Differential characteristics of ketamine self-administration in
the olfactory bulbectomy model of depression in male rats

J 2017

Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats

BABINSKÁ, Zuzana a Jana RUDÁ

Základní údaje

Originální název

Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats

Autoři

BABINSKÁ, Zuzana (703 Slovensko, domácí) a Jana RUDÁ (203 Česká republika, garant, domácí)

Vydání

Experimental and Clinical Psychopharmacology, Washington, American Psychological Association Inc. 2017, 1064-1297

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.354

Kód RIV

RIV/00216224:14110/17:00096469

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1037/pha0000106

UT WoS

000397860400004

Klíčová slova anglicky

Depression; Ketamine; Olfactory bulbectomy; Self-administration; Wistar rats

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 6. 2017 18:51, Soňa Böhmová

Anotace

V originále

Ketamine has been extensively studied for its antidepressant potential, with promising results in both preclinical and clinical studies. However, concerns regarding its abuse liabilities greatly limit its potential to become an approved treatment for depression. Therefore, a better understanding the risks and benefits of ketamine use in depression is needed. This study aimed to assess the characteristics of operant intravenous (IV) ketamine self-administration and relapse-like behavior in the olfactory bulbectomy (OBX) model of depression in male rats. Twenty-five male Wistar rats were divided randomly into 2 groups; in 1 group the bilateral olfactory bulbectomy was performed, whereas the other group was sham-operated. Intravenous self-administration of ketamine (.5 mg/kg/infusion) was conducted under a fixed ratio 1 schedule of reinforcement. After reaching stable drug intakes, rats then underwent a 14-day period of forced abstinence followed by a drug-free relapse-like session. The forced swim test was conducted before the commencement of the self-administration protocol and on the 1st day of abstinence. Consistent with findings in previous studies on other substances, OBX animals showed increased operant IV ketamine self-administration. In contrast, ketamine-seeking behavior in the OBX group did not differ from sham-operated animals during the relapse-like session, whereas previous studies on other psychostimulants like methamphetamine and cocaine reported increases. Our findings suggest substantially different underlying neuroadaptations between chronic ketamine and psychostimulant exposure.

Návaznosti

MUNI/A/1284/2015, interní kód MU

Název: Experimentální farmakologický vývoj v neuropsychiatrii a onkologii

Investor: Masarykova univerzita, Experimentální farmakologický vývoj v neuropsychiatrii a onkologii, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

ROZV/24/LF/2016, interní kód MU

Název: LF - Příspěvek IP 2016

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek IP 2016

Citovat

BABINSKÁ, Zuzana a Jana RUDÁ. Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats. Experimental and Clinical Psychopharmacology. Washington: American Psychological Association Inc., 2017, roč. 25, č. 2, s. 84-93. ISSN 1064-1297. Dostupné z: https://dx.doi.org/10.1037/pha0000106.

@article{1378142,
   author = {Babinská, Zuzana and Rudá, Jana},
   article_location = {Washington},
   article_number = {2},
   doi = {http://dx.doi.org/10.1037/pha0000106},
   keywords = {Depression; Ketamine; Olfactory bulbectomy; Self-administration; Wistar rats},
   language = {eng},
   issn = {1064-1297},
   journal = {Experimental and Clinical Psychopharmacology},
   title = {Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats},
   volume = {25},
   year = {2017}
}

TY  - JOUR
ID  - 1378142
AU  - Babinská, Zuzana - Rudá, Jana
PY  - 2017
TI  - Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats
JF  - Experimental and Clinical Psychopharmacology
VL  - 25
IS  - 2
SP  - 84-93
EP  - 84-93
PB  - American Psychological Association Inc.
SN  - 10641297
KW  - Depression
KW  - Ketamine
KW  - Olfactory bulbectomy
KW  - Self-administration
KW  - Wistar rats
N2  - Ketamine has been extensively studied for its antidepressant potential, with promising results in both preclinical and clinical studies. However, concerns regarding its abuse liabilities greatly limit its potential to become an approved treatment for depression. Therefore, a better understanding the risks and benefits of ketamine use in depression is needed. This study aimed to assess the characteristics of operant intravenous (IV) ketamine self-administration and relapse-like behavior in the olfactory bulbectomy (OBX) model of depression in male rats. Twenty-five male Wistar rats were divided randomly into 2 groups; in 1 group the bilateral olfactory bulbectomy was performed, whereas the other group was sham-operated. Intravenous self-administration of ketamine (.5 mg/kg/infusion) was conducted under a fixed ratio 1 schedule of reinforcement. After reaching stable drug intakes, rats then underwent a 14-day period of forced abstinence followed by a drug-free relapse-like session. The forced swim test was conducted before the commencement of the self-administration protocol and on the 1st day of abstinence. Consistent with findings in previous studies on other substances, OBX animals showed increased operant IV ketamine self-administration. In contrast, ketamine-seeking behavior in the OBX group did not differ from sham-operated animals during the relapse-like session, whereas previous studies on other psychostimulants like methamphetamine and cocaine reported increases. Our findings suggest substantially different underlying neuroadaptations between chronic ketamine and psychostimulant exposure.
ER  -

BABINSKÁ, Zuzana a Jana RUDÁ. Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats. \textit{Experimental and Clinical Psychopharmacology}. Washington: American Psychological Association Inc., 2017, roč.~25, č.~2, s.~84-93. ISSN~1064-1297. Dostupné z: https://dx.doi.org/10.1037/pha0000106.

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