Meta-analysis of genome-wide association studies discovers
multiple loci for chronic lymphocytic leukemia

J 2016

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

BERNDT, Sonja I., Nicola J. CAMP, Christine F. SKIBOLA, Joseph VIJAI, Zhaoming WANG et. al.

Základní údaje

Originální název

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Autoři

BERNDT, Sonja I. (840 Spojené státy), Nicola J. CAMP (840 Spojené státy), Christine F. SKIBOLA (840 Spojené státy), Joseph VIJAI (840 Spojené státy), Zhaoming WANG (840 Spojené státy), Jian GU (840 Spojené státy), Alexandra NIETERS (276 Německo), Rachel S. KELLY (840 Spojené státy), Karin E. SMEDBY (752 Švédsko), Alain MONNEREAU (250 Francie), Wendy COZEN (840 Spojené státy), Angela COX (826 Velká Británie a Severní Irsko), Sophia S. WANG (840 Spojené státy), Qing LAN (840 Spojené státy), Lauren R. TERAS (840 Spojené státy), Moara MACHADO (840 Spojené státy), Meredith YEAGER (840 Spojené státy), Angela R. BROOKS-WILSON (124 Kanada), Patricia HARTGE (840 Spojené státy), Mark P. PURDUE (124 Kanada), Brenda M. BIRMANN (840 Spojené státy), Claire M. VAJDIC (36 Austrálie), Pierluigi COCCO (380 Itálie), Yawei ZHANG (840 Spojené státy), Graham G. GILES (36 Austrálie), Anne ZELENIUCH-JACQUOTTE (840 Spojené státy), Charles LAWRENCE (840 Spojené státy), Rebecca MONTALVAN (840 Spojené státy), Laurie BURDETT (840 Spojené státy), Amy HUTCHINSON (840 Spojené státy), Yuanqing YE (840 Spojené státy), Timothy G. CALL (840 Spojené státy), Tait D. SHANAFELT (840 Spojené státy), Anne J. NOVAK (840 Spojené státy), Neil E. KAY (840 Spojené státy), Mark LIEBOW (840 Spojené státy), Julie M. CUNNINGHAM (840 Spojené státy), Cristine ALLMER (840 Spojené státy), Henrik HJALGRIM (208 Dánsko), Hans-Olov ADAMI (752 Švédsko), Mads MELBYE (208 Dánsko), Bengt GLIMELIUS (752 Švédsko), Ellen T. CHANG (840 Spojené státy), Martha GLENN (840 Spojené státy), Karen CURTIN (840 Spojené státy), Lisa A. CANNON-ALBRIGHT (840 Spojené státy), W. Ryan DIVER (840 Spojené státy), Brian K. LINK (840 Spojené státy), George J. WEINER (840 Spojené státy), Lucia CONDE (840 Spojené státy), Paige M. BRACCI (840 Spojené státy), Jacques RIBY (840 Spojené státy), Donna K. ARNETT (840 Spojené státy), Degui ZHI (840 Spojené státy), Justin M. LEACH (840 Spojené státy), Elizabeth A. HOLLY (840 Spojené státy), Rebecca D. JACKSON (840 Spojené státy), Lesley F. TINKER (840 Spojené státy), Yolanda BENAVENTE (724 Španělsko), Núria SALA (724 Španělsko), Delphine CASABONNE (724 Španělsko), Nikolaus BECKER (276 Německo), Paolo BOFFETTA (840 Spojené státy), Paul BRENNAN (250 Francie), Lenka FORETOVÁ (203 Česká republika, garant, domácí), Marc MAYNADIE (250 Francie), James MCKAY (250 Francie), Anthony STAINES (372 Irsko), Kari G. CHAFFEE (840 Spojené státy), Sara J. ACHENBACH (840 Spojené státy), Celine M. VACHON (840 Spojené státy), Lynn R. GOLDIN (840 Spojené státy), Sara S. STROM (840 Spojené státy), Jose F. LEIS (840 Spojené státy), J. Brice WEINBERG (840 Spojené státy), Neil E. CAPORASO (840 Spojené státy), Aaron D. NORMAN (840 Spojené státy), Anneclaire J De ROOS (840 Spojené státy), Lindsay M. MORTON (840 Spojené státy), Richard K. SEVERSON (840 Spojené státy), Elio RIBOLI (826 Velká Británie a Severní Irsko), Paolo VINEIS (826 Velká Británie a Severní Irsko), Rudolph KAAKS (276 Německo), Giovanna MASALA (380 Itálie), Elisabete WEIDERPASS (578 Norsko), María-Dolores CHIRLAQUE (724 Španělsko), Roel C. H. VERMEULEN (528 Nizozemské království), Ruth C. TRAVIS (826 Velká Británie a Severní Irsko), Melissa C. SOUTHEY (36 Austrálie), Roger L. MILNE (36 Austrálie), Demetrius ALBANES (840 Spojené státy), Jarmo VIRTAMO (36 Austrálie), Stephanie WEINSTEIN (840 Spojené státy), Jacqueline CLAVEL (250 Francie), Tongzhang ZHENG (840 Spojené státy), Theodore R. HOLFORD (840 Spojené státy), Danylo J. VILLANO (840 Spojené státy), Ann MARIA (840 Spojené státy), John J. SPINELLI (124 Kanada), Randy D. GASCOYNE (124 Kanada), Joseph M. CONNORS (124 Kanada), Kimberly A. BERTRAND (840 Spojené státy), Edward GIOVANNUCCI (840 Spojené státy), Peter KRAFT (840 Spojené státy), Anne KRICKER (36 Austrálie), Jenny TURNER (36 Austrálie), Maria Grazia ENNAS (380 Itálie), Giovanni M. FERRI (380 Itálie), Lucia MILIGI (380 Itálie), Liming LIANG (840 Spojené státy), Baoshan MA (840 Spojené státy), Jinyan HUANG (840 Spojené státy), Simon CROUCH (826 Velká Británie a Severní Irsko), Ju-Hyun PARK (410 Korejská republika), Nilanjan CHATTERJEE (840 Spojené státy), Kari E. NORTH (840 Spojené státy), John A. SNOWDEN (826 Velká Británie a Severní Irsko), Josh WRIGHT (826 Velká Británie a Severní Irsko), Joseph F. FRAUMENI (840 Spojené státy), Kenneth OFFIT (840 Spojené státy), Xifeng WU (840 Spojené státy), Silvia de SANJOSE (724 Španělsko), James R. CERHAN (840 Spojené státy), Stephen J. CHANOCK (840 Spojené státy), Nathaniel ROTHMAN (840 Spojené státy) a Susan L. SLAGER (840 Spojené státy)

