Chemopreventive Agents Attenuate Rapid Inhibition of Gap
Junctional Intercellular Communication Induced by Environmental
Toxicants

J 2016

Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants

BABICA, Pavel, Lucie ČTVERÁČKOVÁ, Zuzana LENČEŠOVÁ, James E. TROSKO, Brad L. UPHAM et. al.

Základní údaje

Originální název

Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants

Autoři

BABICA, Pavel (203 Česká republika, garant, domácí), Lucie ČTVERÁČKOVÁ (203 Česká republika, domácí), Zuzana LENČEŠOVÁ (203 Česká republika, domácí), James E. TROSKO (840 Spojené státy) a Brad L. UPHAM (840 Spojené státy)

Vydání

Nutrition and cancer : an international journal, ABINGDON, ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2016, 0163-5581

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.447

Kód RIV

RIV/00216224:14310/16:00093527

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1080/01635581.2016.1180409

UT WoS

000380883200013

Klíčová slova anglicky

CELL-CELL COMMUNICATION; CANCER CHEMOPREVENTION; STEM-CELLS; GREEN TEA; H2O2-INDUCED INHIBITION; CHEMICAL CARCINOGENESIS; DOWN-REGULATION; CHEMOTHERAPY; PREVENTION; QUERCETIN

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 3. 2017 12:12, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Altered gap junctional intercellular communication (GJIC) has been associated with chemical carcinogenesis, where both chemical tumor promoters and chemopreventive agents (CPAs) are known to conversely modulate GJIC. The aim of this study was to investigate whether attenuation of chemically inhibited GJIC represents a common outcome induced by different CPAs, which could be effectively evaluated using in vitro methods. Rat liver epithelial cells WB-F344 were pretreated with a CPA for either 30min or 24h, and then exposed to GJIC-inhibiting concentration of a selected tumor promoter or environmental toxicant [12-O-tetradecanoylphorbol-13-acetate (TPA), lindane, fluoranthene, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT), perfluorooctanoic acid (PFOA), or pentachlorophenol]. Out of nine CPAs tested, quercetin and silibinin elicited the most pronounced effects, preventing the dysregulation of GJIC by all the GJIC inhibitors, but DDT. Metformin and curcumin attenuated the effects of three GJIC inhibitors, whereas the other CPAs prevented the effects of two (diallyl sulfide, emodin) or one (indole-3-carbinol, thymoquinone) GJIC inhibitor. Significant attenuation of chemically induced inhibition of GJIC was observed in 27 (50%) out of 54 possible combinations of nine CPAs and six GJIC inhibitors. Our data demonstrate that in vitro evaluation of GJIC can be used as an effective screening tool for identification of chemicals with potential chemopreventive activity.

Návaznosti

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

LO1214, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Centrum pro výzkum toxických látek v prostředí

Citovat

BABICA, Pavel, Lucie ČTVERÁČKOVÁ, Zuzana LENČEŠOVÁ, James E. TROSKO a Brad L. UPHAM. Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants. Nutrition and cancer : an international journal. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2016, roč. 68, č. 5, s. 827-837. ISSN 0163-5581. Dostupné z: https://dx.doi.org/10.1080/01635581.2016.1180409.

@article{1372466,
   author = {Babica, Pavel and Čtveráčková, Lucie and Lenčešová, Zuzana and Trosko, James E. and Upham, Brad L.},
   article_location = {ABINGDON},
   article_number = {5},
   doi = {http://dx.doi.org/10.1080/01635581.2016.1180409},
   keywords = {CELL-CELL COMMUNICATION; CANCER CHEMOPREVENTION; STEM-CELLS; GREEN TEA; H2O2-INDUCED INHIBITION; CHEMICAL CARCINOGENESIS; DOWN-REGULATION; CHEMOTHERAPY; PREVENTION; QUERCETIN},
   language = {eng},
   issn = {0163-5581},
   journal = {Nutrition and cancer : an international journal},
   title = {Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants},
   url = {http://www.tandfonline.com/doi/abs/10.1080/01635581.2016.1180409?journalCode=hnuc20},
   volume = {68},
   year = {2016}
}

TY  - JOUR
ID  - 1372466
AU  - Babica, Pavel - Čtveráčková, Lucie - Lenčešová, Zuzana - Trosko, James E. - Upham, Brad L.
PY  - 2016
TI  - Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants
JF  - Nutrition and cancer : an international journal
VL  - 68
IS  - 5
SP  - 827-837
EP  - 827-837
PB  - ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
SN  - 01635581
KW  - CELL-CELL COMMUNICATION
KW  - CANCER CHEMOPREVENTION
KW  - STEM-CELLS
KW  - GREEN TEA
KW  - H2O2-INDUCED INHIBITION
KW  - CHEMICAL CARCINOGENESIS
KW  - DOWN-REGULATION
KW  - CHEMOTHERAPY
KW  - PREVENTION
KW  - QUERCETIN
UR  - http://www.tandfonline.com/doi/abs/10.1080/01635581.2016.1180409?journalCode=hnuc20
L2  - http://www.tandfonline.com/doi/abs/10.1080/01635581.2016.1180409?journalCode=hnuc20
N2  - Altered gap junctional intercellular communication (GJIC) has been associated with chemical carcinogenesis, where both chemical tumor promoters and chemopreventive agents (CPAs) are known to conversely modulate GJIC. The aim of this study was to investigate whether attenuation of chemically inhibited GJIC represents a common outcome induced by different CPAs, which could be effectively evaluated using in vitro methods. Rat liver epithelial cells WB-F344 were pretreated with a CPA for either 30min or 24h, and then exposed to GJIC-inhibiting concentration of a selected tumor promoter or environmental toxicant [12-O-tetradecanoylphorbol-13-acetate (TPA), lindane, fluoranthene, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT), perfluorooctanoic acid (PFOA), or pentachlorophenol]. Out of nine CPAs tested, quercetin and silibinin elicited the most pronounced effects, preventing the dysregulation of GJIC by all the GJIC inhibitors, but DDT. Metformin and curcumin attenuated the effects of three GJIC inhibitors, whereas the other CPAs prevented the effects of two (diallyl sulfide, emodin) or one (indole-3-carbinol, thymoquinone) GJIC inhibitor. Significant attenuation of chemically induced inhibition of GJIC was observed in 27 (50%) out of 54 possible combinations of nine CPAs and six GJIC inhibitors. Our data demonstrate that in vitro evaluation of GJIC can be used as an effective screening tool for identification of chemicals with potential chemopreventive activity.
ER  -

BABICA, Pavel, Lucie ČTVERÁČKOVÁ, Zuzana LENČEŠOVÁ, James E. TROSKO a Brad L. UPHAM. Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants. \textit{Nutrition and cancer : an international journal}. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR \&{}amp; FRANCIS LTD, 2016, roč.~68, č.~5, s.~827-837. ISSN~0163-5581. Dostupné z: https://dx.doi.org/10.1080/01635581.2016.1180409.

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