Human Treponema pallidum 11q/j isolate belongs to subsp.
endemicum but contains two loci with a sequence in TP0548 and
TP0488 similar to subsp. pertenue and subsp. pallidum,
respectively

J 2017

Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively

MIKALOVÁ, Lenka, Michal STROUHAL, Jan OPPELT, Philippe Alain GRANGE, Michel JANIER et. al.

Základní údaje

Originální název

Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively

Autoři

MIKALOVÁ, Lenka (203 Česká republika, domácí), Michal STROUHAL (203 Česká republika, domácí), Jan OPPELT (203 Česká republika, domácí), Philippe Alain GRANGE (250 Francie), Michel JANIER (250 Francie), Nadjet BENHADDOU (250 Francie), Nicolas DUPIN (250 Francie) a David ŠMAJS (203 Česká republika, garant, domácí)

Vydání

PLoS neglected tropical diseases, San Francisco, Public Library of Science, 2017, 1935-2735

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.367

Kód RIV

RIV/00216224:14110/17:00094671

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1371/journal.pntd.0005434

UT WoS

000402251300033

Klíčová slova anglicky

Treponema pallidum

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 3. 2018 11:48, Mgr. Vincent Belej

Anotace

V originále

The TEN 11q/j isolate was characterized using nested PCR followed by Sanger sequencing and/or direct Illumina sequencing. Altogether, 44 chromosomal regions were analyzed. Overall, the 11q/j isolate clustered with TEN strains Bosnia A and Iraq B as expected from previous TEN classification of the 11q/j isolate. However, the 11q/j sequence in a 505 bp-long region at the TP0488 locus was similar to Treponema pallidum subsp. pallidum (TPA) strains, but not to TEN Bosnia A and Iraq B sequences, suggesting a recombination event at this locus. Similarly, the 11q/j sequence in a 613 bp-long region at the TP0548 locus was similar to Treponema pallidum subsp. pertenue (TPE) strains, but not to TEN sequences.

Návaznosti

GAP302/12/0574, projekt VaV

Název: Celogenomové sekvencování v analýze genomů a transkriptomů patogenních bakterií rodu Treponema

Investor: Grantová agentura ČR, Celogenomové sekvencování v analýze genomů a transkriptomů patogenních bakterií rodu Treponema

GA17-25455S, projekt VaV

Název: Studium genomů patogenních treponem na základě analýzy jednotlivých buněk

Investor: Grantová agentura ČR, Studium genomů patogenních treponem na základě analýzy jednotlivých buněk

GP14-29596P, projekt VaV

Název: Genomová variabilita treponem během experimentální infekce

Investor: Grantová agentura ČR, Genomová variabilita treponem během experimentální infekce

ROZV/20/LF/2015, interní kód MU

Název: LF - Příspěvek IP 2015

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek IP 2015

ROZV/24/LF/2016, interní kód MU

Název: LF - Příspěvek IP 2016

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek IP 2016

Citovat

MIKALOVÁ, Lenka, Michal STROUHAL, Jan OPPELT, Philippe Alain GRANGE, Michel JANIER, Nadjet BENHADDOU, Nicolas DUPIN a David ŠMAJS. Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively. PLoS neglected tropical diseases. San Francisco: Public Library of Science, 2017, roč. 11, č. 3, s. 1-14. ISSN 1935-2735. Dostupné z: https://dx.doi.org/10.1371/journal.pntd.0005434.

@article{1375593,
   author = {Mikalová, Lenka and Strouhal, Michal and Oppelt, Jan and Grange, Philippe Alain and Janier, Michel and Benhaddou, Nadjet and Dupin, Nicolas and Šmajs, David},
   article_location = {San Francisco},
   article_number = {3},
   doi = {http://dx.doi.org/10.1371/journal.pntd.0005434},
   keywords = {Treponema pallidum},
   language = {eng},
   issn = {1935-2735},
   journal = {PLoS neglected tropical diseases},
   title = {Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively},
   url = {http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005434},
   volume = {11},
   year = {2017}
}

TY  - JOUR
ID  - 1375593
AU  - Mikalová, Lenka - Strouhal, Michal - Oppelt, Jan - Grange, Philippe Alain - Janier, Michel - Benhaddou, Nadjet - Dupin, Nicolas - Šmajs, David
PY  - 2017
TI  - Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively
JF  - PLoS neglected tropical diseases
VL  - 11
IS  - 3
SP  - 1-14
EP  - 1-14
PB  - Public Library of Science
SN  - 19352735
KW  - Treponema pallidum
UR  - http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005434
N2  - The TEN 11q/j isolate was characterized using nested PCR followed by Sanger sequencing and/or direct Illumina sequencing. Altogether, 44 chromosomal regions were analyzed. Overall, the 11q/j isolate clustered with TEN strains Bosnia A and Iraq B as expected from previous TEN classification of the 11q/j isolate. However, the 11q/j sequence in a 505 bp-long region at the TP0488 locus was similar to Treponema pallidum subsp. pallidum (TPA) strains, but not to TEN Bosnia A and Iraq B sequences, suggesting a recombination event at this locus. Similarly, the 11q/j sequence in a 613 bp-long region at the TP0548 locus was similar to Treponema pallidum subsp. pertenue (TPE) strains, but not to TEN sequences.
ER  -

MIKALOVÁ, Lenka, Michal STROUHAL, Jan OPPELT, Philippe Alain GRANGE, Michel JANIER, Nadjet BENHADDOU, Nicolas DUPIN a David ŠMAJS. Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively. \textit{PLoS neglected tropical diseases}. San Francisco: Public Library of Science, 2017, roč.~11, č.~3, s.~1-14. ISSN~1935-2735. Dostupné z: https://dx.doi.org/10.1371/journal.pntd.0005434.

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