Vydání

Nature Communications, London, Nature Publishing Group, 2016, 2041-1723

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 12.124

Kód RIV

RIV/00216224:14110/16:00093816

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/ncomms10933

UT WoS

000371729200001

Klíčová slova anglicky

TRANSCRIPTION FACTOR EOMESODERMIN; FAS GENE-MUTATIONS; SUSCEPTIBILITY LOCI; FOLLICULAR LYMPHOMA; RISK; VARIANTS; EXPRESSION; BANK1; PRIORITIZATION; CLASSIFICATION

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 4. 2017 14:55, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P = 7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P = 2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.

Citovat

BERNDT, Sonja I., Nicola J. CAMP, Christine F. SKIBOLA, Joseph VIJAI, Zhaoming WANG, Jian GU, Alexandra NIETERS, Rachel S. KELLY, Karin E. SMEDBY, Alain MONNEREAU, Wendy COZEN, Angela COX, Sophia S. WANG, Qing LAN, Lauren R. TERAS, Moara MACHADO, Meredith YEAGER, Angela R. BROOKS-WILSON, Patricia HARTGE, Mark P. PURDUE, Brenda M. BIRMANN, Claire M. VAJDIC, Pierluigi COCCO, Yawei ZHANG, Graham G. GILES, Anne ZELENIUCH-JACQUOTTE, Charles LAWRENCE, Rebecca MONTALVAN, Laurie BURDETT, Amy HUTCHINSON, Yuanqing YE, Timothy G. CALL, Tait D. SHANAFELT, Anne J. NOVAK, Neil E. KAY, Mark LIEBOW, Julie M. CUNNINGHAM, Cristine ALLMER, Henrik HJALGRIM, Hans-Olov ADAMI, Mads MELBYE, Bengt GLIMELIUS, Ellen T. CHANG, Martha GLENN, Karen CURTIN, Lisa A. CANNON-ALBRIGHT, W. Ryan DIVER, Brian K. LINK, George J. WEINER, Lucia CONDE, Paige M. BRACCI, Jacques RIBY, Donna K. ARNETT, Degui ZHI, Justin M. LEACH, Elizabeth A. HOLLY, Rebecca D. JACKSON, Lesley F. TINKER, Yolanda BENAVENTE, Núria SALA, Delphine CASABONNE, Nikolaus BECKER, Paolo BOFFETTA, Paul BRENNAN, Lenka FORETOVÁ, Marc MAYNADIE, James MCKAY, Anthony STAINES, Kari G. CHAFFEE, Sara J. ACHENBACH, Celine M. VACHON, Lynn R. GOLDIN, Sara S. STROM, Jose F. LEIS, J. Brice WEINBERG, Neil E. CAPORASO, Aaron D. NORMAN, Anneclaire J De ROOS, Lindsay M. MORTON, Richard K. SEVERSON, Elio RIBOLI, Paolo VINEIS, Rudolph KAAKS, Giovanna MASALA, Elisabete WEIDERPASS, María-Dolores CHIRLAQUE, Roel C. H. VERMEULEN, Ruth C. TRAVIS, Melissa C. SOUTHEY, Roger L. MILNE, Demetrius ALBANES, Jarmo VIRTAMO, Stephanie WEINSTEIN, Jacqueline CLAVEL, Tongzhang ZHENG, Theodore R. HOLFORD, Danylo J. VILLANO, Ann MARIA, John J. SPINELLI, Randy D. GASCOYNE, Joseph M. CONNORS, Kimberly A. BERTRAND, Edward GIOVANNUCCI, Peter KRAFT, Anne KRICKER, Jenny TURNER, Maria Grazia ENNAS, Giovanni M. FERRI, Lucia MILIGI, Liming LIANG, Baoshan MA, Jinyan HUANG, Simon CROUCH, Ju-Hyun PARK, Nilanjan CHATTERJEE, Kari E. NORTH, John A. SNOWDEN, Josh WRIGHT, Joseph F. FRAUMENI, Kenneth OFFIT, Xifeng WU, Silvia de SANJOSE, James R. CERHAN, Stephen J. CHANOCK, Nathaniel ROTHMAN a Susan L. SLAGER. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Nature Communications. London: Nature Publishing Group, 2016, roč. 7, č. 10933, s. 1-9. ISSN 2041-1723. Dostupné z: https://dx.doi.org/10.1038/ncomms10933.

