},
journal = {Environmental Pollution},
title = {Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis},
url = {http://www.sciencedirect.com/science/article/pii/S0269749116307758},
volume = {220},
year = {2017}
}
TY - JOUR
ID - 1371983
AU - Konig, Maria - Escher, Beate I. - Neale, Peta A. - Krauss, Martin - Hilscherová, Klára - Novák, Jiří - Teodorovic, Ivana - Schulze, Tobias - Seidensticker, Sven - Hashmi, Muhammad Arslan Kamal - Ahlheim, Joerg - Brack, Werner
PY - 2017
TI - Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis
JF - Environmental Pollution
VL - 220
IS - January
SP - 1220-1230
EP - 1220-1230
PB - ELSEVIER SCI LTD
SN - 02697491
KW - Bioassay
KW - Xenobiotic metabolism
KW - Specific modes of action
KW - Adaptive stress response
KW - Bioanalytical equivalent concentration
UR - http://www.sciencedirect.com/science/article/pii/S0269749116307758
L2 - http://www.sciencedirect.com/science/article/pii/S0269749116307758
N2 - Complex mixtures of micropollutants, including pesticides, pharmaceuticals and industrial chemicals emitted by wastewater effluents to European rivers may compromise the quality of these water resources and may pose a risk to ecosystem health and abstraction of drinking water. In the present study, an integrated analytical and bioanalytical approach was applied to investigate the impact of untreated wastewater effluents from the city of Novi Sad, Serbia, into the River Danube. The study was based on three on-site large volume solid phase extracted water samples collected upstream and downstream of the untreated wastewater discharge. Chemical screening with liquid chromatography high resolution mass spectrometry (LC-HRMS) was applied together with a battery of in vitro cell-based bioassays covering important steps of the cellular toxicity pathway to evaluate effects on the activation of metabolism (arylhydrocarbon receptor AhR, peroxisome proliferator activated receptor gamma PPAR gamma), specific modes of action (estrogen receptor ER alpha, androgen receptor AR) and adaptive stress responses (oxidative stress, inflammation). Increased effects, significantly changed contamination patterns and higher chemical concentrations were observed downstream of the wastewater discharge. A mass balance approach showed that enhanced endocrine disruption was in good agreement with concentrations of detected hormones, while only a smaller fraction of the effects on xenobiotic metabolism (<1%) and adaptive stress responses (0-12%) could be explained by the detected chemicals. The chemical and effects patterns observed upstream of the discharge point were fairly re-established at about 7 km downstream, demonstrating the enormous dilution capacity of this large river.
ER -
KONIG, Maria, Beate I. ESCHER, Peta A. NEALE, Martin KRAUSS, Klára HILSCHEROVÁ, Jiří NOVÁK, Ivana TEODOROVIC, Tobias SCHULZE, Sven SEIDENSTICKER, Muhammad Arslan Kamal HASHMI, Joerg AHLHEIM and Werner BRACK. Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis. \textit{Environmental Pollution}. OXFORD: ELSEVIER SCI LTD, vol.~220, January, p.~1220-1230. ISSN~0269-7491. doi:10.1016/j.envpol.2016.11.011. 2017.
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