True Nondisjunction of Whole Bivalents in Oocytes with
Attachment and Congression Defects

J 2017

True Nondisjunction of Whole Bivalents in Oocytes with Attachment and Congression Defects

ŠODEK, Martin, Kristína KOVAČOVICOVÁ a Martin ANGER

Základní údaje

Originální název

True Nondisjunction of Whole Bivalents in Oocytes with Attachment and Congression Defects

Autoři

ŠODEK, Martin (203 Česká republika, domácí), Kristína KOVAČOVICOVÁ (703 Slovensko, domácí) a Martin ANGER (203 Česká republika, garant, domácí)

Vydání

Cytogenetic and Genome research, Basel, Karger, 2017, 1424-8581

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.587

Kód RIV

RIV/00216224:14110/17:00094711

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1159/000458513

UT WoS

000399694600003

Klíčová slova anglicky

Aneuploidy; Bivalents; Chromosome congression; Chromosome segregation; Meiosis; Nondisjunction; Oocyte

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 3. 2018 16:41, Soňa Böhmová

Anotace

V originále

Chromosome segregation in mammalian oocytes is prone to errors causing aneuploidy with consequences such as precocious termination of development or severe developmental disorders. Aneuploidy also represents a serious problem in procedures utilizing mammalian gametes and early embryos in vitro. In our study, we focused on congression defects during meiosis I and observed whole nondisjoined bivalents in meiosis II as a direct consequence, together with a substantially delayed first polar body extrusion. We also show that the congression defects are accompanied by less stable attachments of the kinetochores. Our results describe a process by which congression defects directly contribute to aneuploidy. (C) 2017 S. Karger AG, Basel

Návaznosti

GA15-04844S, projekt VaV

Název: Osud aneuploidních buněk ve vyvíjejícím se embryu a populaci kmenových buněk

Investor: Grantová agentura ČR, Osud aneuploidních buněk ve vyvíjejícím se embryu a populaci kmenových buněk

LM2015062, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

ŠODEK, Martin, Kristína KOVAČOVICOVÁ a Martin ANGER. True Nondisjunction of Whole Bivalents in Oocytes with Attachment and Congression Defects. Cytogenetic and Genome research. Basel: Karger, 2017, roč. 151, č. 1, s. 10-17. ISSN 1424-8581. Dostupné z: https://dx.doi.org/10.1159/000458513.

@article{1378163,
   author = {Šodek, Martin and Kovačovicová, Kristína and Anger, Martin},
   article_location = {Basel},
   article_number = {1},
   doi = {http://dx.doi.org/10.1159/000458513},
   keywords = {Aneuploidy; Bivalents; Chromosome congression; Chromosome segregation; Meiosis; Nondisjunction; Oocyte},
   language = {eng},
   issn = {1424-8581},
   journal = {Cytogenetic and Genome research},
   title = {True Nondisjunction of Whole Bivalents in Oocytes with Attachment and Congression Defects},
   volume = {151},
   year = {2017}
}

TY  - JOUR
ID  - 1378163
AU  - Šodek, Martin - Kovačovicová, Kristína - Anger, Martin
PY  - 2017
TI  - True Nondisjunction of Whole Bivalents in Oocytes with Attachment and Congression Defects
JF  - Cytogenetic and Genome research
VL  - 151
IS  - 1
SP  - 10-17
EP  - 10-17
PB  - Karger
SN  - 14248581
KW  - Aneuploidy
KW  - Bivalents
KW  - Chromosome congression
KW  - Chromosome segregation
KW  - Meiosis
KW  - Nondisjunction
KW  - Oocyte
N2  - Chromosome segregation in mammalian oocytes is prone to errors causing aneuploidy with consequences such as precocious termination of development or severe developmental disorders. Aneuploidy also represents a serious problem in procedures utilizing mammalian gametes and early embryos in vitro. In our study, we focused on congression defects during meiosis I and observed whole nondisjoined bivalents in meiosis II as a direct consequence, together with a substantially delayed first polar body extrusion. We also show that the congression defects are accompanied by less stable attachments of the kinetochores. Our results describe a process by which congression defects directly contribute to aneuploidy. (C) 2017 S. Karger AG, Basel
ER  -

ŠODEK, Martin, Kristína KOVAČOVICOVÁ a Martin ANGER. True Nondisjunction of Whole Bivalents in Oocytes with Attachment and Congression Defects. \textit{Cytogenetic and Genome research}. Basel: Karger, 2017, roč.~151, č.~1, s.~10-17. ISSN~1424-8581. Dostupné z: https://dx.doi.org/10.1159/000458513.

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