@article{1374862,
   author = {Berndt, Sonja I. and Camp, Nicola J. and Skibola, Christine F. and Vijai, Joseph and Wang, Zhaoming and Gu, Jian and Nieters, Alexandra and Kelly, Rachel S. and Smedby, Karin E. and Monnereau, Alain and Cozen, Wendy and Cox, Angela and Wang, Sophia S. and Lan, Qing and Teras, Lauren R. and Machado, Moara and Yeager, Meredith and BrooksandWilson, Angela R. and Hartge, Patricia and Purdue, Mark P. and Birmann, Brenda M. and Vajdic, Claire M. and Cocco, Pierluigi and Zhang, Yawei and Giles, Graham G. and ZeleniuchandJacquotte, Anne and Lawrence, Charles and Montalvan, Rebecca and Burdett, Laurie and Hutchinson, Amy and Ye, Yuanqing and Call, Timothy G. and Shanafelt, Tait D. and Novak, Anne J. and Kay, Neil E. and Liebow, Mark and Cunningham, Julie M. and Allmer, Cristine and Hjalgrim, Henrik and Adami, HansandOlov and Melbye, Mads and Glimelius, Bengt and Chang, Ellen T. and Glenn, Martha and Curtin, Karen and CannonandAlbright, Lisa A. and Diver, W. Ryan and Link, Brian K. and Weiner, George J. and Conde, Lucia and Bracci, Paige M. and Riby, Jacques and Arnett, Donna K. and Zhi, Degui and Leach, Justin M. and Holly, Elizabeth A. and Jackson, Rebecca D. and Tinker, Lesley F. and Benavente, Yolanda and Sala, Núria and Casabonne, Delphine and Becker, Nikolaus and Boffetta, Paolo and Brennan, Paul and Foretová, Lenka and Maynadie, Marc and McKay, James and Staines, Anthony and Chaffee, Kari G. and Achenbach, Sara J. and Vachon, Celine M. and Goldin, Lynn R. and Strom, Sara S. and Leis, Jose F. and Weinberg, J. Brice and Caporaso, Neil E. and Norman, Aaron D. and Roos, Anneclaire J De and Morton, Lindsay M. and Severson, Richard K. and Riboli, Elio and Vineis, Paolo and Kaaks, Rudolph and Masala, Giovanna and Weiderpass, Elisabete and Chirlaque, MaríaandDolores and Vermeulen, Roel C. H. and Travis, Ruth C. and Southey, Melissa C. and Milne, Roger L. and Albanes, Demetrius and Virtamo, Jarmo and Weinstein, Stephanie and Clavel, Jacqueline and Zheng, Tongzhang and Holford, Theodore R. and Villano, Danylo J. and Maria, Ann and Spinelli, John J. and Gascoyne, Randy D. and Connors, Joseph M. and Bertrand, Kimberly A. and Giovannucci, Edward and Kraft, Peter and Kricker, Anne and Turner, Jenny and Ennas, Maria Grazia and Ferri, Giovanni M. and Miligi, Lucia and Liang, Liming and Ma, Baoshan and Huang, Jinyan and Crouch, Simon and Park, JuandHyun and Chatterjee, Nilanjan and North, Kari E. and Snowden, John A. and Wright, Josh and Fraumeni, Joseph F. and Offit, Kenneth and Wu, Xifeng and Sanjose, Silvia de and Cerhan, James R. and Chanock, Stephen J. and Rothman, Nathaniel and Slager, Susan L.},
   article_location = {London},
   article_number = {10933},
   doi = {http://dx.doi.org/10.1038/ncomms10933},
   keywords = {TRANSCRIPTION FACTOR EOMESODERMIN; FAS GENE-MUTATIONS; SUSCEPTIBILITY LOCI; FOLLICULAR LYMPHOMA; RISK; VARIANTS; EXPRESSION; BANK1; PRIORITIZATION; CLASSIFICATION},
   language = {eng},
   issn = {2041-1723},
   journal = {Nature Communications},
   title = {Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia},
   volume = {7},
   year = {2016}
}

