NARDONE, Giorgia, Jorge Oliver-De La CRUZ, Jan VRBSKÝ, Cecilia MARTINI, Jan PŘIBYL, Petr SKLÁDAL, Martin PEŠL, Guido CALUORI, Stefania PAGLIARI, Fabiana MARTINO, Zuzana MACECKOVA, Marian HAJDÚCH, Andres SANZ-GARCIA, Nicola Maria PUGNO, Gorazd Bernard STOKIN a Giancarlo FORTE. YAP regulates cell mechanics by controlling focaladhesion assembly. NATURE COMMUNICATIONS. London: Nature Publishing Group, 2017, roč. 8, č. 15321, s. 1-13. ISSN 2041-1723. Dostupné z: https://dx.doi.org/10.1038/ncomms15321. |
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@article{1380781, author = {Nardone, Giorgia and Cruz, Jorge OliverandDe La and Vrbský, Jan and Martini, Cecilia and Přibyl, Jan and Skládal, Petr and Pešl, Martin and Caluori, Guido and Pagliari, Stefania and Martino, Fabiana and Maceckova, Zuzana and Hajdúch, Marian and SanzandGarcia, Andres and Pugno, Nicola Maria and Stokin, Gorazd Bernard and Forte, Giancarlo}, article_location = {London}, article_number = {15321}, doi = {http://dx.doi.org/10.1038/ncomms15321}, keywords = {Hippo effectors YAP/TAZ; mechanosensing; extracellular matrix; focal adhesions; RhoA GTPase activity; actin cytoskeleton}, language = {eng}, issn = {2041-1723}, journal = {NATURE COMMUNICATIONS}, title = {YAP regulates cell mechanics by controlling focaladhesion assembly}, url = {https://www.nature.com/articles/ncomms15321}, volume = {8}, year = {2017} }
TY - JOUR ID - 1380781 AU - Nardone, Giorgia - Cruz, Jorge Oliver-De La - Vrbský, Jan - Martini, Cecilia - Přibyl, Jan - Skládal, Petr - Pešl, Martin - Caluori, Guido - Pagliari, Stefania - Martino, Fabiana - Maceckova, Zuzana - Hajdúch, Marian - Sanz-Garcia, Andres - Pugno, Nicola Maria - Stokin, Gorazd Bernard - Forte, Giancarlo PY - 2017 TI - YAP regulates cell mechanics by controlling focaladhesion assembly JF - NATURE COMMUNICATIONS VL - 8 IS - 15321 SP - 1-13 EP - 1-13 PB - Nature Publishing Group SN - 20411723 KW - Hippo effectors YAP/TAZ KW - mechanosensing KW - extracellular matrix KW - focal adhesions KW - RhoA GTPase activity KW - actin cytoskeleton UR - https://www.nature.com/articles/ncomms15321 L2 - https://www.nature.com/articles/ncomms15321 N2 - Hippo effectors YAP/TAZ act as on–off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway are under the control of focal adhesions (FAs). Here we unveil the molecular mechanism by which cell spreading and RhoA GTPase activity control FA formation through YAP to stabilize the anchorage of the actin cytoskeleton to the cell membrane. This mechanism requires YAP co-transcriptional function and involves the activation of genes encoding for integrins and FA docking proteins. Tuning YAP transcriptional activity leads to the modification of cell mechanics, force development and adhesion strength, and determines cell shape, migration and differentiation. These results provide new insights into the mechanism of YAP mechanosensing activity and qualify this Hippo effector as the key determinant of cell mechanics in response to ECM cues. ER -
NARDONE, Giorgia, Jorge Oliver-De La CRUZ, Jan VRBSKÝ, Cecilia MARTINI, Jan PŘIBYL, Petr SKLÁDAL, Martin PEŠL, Guido CALUORI, Stefania PAGLIARI, Fabiana MARTINO, Zuzana MACECKOVA, Marian HAJDÚCH, Andres SANZ-GARCIA, Nicola Maria PUGNO, Gorazd Bernard STOKIN a Giancarlo FORTE. YAP regulates cell mechanics by controlling focaladhesion assembly. \textit{NATURE COMMUNICATIONS}. London: Nature Publishing Group, 2017, roč.~8, č.~15321, s.~1-13. ISSN~2041-1723. Dostupné z: https://dx.doi.org/10.1038/ncomms15321.
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