2018
No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe
DAVIS, Ann, Meng-Hua TAO, Jia CHEN, Ghislaine SCELO, Vladimir BENCKO et. al.Základní údaje
Originální název
No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe
Autoři
DAVIS, Ann (840 Spojené státy), Meng-Hua TAO (840 Spojené státy, garant), Jia CHEN (840 Spojené státy), Ghislaine SCELO (250 Francie), Vladimir BENCKO (203 Česká republika), Eleonora FABIANOVA (703 Slovensko), Lenka FORETOVÁ (203 Česká republika, domácí), Vladimir JANOUT (203 Česká republika), Jolanta LISSOWSKA (616 Polsko), Dana MATES (642 Rumunsko), Ioan N MATES (642 Rumunsko), Peter RUDNAI (348 Maďarsko), David ZARIDZE (643 Rusko) a Paolo BOFFETTA (840 Spojené státy)
Vydání
European Journal of Cancer Prevention, Philadelphia, Lippincott Williams & Wilkins, 2018, 0959-8278
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30204 Oncology
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 2.330
Kód RIV
RIV/00216224:14110/18:00101981
Organizační jednotka
Lékařská fakulta
UT WoS
000417289000001
Klíčová slova anglicky
epidemiology; global methylation; lung cancer; never-smoking women
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 21. 3. 2019 12:06, Soňa Böhmová
Anotace
V originále
Alterations in global DNA methylation have been suggested to play an important role in cancer development. We evaluated the association of global DNA methylation in peripheral blood with the risk of lung cancer in nonsmoking women from six countries in Central and Eastern Europe. This multicenter case–control study included primary, incident lung cancer cases diagnosed from 1998 to 2001 and controls frequency-matched for geographic area, sex, and age. Global methylation was assessed in peripheral blood DNA from 83 nonsmoking female cases and 181 nonsmoking female controls using the luminometric methylation assay (LUMA). Unconditional logistic regression models were used to estimate associations between DNA methylation in the blood and the risk of lung cancer. LUMA methylation level was not associated with the risk of lung cancer in nonsmoking women. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. In our study of nonsmoking women, the LUMA methylation level in peripheral blood was not associated with the risk of lung cancer. Our findings do not support an association of global blood DNA methylation with the risk of lung cancer in nonsmoking women.