TY  - JOUR
ID  - 1374862
AU  - Berndt, Sonja I. - Camp, Nicola J. - Skibola, Christine F. - Vijai, Joseph - Wang, Zhaoming - Gu, Jian - Nieters, Alexandra - Kelly, Rachel S. - Smedby, Karin E. - Monnereau, Alain - Cozen, Wendy - Cox, Angela - Wang, Sophia S. - Lan, Qing - Teras, Lauren R. - Machado, Moara - Yeager, Meredith - Brooks-Wilson, Angela R. - Hartge, Patricia - Purdue, Mark P. - Birmann, Brenda M. - Vajdic, Claire M. - Cocco, Pierluigi - Zhang, Yawei - Giles, Graham G. - Zeleniuch-Jacquotte, Anne - Lawrence, Charles - Montalvan, Rebecca - Burdett, Laurie - Hutchinson, Amy - Ye, Yuanqing - Call, Timothy G. - Shanafelt, Tait D. - Novak, Anne J. - Kay, Neil E. - Liebow, Mark - Cunningham, Julie M. - Allmer, Cristine - Hjalgrim, Henrik - Adami, Hans-Olov - Melbye, Mads - Glimelius, Bengt - Chang, Ellen T. - Glenn, Martha - Curtin, Karen - Cannon-Albright, Lisa A. - Diver, W. Ryan - Link, Brian K. - Weiner, George J. - Conde, Lucia - Bracci, Paige M. - Riby, Jacques - Arnett, Donna K. - Zhi, Degui - Leach, Justin M. - Holly, Elizabeth A. - Jackson, Rebecca D. - Tinker, Lesley F. - Benavente, Yolanda - Sala, Núria - Casabonne, Delphine - Becker, Nikolaus - Boffetta, Paolo - Brennan, Paul - Foretová, Lenka - Maynadie, Marc - McKay, James - Staines, Anthony - Chaffee, Kari G. - Achenbach, Sara J. - Vachon, Celine M. - Goldin, Lynn R. - Strom, Sara S. - Leis, Jose F. - Weinberg, J. Brice - Caporaso, Neil E. - Norman, Aaron D. - Roos, Anneclaire J De - Morton, Lindsay M. - Severson, Richard K. - Riboli, Elio - Vineis, Paolo - Kaaks, Rudolph - Masala, Giovanna - Weiderpass, Elisabete - Chirlaque, María-Dolores - Vermeulen, Roel C. H. - Travis, Ruth C. - Southey, Melissa C. - Milne, Roger L. - Albanes, Demetrius - Virtamo, Jarmo - Weinstein, Stephanie - Clavel, Jacqueline - Zheng, Tongzhang - Holford, Theodore R. - Villano, Danylo J. - Maria, Ann - Spinelli, John J. - Gascoyne, Randy D. - Connors, Joseph M. - Bertrand, Kimberly A. - Giovannucci, Edward - Kraft, Peter - Kricker, Anne - Turner, Jenny - Ennas, Maria Grazia - Ferri, Giovanni M. - Miligi, Lucia - Liang, Liming - Ma, Baoshan - Huang, Jinyan - Crouch, Simon - Park, Ju-Hyun - Chatterjee, Nilanjan - North, Kari E. - Snowden, John A. - Wright, Josh - Fraumeni, Joseph F. - Offit, Kenneth - Wu, Xifeng - Sanjose, Silvia de - Cerhan, James R. - Chanock, Stephen J. - Rothman, Nathaniel - Slager, Susan L.
PY  - 2016
TI  - Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
JF  - Nature Communications
VL  - 7
IS  - 10933
SP  - 1-9
EP  - 1-9
PB  - Nature Publishing Group
SN  - 20411723
KW  - TRANSCRIPTION FACTOR EOMESODERMIN
KW  - FAS GENE-MUTATIONS
KW  - SUSCEPTIBILITY LOCI
KW  - FOLLICULAR LYMPHOMA
KW  - RISK
KW  - VARIANTS
KW  - EXPRESSION
KW  - BANK1
KW  - PRIORITIZATION
KW  - CLASSIFICATION
N2  - Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P = 7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P = 2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
ER  -

