Preparation and Characterisation of Highly Stable Iron Oxide
Nanoparticles for Magnetic Resonance Imaging

J 2017

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

KOVÁŘ, David, Aneta MALÁ, Jitka VAŇÁČKOVÁ, Michal KALINA, Zdenka FOHLEROVÁ et. al.

Základní údaje

Originální název

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Autoři

KOVÁŘ, David (203 Česká republika, domácí), Aneta MALÁ (203 Česká republika), Jitka VAŇÁČKOVÁ (203 Česká republika, domácí), Michal KALINA (203 Česká republika), Zdenka FOHLEROVÁ (203 Česká republika), Antonín HLAVÁČEK (203 Česká republika, domácí), Zdeněk FARKA (203 Česká republika, domácí), Petr SKLÁDAL (203 Česká republika, domácí), Zenon STARČUK (203 Česká republika), Radovan JIŘÍK (203 Česká republika), Ondřej SLABÝ (203 Česká republika, garant, domácí) a Jaromír HUBÁLEK (203 Česká republika)

Vydání

Journal of Nanomaterials, London, Hindawi Publishing Corporation, 2017, 1687-4110

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.207

Kód RIV

RIV/00216224:14740/17:00094662

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1155/2017/7859289

UT WoS

000396144500001

Klíčová slova anglicky

ATOMIC-FORCE MICROSCOPY; CONTRAST AGENTS; ONE-STEP; MEDIA; MRI; SEPARATION; PARTICLES; SILICA; PROBES; CHARGE

Štítky

OA, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 6. 2017 14:10, Mgr. Eva Špillingová

Anotace

V originále

Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. Thecitrate-stabilised particles were produced with a narrow average size range below 2nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI)was then evaluated. The relaxivities (r(1),r(2)) and r(2)/r(1) ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T-2-contrast probe.

Návaznosti

GA16-18257S, projekt VaV

Název: Studium mechanizmu spojeného s nádorově supresorovou funkcí miR-215 a substituce této miRNA jako nové lečebné strategie u kolorektálního karcinomu

Investor: Grantová agentura ČR, Studium mechanizmu spojeného s nádorově supresorovou funkcí miR-215 a substituce této miRNA jako nové lečebné strategie u kolorektálního karcinomu

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

KOVÁŘ, David, Aneta MALÁ, Jitka VAŇÁČKOVÁ, Michal KALINA, Zdenka FOHLEROVÁ, Antonín HLAVÁČEK, Zdeněk FARKA, Petr SKLÁDAL, Zenon STARČUK, Radovan JIŘÍK, Ondřej SLABÝ a Jaromír HUBÁLEK. Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging. Journal of Nanomaterials. London: Hindawi Publishing Corporation, 2017, roč. 2017, neuvedeno, s. nestránkováno, 8 s. ISSN 1687-4110. Dostupné z: https://dx.doi.org/10.1155/2017/7859289.

@article{1374448,
   author = {Kovář, David and Malá, Aneta and Vaňáčková, Jitka and Kalina, Michal and Fohlerová, Zdenka and Hlaváček, Antonín and Farka, Zdeněk and Skládal, Petr and Starčuk, Zenon and Jiřík, Radovan and Slabý, Ondřej and Hubálek, Jaromír},
   article_location = {London},
   article_number = {neuvedeno},
   doi = {http://dx.doi.org/10.1155/2017/7859289},
   keywords = {ATOMIC-FORCE MICROSCOPY; CONTRAST AGENTS; ONE-STEP; MEDIA; MRI; SEPARATION; PARTICLES; SILICA; PROBES; CHARGE},
   language = {eng},
   issn = {1687-4110},
   journal = {Journal of Nanomaterials},
   title = {Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging},
   url = {https://www.hindawi.com/journals/jnm/2017/7859289/},
   volume = {2017},
   year = {2017}
}

TY  - JOUR
ID  - 1374448
AU  - Kovář, David - Malá, Aneta - Vaňáčková, Jitka - Kalina, Michal - Fohlerová, Zdenka - Hlaváček, Antonín - Farka, Zdeněk - Skládal, Petr - Starčuk, Zenon - Jiřík, Radovan - Slabý, Ondřej - Hubálek, Jaromír
PY  - 2017
TI  - Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
JF  - Journal of Nanomaterials
VL  - 2017
IS  - neuvedeno
SP  - nestránkováno
EP  - nestránkováno
PB  - Hindawi Publishing Corporation
SN  - 16874110
KW  - ATOMIC-FORCE MICROSCOPY
KW  - CONTRAST AGENTS
KW  - ONE-STEP
KW  - MEDIA
KW  - MRI
KW  - SEPARATION
KW  - PARTICLES
KW  - SILICA
KW  - PROBES
KW  - CHARGE
UR  - https://www.hindawi.com/journals/jnm/2017/7859289/
L2  - https://www.hindawi.com/journals/jnm/2017/7859289/
N2  - Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. Thecitrate-stabilised particles were produced with a narrow average size range below 2nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI)was then evaluated. The relaxivities (r(1),r(2)) and r(2)/r(1) ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T-2-contrast probe.
ER  -

KOVÁŘ, David, Aneta MALÁ, Jitka VAŇÁČKOVÁ, Michal KALINA, Zdenka FOHLEROVÁ, Antonín HLAVÁČEK, Zdeněk FARKA, Petr SKLÁDAL, Zenon STARČUK, Radovan JIŘÍK, Ondřej SLABÝ a Jaromír HUBÁLEK. Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging. \textit{Journal of Nanomaterials}. London: Hindawi Publishing Corporation, 2017, roč.~2017, neuvedeno, s.~nestránkováno, 8 s. ISSN~1687-4110. Dostupné z: https://dx.doi.org/10.1155/2017/7859289.

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