The meaning of sampling density in multiple repeat prostate
biopsies

J 2016

The meaning of sampling density in multiple repeat prostate biopsies

HRBÁČEK, Jan, Otakar ČAPOUN, Ivo MINÁRIK, Michal KÝR, Tomáš HANUŠ et. al.

Základní údaje

Originální název

The meaning of sampling density in multiple repeat prostate biopsies

Autoři

HRBÁČEK, Jan (203 Česká republika), Otakar ČAPOUN (203 Česká republika), Ivo MINÁRIK (203 Česká republika), Michal KÝR (203 Česká republika, garant, domácí), Tomáš HANUŠ (203 Česká republika), Marek BABJUK (203 Česká republika) a Roman SOBOTKA (203 Česká republika)

Vydání

Central European Journal of Urology, Warsaw, Panstwowy Zaklad Wydawnictw Lekarskich, 2016, 2080-4806

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/16:00094066

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.5173/ceju.2016.910

UT WoS

000392860500006

Klíčová slova anglicky

biopsy; cancer detection; prostate cancer

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 4. 2017 09:39, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Introduction Extended transrectal ultrasound-guided prostate biopsy is a state-of-the-art tool for prostate cancer detection. Nevertheless, approximately 1/3 of cancers are missed when using this method and repeat biopsy sessions are often required. The aim of this study was to investigate how sampling density (a compound variable reflecting the number of biopsy cores and prostate volume) impacts on detection rate in multiple repeat TRUS-biopsies. Material and methods A total of 1007 consecutive patients undergoing their 1st, 2nd, 3rd and any further repeat prostate biopsies were included. The relationship between sampling density and other clinical variables (age, prostate-specific antigen level, free/total PSA ratio, digital rectal examination, number of previous biopsies) and cancer detection rate were assessed by interaction analysis. Results There were 562 primary re-biopsies, 267 second re-biopsies and 178 third and further re-biopsies included in the study. Detection rate was 25.4%, 25.8% and 25.3%, respectively. Interaction of sampling density with age was demonstrated in patients undergoing their first repeat biopsy (but not further rebiopsies). No interaction was observed with other variables investigated. Conclusions A more extensive prostate sampling leads to a higher cancer detection rate on repeat prostate biopsies, as shown previously. However, this effect seems to be particularly pronounced in men younger than 65 years undergoing their first repeat prostate biopsy.

Citovat

HRBÁČEK, Jan, Otakar ČAPOUN, Ivo MINÁRIK, Michal KÝR, Tomáš HANUŠ, Marek BABJUK a Roman SOBOTKA. The meaning of sampling density in multiple repeat prostate biopsies. Central European Journal of Urology. Warsaw: Panstwowy Zaklad Wydawnictw Lekarskich, 2016, roč. 69, č. 4, s. 347-352. ISSN 2080-4806. Dostupné z: https://dx.doi.org/10.5173/ceju.2016.910.

@article{1377509,
   author = {Hrbáček, Jan and Čapoun, Otakar and Minárik, Ivo and Kýr, Michal and Hanuš, Tomáš and Babjuk, Marek and Sobotka, Roman},
   article_location = {Warsaw},
   article_number = {4},
   doi = {http://dx.doi.org/10.5173/ceju.2016.910},
   keywords = {biopsy; cancer detection; prostate cancer},
   language = {eng},
   issn = {2080-4806},
   journal = {Central European Journal of Urology},
   title = {The meaning of sampling density in multiple repeat prostate biopsies},
   volume = {69},
   year = {2016}
}

TY  - JOUR
ID  - 1377509
AU  - Hrbáček, Jan - Čapoun, Otakar - Minárik, Ivo - Kýr, Michal - Hanuš, Tomáš - Babjuk, Marek - Sobotka, Roman
PY  - 2016
TI  - The meaning of sampling density in multiple repeat prostate biopsies
JF  - Central European Journal of Urology
VL  - 69
IS  - 4
SP  - 347-352
EP  - 347-352
PB  - Panstwowy Zaklad Wydawnictw Lekarskich
SN  - 20804806
KW  - biopsy
KW  - cancer detection
KW  - prostate cancer
N2  - Introduction Extended transrectal ultrasound-guided prostate biopsy is a state-of-the-art tool for prostate cancer detection. Nevertheless, approximately 1/3 of cancers are missed when using this method and repeat biopsy sessions are often required. The aim of this study was to investigate how sampling density (a compound variable reflecting the number of biopsy cores and prostate volume) impacts on detection rate in multiple repeat TRUS-biopsies. Material and methods A total of 1007 consecutive patients undergoing their 1st, 2nd, 3rd and any further repeat prostate biopsies were included. The relationship between sampling density and other clinical variables (age, prostate-specific antigen level, free/total PSA ratio, digital rectal examination, number of previous biopsies) and cancer detection rate were assessed by interaction analysis. Results There were 562 primary re-biopsies, 267 second re-biopsies and 178 third and further re-biopsies included in the study. Detection rate was 25.4%, 25.8% and 25.3%, respectively. Interaction of sampling density with age was demonstrated in patients undergoing their first repeat biopsy (but not further rebiopsies). No interaction was observed with other variables investigated. Conclusions A more extensive prostate sampling leads to a higher cancer detection rate on repeat prostate biopsies, as shown previously. However, this effect seems to be particularly pronounced in men younger than 65 years undergoing their first repeat prostate biopsy.
ER  -

HRBÁČEK, Jan, Otakar ČAPOUN, Ivo MINÁRIK, Michal KÝR, Tomáš HANUŠ, Marek BABJUK a Roman SOBOTKA. The meaning of sampling density in multiple repeat prostate biopsies. \textit{Central European Journal of Urology}. Warsaw: Panstwowy Zaklad Wydawnictw Lekarskich, 2016, roč.~69, č.~4, s.~347-352. ISSN~2080-4806. Dostupné z: https://dx.doi.org/10.5173/ceju.2016.910.

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