BERNDT, Sonja I., Nicola J. CAMP, Christine F. SKIBOLA, Joseph VIJAI, Zhaoming WANG, Jian GU, Alexandra NIETERS, Rachel S. KELLY, Karin E. SMEDBY, Alain MONNEREAU, Wendy COZEN, Angela COX, Sophia S. WANG, Qing LAN, Lauren R. TERAS, Moara MACHADO, Meredith YEAGER, Angela R. BROOKS-WILSON, Patricia HARTGE, Mark P. PURDUE, Brenda M. BIRMANN, Claire M. VAJDIC, Pierluigi COCCO, Yawei ZHANG, Graham G. GILES, Anne ZELENIUCH-JACQUOTTE, Charles LAWRENCE, Rebecca MONTALVAN, Laurie BURDETT, Amy HUTCHINSON, Yuanqing YE, Timothy G. CALL, Tait D. SHANAFELT, Anne J. NOVAK, Neil E. KAY, Mark LIEBOW, Julie M. CUNNINGHAM, Cristine ALLMER, Henrik HJALGRIM, Hans-Olov ADAMI, Mads MELBYE, Bengt GLIMELIUS, Ellen T. CHANG, Martha GLENN, Karen CURTIN, Lisa A. CANNON-ALBRIGHT, W. Ryan DIVER, Brian K. LINK, George J. WEINER, Lucia CONDE, Paige M. BRACCI, Jacques RIBY, Donna K. ARNETT, Degui ZHI, Justin M. LEACH, Elizabeth A. HOLLY, Rebecca D. JACKSON, Lesley F. TINKER, Yolanda BENAVENTE, Núria SALA, Delphine CASABONNE, Nikolaus BECKER, Paolo BOFFETTA, Paul BRENNAN, Lenka FORETOVÁ, Marc MAYNADIE, James MCKAY, Anthony STAINES, Kari G. CHAFFEE, Sara J. ACHENBACH, Celine M. VACHON, Lynn R. GOLDIN, Sara S. STROM, Jose F. LEIS, J. Brice WEINBERG, Neil E. CAPORASO, Aaron D. NORMAN, Anneclaire J De ROOS, Lindsay M. MORTON, Richard K. SEVERSON, Elio RIBOLI, Paolo VINEIS, Rudolph KAAKS, Giovanna MASALA, Elisabete WEIDERPASS, María-Dolores CHIRLAQUE, Roel C. H. VERMEULEN, Ruth C. TRAVIS, Melissa C. SOUTHEY, Roger L. MILNE, Demetrius ALBANES, Jarmo VIRTAMO, Stephanie WEINSTEIN, Jacqueline CLAVEL, Tongzhang ZHENG, Theodore R. HOLFORD, Danylo J. VILLANO, Ann MARIA, John J. SPINELLI, Randy D. GASCOYNE, Joseph M. CONNORS, Kimberly A. BERTRAND, Edward GIOVANNUCCI, Peter KRAFT, Anne KRICKER, Jenny TURNER, Maria Grazia ENNAS, Giovanni M. FERRI, Lucia MILIGI, Liming LIANG, Baoshan MA, Jinyan HUANG, Simon CROUCH, Ju-Hyun PARK, Nilanjan CHATTERJEE, Kari E. NORTH, John A. SNOWDEN, Josh WRIGHT, Joseph F. FRAUMENI, Kenneth OFFIT, Xifeng WU, Silvia de SANJOSE, James R. CERHAN, Stephen J. CHANOCK, Nathaniel ROTHMAN a Susan L. SLAGER. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. \textit{Nature Communications}. London: Nature Publishing Group, 2016, roč.~7, č.~10933, s.~1-9. ISSN~2041-1723. Dostupné z: https://dx.doi.org/10.1038/ncomms10933.

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