Teratogenic effects of five anticancer drugs on Xenopus laevis
embryo

J 2016

Teratogenic effects of five anticancer drugs on Xenopus laevis embryo

ISIDORI, Marina, Concetta PISCITELLI, Chiara RUSSO, Marie SMUTNÁ, Luděk BLÁHA et. al.

Základní údaje

Originální název

Teratogenic effects of five anticancer drugs on Xenopus laevis embryo

Autoři

ISIDORI, Marina (380 Itálie), Concetta PISCITELLI (380 Itálie), Chiara RUSSO (380 Itálie), Marie SMUTNÁ (203 Česká republika, domácí) a Luděk BLÁHA (203 Česká republika, garant, domácí)

Vydání

Ecotoxicology and Environmental Safety, San Diego (CA) USA, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2016, 0147-6513

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.743

Kód RIV

RIV/00216224:14310/16:00093518

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.ecoenv.2016.06.044

UT WoS

000384398800011

Klíčová slova anglicky

Anticancer drugs; FETAX; Teratogenicity; Xenopus laevis

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 4. 2017 11:52, Ing. Andrea Mikešková

Anotace

V originále

In recent years, the environmental presence of pharmaceuticals - including anticancer drugs - is an emerging issue. Because of the lack of appropriate critical studies about anticancer drug effects in frogs, the aim of the present study was to investigate lethal and teratogenic effects of five anticancer drugs widely used in large quantities, i.e. 5-flourouracil, capecitabine, cisplatin, etoposide, and imatinib, in the embryos of the South African clawed frog, Xenopus laevis, using FETAX - Frog Embryo Teratogenesis Assay in Xenopus. None of the studied anticancer drugs induced statistically significant mortality within the concentrations tested (0.01-50mg/L, depending on the studied compound), and no growth inhibition of embryos after a 96-h exposure was observed. Except for cisplatin, the other pharmaceuticals induced an increase of developmental malformations such as abdominal edema, axial flexure, head, eyes, gut and heart malformations with statistically significant effects observed at the highest concentrations tested (50 mg/L for 5-flourouracil; 30 mg/L for etoposide and 20 mg/L for capecitabine and imatinib). The results indicate that anticancer drugs can affect embryogenesis mechanisms.

Návaznosti

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

LO1214, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Centrum pro výzkum toxických látek v prostředí

Citovat

ISIDORI, Marina, Concetta PISCITELLI, Chiara RUSSO, Marie SMUTNÁ a Luděk BLÁHA. Teratogenic effects of five anticancer drugs on Xenopus laevis embryo. Ecotoxicology and Environmental Safety. San Diego (CA) USA: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2016, roč. 133, November, s. 90-96. ISSN 0147-6513. Dostupné z: https://dx.doi.org/10.1016/j.ecoenv.2016.06.044.

@article{1372447,
   author = {Isidori, Marina and Piscitelli, Concetta and Russo, Chiara and Smutná, Marie and Bláha, Luděk},
   article_location = {San Diego (CA) USA},
   article_number = {November},
   doi = {http://dx.doi.org/10.1016/j.ecoenv.2016.06.044},
   keywords = {Anticancer drugs; FETAX; Teratogenicity; Xenopus laevis},
   language = {eng},
   issn = {0147-6513},
   journal = {Ecotoxicology and Environmental Safety},
   title = {Teratogenic effects of five anticancer drugs on Xenopus laevis embryo},
   url = {http://www.sciencedirect.com/science/article/pii/S0147651316302500},
   volume = {133},
   year = {2016}
}

TY  - JOUR
ID  - 1372447
AU  - Isidori, Marina - Piscitelli, Concetta - Russo, Chiara - Smutná, Marie - Bláha, Luděk
PY  - 2016
TI  - Teratogenic effects of five anticancer drugs on Xenopus laevis embryo
JF  - Ecotoxicology and Environmental Safety
VL  - 133
IS  - November
SP  - 90-96
EP  - 90-96
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 01476513
KW  - Anticancer drugs
KW  - FETAX
KW  - Teratogenicity
KW  - Xenopus laevis
UR  - http://www.sciencedirect.com/science/article/pii/S0147651316302500
L2  - http://www.sciencedirect.com/science/article/pii/S0147651316302500
N2  - In recent years, the environmental presence of pharmaceuticals - including anticancer drugs - is an emerging issue. Because of the lack of appropriate critical studies about anticancer drug effects in frogs, the aim of the present study was to investigate lethal and teratogenic effects of five anticancer drugs widely used in large quantities, i.e. 5-flourouracil, capecitabine, cisplatin, etoposide, and imatinib, in the embryos of the South African clawed frog, Xenopus laevis, using FETAX - Frog Embryo Teratogenesis Assay in Xenopus. None of the studied anticancer drugs induced statistically significant mortality within the concentrations tested (0.01-50mg/L, depending on the studied compound), and no growth inhibition of embryos after a 96-h exposure was observed. Except for cisplatin, the other pharmaceuticals induced an increase of developmental malformations such as abdominal edema, axial flexure, head, eyes, gut and heart malformations with statistically significant effects observed at the highest concentrations tested (50 mg/L for 5-flourouracil; 30 mg/L for etoposide and 20 mg/L for capecitabine and imatinib). The results indicate that anticancer drugs can affect embryogenesis mechanisms.
ER  -

ISIDORI, Marina, Concetta PISCITELLI, Chiara RUSSO, Marie SMUTNÁ a Luděk BLÁHA. Teratogenic effects of five anticancer drugs on Xenopus laevis embryo. \textit{Ecotoxicology and Environmental Safety}. San Diego (CA) USA: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2016, roč.~133, November, s.~90-96. ISSN~0147-6513. Dostupné z: https://dx.doi.org/10.1016/j.ecoenv.2016.06.044.

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