| TÝČOVÁ, Anna, Marek VIDO, Petra KOVARIKOVA and František FORET. Interface-free capillary electrophoresis-mass spectrometry system with nanospray ionization Analysis of dexrazoxane in blood plasma. Journal of Chromatography A. Amsterdam: ELSEVIER SCIENCE BV, 2016, vol. 1466, SEP, p. 173-179. ISSN 0021-9673. Available from: https://dx.doi.org/10.1016/j.chroma.2016.08.042. |
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@article{1374169,
author = {Týčová, Anna and Vido, Marek and Kovarikova, Petra and Foret, František},
article_location = {Amsterdam},
article_number = {SEP},
doi = {http://dx.doi.org/10.1016/j.chroma.2016.08.042},
keywords = {Capillary electrophoresis; Mass spectrometry; Nanospray; Hydrophobic coating; Interface Dexrazoxane},
language = {eng},
issn = {0021-9673},
journal = {Journal of Chromatography A},
title = {Interface-free capillary electrophoresis-mass spectrometry system with nanospray ionization Analysis of dexrazoxane in blood plasma},
url = {http://www.sciencedirect.com/science/article/pii/S0021967316311190},
volume = {1466},
year = {2016}
}
TY - JOUR
ID - 1374169
AU - Týčová, Anna - Vido, Marek - Kovarikova, Petra - Foret, František
PY - 2016
TI - Interface-free capillary electrophoresis-mass spectrometry system with nanospray ionization Analysis of dexrazoxane in blood plasma
JF - Journal of Chromatography A
VL - 1466
IS - SEP
SP - 173-179
EP - 173-179
PB - ELSEVIER SCIENCE BV
SN - 00219673
KW - Capillary electrophoresis
KW - Mass spectrometry
KW - Nanospray
KW - Hydrophobic coating
KW - Interface Dexrazoxane
UR - http://www.sciencedirect.com/science/article/pii/S0021967316311190
L2 - http://www.sciencedirect.com/science/article/pii/S0021967316311190
N2 - The newly developed interface-free capillary electrophoresis-nanospray/mass spectrometry system (CE-nESI/MS) was applied for rapid analysis of the cardioprotective drug dexrazoxane and its hydrolysed form ADR-925 in deproteinized blood plasma samples. The aim of this study was to test the simplest possible CE-nESI/MS instrumentation for analyses of real samples. This interface-free system, utilizing single piece of a narrow bore capillary as both the electrophoretic separation column and the nanospray emitter, was operated at a flow rate of 30 nL/min. Excellent electrophoretic separation and sensitive nanospray ionization was achieved with the use of only one high voltage power supply. In addition, hydrophobic external coating was developed and tested for additional stability of the nanospray ionization. To our knowledge this is the first study devoted to the analysis of dexrazoxane and ADR-925 by capillary electrophoresis-mass spectrometry.
ER -
TÝČOVÁ, Anna, Marek VIDO, Petra KOVARIKOVA and František FORET. Interface-free capillary electrophoresis-mass spectrometry system with nanospray ionization Analysis of dexrazoxane in blood plasma. \textit{Journal of Chromatography A}. Amsterdam: ELSEVIER SCIENCE BV, 2016, vol.~1466, SEP, p.~173-179. ISSN~0021-9673. Available from: https://dx.doi.org/10.1016/j.chroma.2016.08.042.
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