J 2017

Proliferative kidney disease in rainbow trout (Oncorhynchus mykiss) under intensive breeding conditions: Pathogenesis and haematological and immune parameters

PALÍKOVÁ, Miroslava, Ivana PAPEŽÍKOVÁ, Zdeňka MARKOVÁ, Stanislav NAVRÁTIL, Jan MAREŠ et. al.

Základní údaje

Originální název

Proliferative kidney disease in rainbow trout (Oncorhynchus mykiss) under intensive breeding conditions: Pathogenesis and haematological and immune parameters

Autoři

PALÍKOVÁ, Miroslava (203 Česká republika, garant), Ivana PAPEŽÍKOVÁ (203 Česká republika), Zdeňka MARKOVÁ (203 Česká republika), Stanislav NAVRÁTIL (203 Česká republika), Jan MAREŠ (203 Česká republika), Lukáš MAREŠ (203 Česká republika), Libor VOJTEK (203 Česká republika, domácí), Pavel HYRŠL (203 Česká republika, domácí), Eva JELÍNKOVÁ (203 Česká republika) a Heike SCHMIDT-POSTHAUS (756 Švýcarsko)

Vydání

Veterinary Parasitology, Amsterdam, Elsevier Science, 2017, 0304-4017

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.422

Kód RIV

RIV/00216224:14310/17:00096260

Organizační jednotka

Přírodovědecká fakulta

DOI

UT WoS

000403117800002

Klíčová slova česky

Proliferativní onemocnění ledvin; pstruh duhový; oxidační vzplanutí; celkové imunoglobuliny; aktivita komplementu; histologie; imunochemie

Klíčová slova anglicky

Proliferative kidney disease; Rainbow trout; Oxidative burst; Total immunoglobulins; Complement activity; Histology; Immunohistochemistry

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 10. 4. 2018 23:03, Ing. Nicole Zrilić

Anotace

V originále

Proliferative kidney disease (PKD) is an endoparasitic disease of salmonid fish caused by Tetracapsuloides bryosalmonae (Myxozoa: Malacosporea). This study presents a comprehensive view on PKD development in rainbow trout (Oncorhynchus mykiss) reared at an intensive fish breeding facility, with focus on mortality, pathology/histopathology, haematological findings and immune functions. Diseased and reference fish were sampled monthly and time course of natural infection was followed up from the onset of clinical signs (September 2014) to full recovery (January 2015). PKD- associated cumulative mortality was 30% with a peak value in October, while immunohistochemical testing indicated a continuous significant decrease in T. bryosalmonae numbers from September to December; with no parasites detected in January. During peak clinical infection, a significant decrease in red blood cell counts, haematocrit values, haemoglobin concentration, along with a reduction in lymphocytes and a significant phagocyte elevation corresponding with an increase in phagocyte oxidative burst were measured in comparison to control animals. Complement activity and total immunoglobulin plasma concentrations were also elevated, though only during the initial monitoring period (September). Individuals surviving PKD, recovered and were able to fully regenerate both renal structure and haematopoietic parameters to normal levels. Changes in the red blood cell parameters indicate anaemia and a decreased oxygen transportation capacity during the clinical disease phase. Together with an increased oxygen demand at higher temperatures and decreased oxygen solubility this could lead to decompensation and elevated mortality. The stimulation of immune parameters, and especially oxidative phagocytic burst, is likely to have had a strong effect on both, regeneration and elimination of the pathogenic agent.