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@article{1377001, author = {Kushkevych, Ivan and Kollár, Petr and Ferreira, Ana Luísa and Palma, Diogo}, article_number = {14(2)}, doi = {http://dx.doi.org/10.1016/j.jab.2016.01.005}, keywords = {Sulfate-reducing bacteria; Desulfovibrio piger; Desulfomicrobium sp.; Salicylamides; Bowel disease; Lipophilicity; Structure–activity relationships}, language = {eng}, issn = {1214-021X}, journal = {Journal of Applied Biomedicine}, note = {doc. Kushkevych nemá na WoS afiliaci na MU, nýbrž na Univer. veterinárního lékařství. Nelze přenášet do RIV bez domácího autora!}, title = {Antimicrobial effect of salicylamide derivatives against intestinal sulfate-reducing bacteria}, url = {http://dx.doi.org/10.1016/j.jab.2016.01.005}, volume = {2016}, year = {2016} }
TY - JOUR ID - 1377001 AU - Kushkevych, Ivan - Kollár, Petr - Ferreira, Ana Luísa - Palma, Diogo PY - 2016 TI - Antimicrobial effect of salicylamide derivatives against intestinal sulfate-reducing bacteria JF - Journal of Applied Biomedicine VL - 2016 IS - 14(2) SP - 125-130 EP - 125-130 SN - 1214021X N1 - doc. Kushkevych nemá na WoS afiliaci na MU, nýbrž na Univer. veterinárního lékařství. Nelze přenášet do RIV bez domácího autora! KW - Sulfate-reducing bacteria KW - Desulfovibrio piger KW - Desulfomicrobium sp. KW - Salicylamides KW - Bowel disease KW - Lipophilicity KW - Structure–activity relationships UR - http://dx.doi.org/10.1016/j.jab.2016.01.005 L2 - http://dx.doi.org/10.1016/j.jab.2016.01.005 N2 - Sulfate-reducing bacteria (SRB) are most likely involved in both the initiation and maintenance of inflammatory bowel disease (IBD); unfortunately present antibacterial chemotherapeutics used in the treatment of IBD have been ineffective. Thus, the antimicrobial activity of salicylamide derivatives against two different genera of intestinal SRB, Desulfovibrio and Desulfomicrobium, was investigated. Six 2-(phenylcarbamoyl)phenyl N-[(benzyloxy)carbonyl]alkanoates and three 2-hydroxy-N-[(2S)-1-oxo-1-(phenylamino)alkan-2-yl]benzamides showed MIC values in the range from 0.22 to 0.35 microM against Desulfovibrio piger Vib-7 and in the range from 0.27 to 8.52 microM against Desulfomicrobium sp. Rod-9, while MIC values of ciprofloxacin were 41.2 microM and 39.3 microM. The highest potency against the two strains was observed for 4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-3-methyl-1-oxobutan-2-yl}-2-hydroxybenzamide (MIC 0.22 microM and 0.27 microM). 4-Chloro-2-[(4-nitrophenyl)carbamoyl]phenyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate showed high activity against D. piger Vib-7 (MIC = 0.26 microM), while 4-chloro-2-[(4-methylphenyl)carbamoyl]phenyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-(1H-indol-2-yl)propanoate expressed high activity against Desulfomicrobium sp. Rod-9 (MIC = 0.31 microM). Structure–activity relationships are discussed. ER -
KUSHKEVYCH, Ivan, Petr KOLLÁR, Ana Luísa FERREIRA a Diogo PALMA. Antimicrobial effect of salicylamide derivatives against intestinal sulfate-reducing bacteria. \textit{Journal of Applied Biomedicine}. 2016, roč.~2016, 14(2), s.~125-130. ISSN~1214-021X. Dostupné z: https://dx.doi.org/10.1016/j.jab.2016.01.005.
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