Contrasting patterns of polymorphism and selection in
bacterial-sensing toll-like receptor 4 in two house mouse
subspecies

J 2014

Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies

FORNŮSKOVÁ, Alena, Josef BRYJA, Michal VINKLER, Miloš MACHOLÁN, Jaroslav PIÁLEK et. al.

Základní údaje

Originální název

Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies

Autoři

FORNŮSKOVÁ, Alena (203 Česká republika, garant, domácí), Josef BRYJA (203 Česká republika, domácí), Michal VINKLER (203 Česká republika), Miloš MACHOLÁN (203 Česká republika) a Jaroslav PIÁLEK (203 Česká republika)

Vydání

ECOLOGY AND EVOLUTION, 2014, 2045-7758

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.320

Kód RIV

RIV/00216224:14310/14:00094001

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1002/ece3.1137

UT WoS

000340146300010

Klíčová slova anglicky

Adaptive evolution; arms race; directional selection; host-pathogen interaction; MAMPs; Mus musculus; parasite-mediated selection; pattern-recognition receptors

Štítky

AKR, rivok

Změněno: 8. 3. 2018 13:07, Mgr. Lucie Jarošová, DiS.

Anotace

V originále

Detailed investigation of variation in genes involved in pathogen recognition is crucial for understanding co-evolutionary processes between parasites and their hosts. Triggering immediate innate response to invading microbes, Toll-like receptors (TLRs) belong presently among the best-studied receptors of vertebrate immunity. TLRs exhibit remarkable interspecific variation and also intra-specific polymorphism is well documented. In humans and laboratory mice, several studies have recently shown that single amino acid substitution may significantly alter receptor function. Unfortunately, data concerning polymorphism in free-living species are still surprisingly scarce. In this study, we analyzed the polymorphism of Toll-like receptor 4 (Tlr4) over the Palearctic range of house mouse (Mus musculus). Our results reveal contrasting evolutionary patterns between the two recently (0.5 million years ago) diverged house mouse subspecies: M. m. domesticus (Mmd) and M. m. musculus (Mmm). Comparison with cytochrome b indicates strong directional selection in Mmd Tlr4. Throughout the whole Mmd western Palaearctic region, a single variant of the ligand-binding region is spread, encoded mainly by one dominant haplotype (71% of Mmd). In contrast, Tlr4 in Mmm is much more polymorphic with several haplotypes at intermediate frequencies. Moreover, we also found clear signals of recombination between two principal haplogroups in Mmm, and we identified eight sites under positive selection in our dataset. Our results suggest that observed differences in Tlr4 diversity may be attributed to contrasting parasite-mediated selection acting in the two subspecies.

Citovat

FORNŮSKOVÁ, Alena, Josef BRYJA, Michal VINKLER, Miloš MACHOLÁN a Jaroslav PIÁLEK. Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies. ECOLOGY AND EVOLUTION. 2014, roč. 4, č. 14, s. 2931-2944. ISSN 2045-7758. Dostupné z: https://dx.doi.org/10.1002/ece3.1137.

@article{1376674,
   author = {Fornůsková, Alena and Bryja, Josef and Vinkler, Michal and Macholán, Miloš and Piálek, Jaroslav},
   article_number = {14},
   doi = {http://dx.doi.org/10.1002/ece3.1137},
   keywords = {Adaptive evolution; arms race; directional selection; host-pathogen interaction; MAMPs; Mus musculus; parasite-mediated selection; pattern-recognition receptors},
   language = {eng},
   issn = {2045-7758},
   journal = {ECOLOGY AND EVOLUTION},
   title = {Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies},
   volume = {4},
   year = {2014}
}

TY  - JOUR
ID  - 1376674
AU  - Fornůsková, Alena - Bryja, Josef - Vinkler, Michal - Macholán, Miloš - Piálek, Jaroslav
PY  - 2014
TI  - Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies
JF  - ECOLOGY AND EVOLUTION
VL  - 4
IS  - 14
SP  - 2931-2944
EP  - 2931-2944
SN  - 20457758
KW  - Adaptive evolution
KW  - arms race
KW  - directional selection
KW  - host-pathogen interaction
KW  - MAMPs
KW  - Mus musculus
KW  - parasite-mediated selection
KW  - pattern-recognition receptors
N2  - Detailed investigation of variation in genes involved in pathogen recognition is crucial for understanding co-evolutionary processes between parasites and their hosts. Triggering immediate innate response to invading microbes, Toll-like receptors (TLRs) belong presently among the best-studied receptors of vertebrate immunity. TLRs exhibit remarkable interspecific variation and also intra-specific polymorphism is well documented. In humans and laboratory mice, several studies have recently shown that single amino acid substitution may significantly alter receptor function. Unfortunately, data concerning polymorphism in free-living species are still surprisingly scarce. In this study, we analyzed the polymorphism of Toll-like receptor 4 (Tlr4) over the Palearctic range of house mouse (Mus musculus). Our results reveal contrasting evolutionary patterns between the two recently (0.5 million years ago) diverged house mouse subspecies: M. m. domesticus (Mmd) and M. m. musculus (Mmm). Comparison with cytochrome b indicates strong directional selection in Mmd Tlr4. Throughout the whole Mmd western Palaearctic region, a single variant of the ligand-binding region is spread, encoded mainly by one dominant haplotype (71% of Mmd). In contrast, Tlr4 in Mmm is much more polymorphic with several haplotypes at intermediate frequencies. Moreover, we also found clear signals of recombination between two principal haplogroups in Mmm, and we identified eight sites under positive selection in our dataset. Our results suggest that observed differences in Tlr4 diversity may be attributed to contrasting parasite-mediated selection acting in the two subspecies.
ER  -

FORNŮSKOVÁ, Alena, Josef BRYJA, Michal VINKLER, Miloš MACHOLÁN a Jaroslav PIÁLEK. Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies. \textit{ECOLOGY AND EVOLUTION}. 2014, roč.~4, č.~14, s.~2931-2944. ISSN~2045-7758. Dostupné z: https://dx.doi.org/10.1002/ece3.1137.

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