LA-ICP-MS as a tool for imaging of tumour tissue

VACULOVIČ, Tomáš, Michaela TVRDOŇOVÁ, Michal MASAŘÍK, Hana POLANSKÁ, Markéta SVOBODOVÁ and Viktor KANICKÝ. LA-ICP-MS as a tool for imaging of tumour tissue. In European Workshop on Laser Ablation. 2016.

Basic information

• Original name: LA-ICP-MS as a tool for imaging of tumour tissue
• Authors: VACULOVIČ, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Michaela TVRDOŇOVÁ (203 Czech Republic, belonging to the institution), Michal MASAŘÍK (203 Czech Republic, belonging to the institution), Hana POLANSKÁ (203 Czech Republic, belonging to the institution), Markéta SVOBODOVÁ (203 Czech Republic) and Viktor KANICKÝ (203 Czech Republic).
• Edition: European Workshop on Laser Ablation, 2016.

Other information

• Original language: English
• Type of outcome: Presentations at conferences
• Field of Study: 10406 Analytical chemistry
• Country of publisher: Slovenia
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/16:00093835
• Organization unit: Faculty of Science
• Keywords in English: laser-matter interaction; particle formation and transport phenomena; mapping strategies; standardization; isotope ratio analysis
• Tags: AKR
• Tags: International impact

Abstract

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) allows study of lateral distribution of specific elements (Cu, Zn, Pb, Pt) in very low concentration levels (mg/kg) in tumor tissues. Presented work is focused on study of laser ablation parameters (scan speed and laser spot diameter) on lateral resolution and limit of detection of LA-ICP-MS. The utilization of LA-ICP-MS for bioimaging purpose will be demonstrated on mice tumour tissues analysis which are treated by various Pt-based cytostatics (carbo-, oxali- and cis-Pt).

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology