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@article{1373371,
author = {Michlovska, L. and Vojtova, L. and Humpa, Otakar and Kucerik, J. and Zidek, J. and Jancar, J.},
article_location = {Cambridge},
article_number = {20},
doi = {http://dx.doi.org/10.1039/c5ra26222d},
keywords = {ITACONIC ANHYDRIDE; COPOLYMERS; METHACRYLATE; COMPOSITES; OLIGOMERS; POLYMERS; DELIVERY; LACTIDE},
language = {eng},
issn = {2046-2069},
journal = {RSC Advances},
title = {Hydrolytic stability of end-linked hydrogels from PLGA-PEG-PLGA macromonomers terminated by alpha,omega-itaconyl groups},
url = {http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA26222D#!divAbstract},
volume = {6},
year = {2016}
}
TY - JOUR
ID - 1373371
AU - Michlovska, L. - Vojtova, L. - Humpa, Otakar - Kucerik, J. - Zidek, J. - Jancar, J.
PY - 2016
TI - Hydrolytic stability of end-linked hydrogels from PLGA-PEG-PLGA macromonomers terminated by alpha,omega-itaconyl groups
JF - RSC Advances
VL - 6
IS - 20
SP - 16808-16816
EP - 16808-16816
PB - Royal Society of Chemistry
SN - 20462069
KW - ITACONIC ANHYDRIDE
KW - COPOLYMERS
KW - METHACRYLATE
KW - COMPOSITES
KW - OLIGOMERS
KW - POLYMERS
KW - DELIVERY
KW - LACTIDE
UR - http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA26222D#!divAbstract
L2 - http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA26222D#!divAbstract
N2 - Biodegradable amphiphilic PLGA-PEG-PLGA triblock copolymers end-terminated with itaconic acid (ITA) having reactive double bonds were synthesized by ring opening polymerization. The prepared alpha,omega-itaconyl-PLGA- PEG-PLGA telechelic macromonomers were additionally covalently crosslinked under an inert atmosphere by blue light irradiation without the use of a further cross-linker resulting in end-linked polymeric networks. The effects of the ITA amount attached to the alpha,omega-itaconyl-PLGA-PEG-PLGA copolymers and the crosslinking time on swelling behaviours and hydrolytic stability of the prepared well-defined polymeric network were investigated. Physicochemical properties were characterized by proton and carbon nuclear magnetic resonance spectroscopy (H-1 NMR, C-13 NMR), proton nuclear magnetic resonance relaxometry, attenuated total reflectance Fourier transformed infrared spectroscopy (ATR-FTIR) and thermogravimetric analysis (TGA). It was found that the hydrolytic stability of ITA modified PLGA-PEG-PLGA end-linked hydrogels enhances with both increasing the time of crosslinking and the amount of double bonds attached to alpha,omega-itaconyl-PLGA-PEG-PLGA polymer chains. In comparison with the original un-crosslinked alpha,omega-itaconyl-PLGA-PEG-PLGA copolymer, the hydrolytic stability of the end-linked hydrogels significantly increased. Three kinds of water fractions (unbound, weakly and strongly bonded) were determined by proton NMR relaxometry in hydrogels containing 63 mol% of ITA crosslinked for 40 minutes. Even for hydrogels surviving 32 days in water the NMR relaxometry showed structural collapse of the hydrogel probably due to breaking of end-linked nodes followed by hydrolysis faster than water diffusion after day 15 of immersion. End-linked alpha,omega-itaconyl-PLGA- PEG-PLGA hydrogels can be used in medical, biological or tissue engineering applications.
ER -
MICHLOVSKA, L., L. VOJTOVA, Otakar HUMPA, J. KUCERIK, J. ZIDEK a J. JANCAR. Hydrolytic stability of end-linked hydrogels from PLGA-PEG-PLGA macromonomers terminated by alpha,omega-itaconyl groups. \textit{RSC Advances}. Cambridge: Royal Society of Chemistry, 2016, roč.~6, č.~20, s.~16808-16816. ISSN~2046-2069. Dostupné z: https://dx.doi.org/10.1039/c5ra26222d.
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