J 2018

No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe

DAVIS, Ann, Meng-Hua TAO, Jia CHEN, Ghislaine SCELO, Vladimir BENCKO et. al.

Základní údaje

Originální název

No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe

Autoři

DAVIS, Ann (840 Spojené státy), Meng-Hua TAO (840 Spojené státy, garant), Jia CHEN (840 Spojené státy), Ghislaine SCELO (250 Francie), Vladimir BENCKO (203 Česká republika), Eleonora FABIANOVA (703 Slovensko), Lenka FORETOVÁ (203 Česká republika, domácí), Vladimir JANOUT (203 Česká republika), Jolanta LISSOWSKA (616 Polsko), Dana MATES (642 Rumunsko), Ioan N MATES (642 Rumunsko), Peter RUDNAI (348 Maďarsko), David ZARIDZE (643 Rusko) a Paolo BOFFETTA (840 Spojené státy)

Vydání

European Journal of Cancer Prevention, Philadelphia, Lippincott Williams & Wilkins, 2018, 0959-8278

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.330

Kód RIV

RIV/00216224:14110/18:00101981

Organizační jednotka

Lékařská fakulta

UT WoS

000417289000001

Klíčová slova anglicky

epidemiology; global methylation; lung cancer; never-smoking women

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 21. 3. 2019 12:06, Soňa Böhmová

Anotace

V originále

Alterations in global DNA methylation have been suggested to play an important role in cancer development. We evaluated the association of global DNA methylation in peripheral blood with the risk of lung cancer in nonsmoking women from six countries in Central and Eastern Europe. This multicenter case–control study included primary, incident lung cancer cases diagnosed from 1998 to 2001 and controls frequency-matched for geographic area, sex, and age. Global methylation was assessed in peripheral blood DNA from 83 nonsmoking female cases and 181 nonsmoking female controls using the luminometric methylation assay (LUMA). Unconditional logistic regression models were used to estimate associations between DNA methylation in the blood and the risk of lung cancer. LUMA methylation level was not associated with the risk of lung cancer in nonsmoking women. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. In our study of nonsmoking women, the LUMA methylation level in peripheral blood was not associated with the risk of lung cancer. Our findings do not support an association of global blood DNA methylation with the risk of lung cancer in nonsmoking women.