| SANTOS, R., S. GIDDING, R. HEGELE, M. CUCHEL, P. BARTER, G. WATTS, S. BAUM, A. CATAPANO, MJ. CHAPMAN, J. DEFESCHE, F. FOLCO, Tomáš FREIBERGER, J. GENEST, GK. HOVINGH, M. HARADA-SHIBA, S. HUMPHRIES, A. JACKSON, P. MATA, P. MORIARTY, F. RAAL, K. AL-RASADI, K. RAY, Z. REINER, E. SIJBRANDS a S. YAMASHITA. Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel. Lancet Diabetes & Endocrinology. New York: ELSEVIER SCIENCE INC, 2016, roč. 4, č. 10, s. 850-861. ISSN 2213-8587. Dostupné z: https://dx.doi.org/10.1016/S2213-8587(16)30041-9. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1372876,
author = {Santos, R. and Gidding, S. and Hegele, R. and Cuchel, M. and Barter, P. and Watts, G. and Baum, S. and Catapano, A. and Chapman, MJ. and Defesche, J. and Folco, F. and Freiberger, Tomáš and Genest, J. and Hovingh, GK. and HaradaandShiba, M. and Humphries, S. and Jackson, A. and Mata, P. and Moriarty, P. and Raal, F. and AlandRasadi, K. and Ray, K. and Reiner, Z. and Sijbrands, E. and Yamashita, S.},
article_location = {New York},
article_number = {10},
doi = {http://dx.doi.org/10.1016/S2213-8587(16)30041-9},
keywords = {familial hypercholesterolaemia; clinical management; consensus statement},
language = {eng},
issn = {2213-8587},
journal = {Lancet Diabetes & Endocrinology},
title = {Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel},
url = {https://is.muni.cz/auth/publikace/vyber_publikaci},
volume = {4},
year = {2016}
}
TY - JOUR
ID - 1372876
AU - Santos, R. - Gidding, S. - Hegele, R. - Cuchel, M. - Barter, P. - Watts, G. - Baum, S. - Catapano, A. - Chapman, MJ. - Defesche, J. - Folco, F. - Freiberger, Tomáš - Genest, J. - Hovingh, GK. - Harada-Shiba, M. - Humphries, S. - Jackson, A. - Mata, P. - Moriarty, P. - Raal, F. - Al-Rasadi, K. - Ray, K. - Reiner, Z. - Sijbrands, E. - Yamashita, S.
PY - 2016
TI - Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel
JF - Lancet Diabetes & Endocrinology
VL - 4
IS - 10
SP - 850-861
EP - 850-861
PB - ELSEVIER SCIENCE INC
SN - 22138587
KW - familial hypercholesterolaemia
KW - clinical management
KW - consensus statement
UR - https://is.muni.cz/auth/publikace/vyber_publikaci
L2 - https://is.muni.cz/auth/publikace/vyber_publikaci
N2 - Familial hypercholesterolaemia is common in individuals who had a myocardial infarction at a young age. As many as one in 200 people could have heterozygous familial hypercholesterolaemia, and up to one in 300 000 individuals could be homozygous. The phenotypes of heterozygous and homozygous familial hypercholesterolaemia overlap considerably; the response to treatment is also heterogeneous. In this Review, we aim to define a phenotype for severe familial hypercholesterolaemia and identify people at highest risk for cardiovascular disease, based on the concentration of LDL cholesterol in blood and individuals' responsiveness to conventional lipid-lowering treatment. We assess the importance of molecular characterisation and define the role of other cardiovascular risk factors and advanced subclinical coronary atherosclerosis in risk stratification. Individuals with severe familial hypercholesterolaemia might benefit in particular from early and more aggressive cholesterol-lowering treatment (eg, with PCSK9 inhibitors). In addition to better tailored therapy, more precise characterisation of individuals with severe familial hypercholesterolaemia could improve resource use.
ER -
SANTOS, R., S. GIDDING, R. HEGELE, M. CUCHEL, P. BARTER, G. WATTS, S. BAUM, A. CATAPANO, MJ. CHAPMAN, J. DEFESCHE, F. FOLCO, Tomáš FREIBERGER, J. GENEST, GK. HOVINGH, M. HARADA-SHIBA, S. HUMPHRIES, A. JACKSON, P. MATA, P. MORIARTY, F. RAAL, K. AL-RASADI, K. RAY, Z. REINER, E. SIJBRANDS a S. YAMASHITA. Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel. \textit{Lancet Diabetes \&{} Endocrinology}. New York: ELSEVIER SCIENCE INC, 2016, roč.~4, č.~10, s.~850-861. ISSN~2213-8587. Dostupné z: https://dx.doi.org/10.1016/S2213-8587(16)30041-9.
|
