| FELIX, Jan, Eaazhisai KANDIAH, Steven DE MUNCK, Yehudi BLOCH, Gydo C. P. VAN ZUNDERT, Kris PAUWELS, Ann DANSERCOER, Katarína VONDRÁŠKOVÁ, Randy J. READ, Alexandre M. J. J. BONVIN, Bjorn VERGAUWEN, Kenneth VERSTRAETE, Irina GUTSCHE a Savvas N. SAVVIDES. Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF. Nature Communications. London: Nature Publishing Group, 2016, roč. 7, November, s. nestránkováno, 13 s. ISSN 2041-1723. Dostupné z: https://dx.doi.org/10.1038/ncomms13228. |
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@article{1375135,
author = {Felix, Jan and Kandiah, Eaazhisai and De Munck, Steven and Bloch, Yehudi and van Zundert, Gydo C. P. and Pauwels, Kris and Dansercoer, Ann and Vondrášková, Katarína and Read, Randy J. and Bonvin, Alexandre M. J. J. and Vergauwen, Bjorn and Verstraete, Kenneth and Gutsche, Irina and Savvides, Savvas N.},
article_location = {London},
article_number = {November},
doi = {http://dx.doi.org/10.1038/ncomms13228},
keywords = {CHEMOKINE-BINDING-PROTEIN; COLONY-STIMULATING FACTOR; ORF VIRUS; CRYSTAL-STRUCTURE; VACCINIA VIRUS; COWPOX VIRUS; INTERLEUKIN-2; COMPLEX; INHIBITOR; SYSTEM},
language = {eng},
issn = {2041-1723},
journal = {Nature Communications},
title = {Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF},
url = {http://www.nature.com/articles/ncomms13228},
volume = {7},
year = {2016}
}
TY - JOUR
ID - 1375135
AU - Felix, Jan - Kandiah, Eaazhisai - De Munck, Steven - Bloch, Yehudi - van Zundert, Gydo C. P. - Pauwels, Kris - Dansercoer, Ann - Vondrášková, Katarína - Read, Randy J. - Bonvin, Alexandre M. J. J. - Vergauwen, Bjorn - Verstraete, Kenneth - Gutsche, Irina - Savvides, Savvas N.
PY - 2016
TI - Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF
JF - Nature Communications
VL - 7
IS - November
SP - nestránkováno
EP - nestránkováno
PB - Nature Publishing Group
SN - 20411723
KW - CHEMOKINE-BINDING-PROTEIN
KW - COLONY-STIMULATING FACTOR
KW - ORF VIRUS
KW - CRYSTAL-STRUCTURE
KW - VACCINIA VIRUS
KW - COWPOX VIRUS
KW - INTERLEUKIN-2
KW - COMPLEX
KW - INHIBITOR
KW - SYSTEM
UR - http://www.nature.com/articles/ncomms13228
L2 - http://www.nature.com/articles/ncomms13228
N2 - Subversion of the host immune system by viruses is often mediated by molecular decoys that sequester host proteins pivotal to mounting effective immune responses. The widespread mammalian pathogen parapox Orf virus deploys GIF, a member of the poxvirus immune evasion superfamily, to antagonize GM-CSF (granulocyte macrophage colony-stimulating factor) and IL-2 (interleukin-2), two pleiotropic cytokines of the mammalian immune system. However, structural and mechanistic insights into the unprecedented functional duality of GIF have remained elusive. Here we reveal that GIF employs a dimeric binding platform that sequesters two copies of its target cytokines with high affinity and slow dissociation kinetics to yield distinct complexes featuring mutually exclusive interaction footprints. We illustrate how GIF serves as a competitive decoy receptor by leveraging binding hotspots underlying the cognate receptor interactions of GM-CSF and IL-2, without sharing any structural similarity with the cytokine receptors. Our findings contribute to the tracing of novel molecular mimicry mechanisms employed by pathogenic viruses.
ER -
FELIX, Jan, Eaazhisai KANDIAH, Steven DE MUNCK, Yehudi BLOCH, Gydo C. P. VAN ZUNDERT, Kris PAUWELS, Ann DANSERCOER, Katarína VONDRÁŠKOVÁ, Randy J. READ, Alexandre M. J. J. BONVIN, Bjorn VERGAUWEN, Kenneth VERSTRAETE, Irina GUTSCHE a Savvas N. SAVVIDES. Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF. \textit{Nature Communications}. London: Nature Publishing Group, 2016, roč.~7, November, s.~nestránkováno, 13 s. ISSN~2041-1723. Dostupné z: https://dx.doi.org/10.1038/ncomms13228.
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