Association study of interleukin-1 family, interleukin-6, and
its receptor gene polymorphisms in patients with recurrent
aphthous stomatitis

J 2017

Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis

IZAKOVIČOVÁ HOLLÁ, Lydie; Simona VALOVÁ; Petra BOŘILOVÁ LINHARTOVÁ; Jiřina BÁRTOVÁ; Jitka PETANOVÁ et. al.

Základní údaje

Originální název

Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis

Autoři

IZAKOVIČOVÁ HOLLÁ, Lydie (203 Česká republika, garant, domácí); Simona VALOVÁ (203 Česká republika, domácí); Petra BOŘILOVÁ LINHARTOVÁ (203 Česká republika, domácí); Jiřina BÁRTOVÁ (203 Česká republika); Jitka PETANOVÁ (203 Česká republika); Pavel KUKLÍNEK (203 Česká republika, domácí) a Antonín FASSMANN (203 Česká republika, domácí)

Vydání

Journal of Oral Pathology & Medicine, Hoboken, Wiley, 2017, 0904-2512

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.237

Kód RIV

RIV/00216224:14110/17:00095638

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1111/jop.12594

UT WoS

000414366000027

EID Scopus

2-s2.0-85020485496

Klíčová slova anglicky

IL-1; IL-6; gene polymorphism; aphthous stomatitis; case-control study

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 2. 2018 16:45, Soňa Böhmová

Anotace

V originále

Background Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin 1 (IL-1) and interleukin 6 (IL-6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL-1 cytokine family, IL-6 or its receptor and RAS in the Czech population. Methods A total of 248 subjects, 184 healthy controls and 64 patients with RAS were genotyped for IL-1A-889C>T, IL-1B-511C>T, IL-1B+3953C>T, IL-1RN86 bp variable number of tandem repeats (VNTR) in intron 2, IL-6-597G>A, IL-6-572G>C, IL-6-174G>C and IL-6R+48992A>C by polymerase chain reaction (PCR) methods. Results No significant differences between investigated polymorphisms in healthy subjects and patients with RAS were detected (P>0.05). In addition, complex analysis also revealed similar IL-1 or IL-6 haplotype frequencies between both groups (P>0.05). Conclusions In conclusion, IL-1 and IL-6 or its receptor gene variants cannot be used as markers for identification of Czech patients with increased risk of recurrent aphthous stomatitis.

Návaznosti

NV15-29336A, projekt VaV

Název: Změny imunologické reaktivity u pacientů s recidivujícími aftami

Citovat

IZAKOVIČOVÁ HOLLÁ, Lydie; Simona VALOVÁ; Petra BOŘILOVÁ LINHARTOVÁ; Jiřina BÁRTOVÁ; Jitka PETANOVÁ; Pavel KUKLÍNEK a Antonín FASSMANN. Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. Hoboken: Wiley, 2017, roč. 46, č. 10, s. 1030-1035. ISSN 0904-2512. Dostupné z: https://doi.org/10.1111/jop.12594.

@article{1381311,
   author = {Izakovičová Hollá, Lydie and Valová, Simona and Bořilová Linhartová, Petra and Bártová, Jiřina and Petanová, Jitka and Kuklínek, Pavel and Fassmann, Antonín},
   article_location = {Hoboken},
   article_number = {10},
   doi = {https://doi.org/10.1111/jop.12594},
   keywords = {IL-1; IL-6; gene polymorphism; aphthous stomatitis; case-control study},
   language = {eng},
   issn = {0904-2512},
   journal = {Journal of Oral Pathology & Medicine},
   title = {Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis},
   volume = {46},
   year = {2017}
}

TY  - JOUR
ID  - 1381311
AU  - Izakovičová Hollá, Lydie - Valová, Simona - Bořilová Linhartová, Petra - Bártová, Jiřina - Petanová, Jitka - Kuklínek, Pavel - Fassmann, Antonín
PY  - 2017
TI  - Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis
JF  - Journal of Oral Pathology & Medicine
VL  - 46
IS  - 10
SP  - 1030-1035
EP  - 1030-1035
PB  - Wiley
SN  - 09042512
KW  - IL-1
KW  - IL-6
KW  - gene polymorphism
KW  - aphthous stomatitis
KW  - case-control study
N2  - Background Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin 1 (IL-1) and interleukin 6 (IL-6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL-1 cytokine family, IL-6 or its receptor and RAS in the Czech population. Methods A total of 248 subjects, 184 healthy controls and 64 patients with RAS were genotyped for IL-1A-889C>T, IL-1B-511C>T, IL-1B+3953C>T, IL-1RN86 bp variable number of tandem repeats (VNTR) in intron 2, IL-6-597G>A, IL-6-572G>C, IL-6-174G>C and IL-6R+48992A>C by polymerase chain reaction (PCR) methods. Results No significant differences between investigated polymorphisms in healthy subjects and patients with RAS were detected (P>0.05). In addition, complex analysis also revealed similar IL-1 or IL-6 haplotype frequencies between both groups (P>0.05). Conclusions In conclusion, IL-1 and IL-6 or its receptor gene variants cannot be used as markers for identification of Czech patients with increased risk of recurrent aphthous stomatitis.
ER  -

IZAKOVIČOVÁ HOLLÁ, Lydie; Simona VALOVÁ; Petra BOŘILOVÁ LINHARTOVÁ; Jiřina BÁRTOVÁ; Jitka PETANOVÁ; Pavel KUKLÍNEK a Antonín FASSMANN. Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis. \textit{Journal of Oral Pathology \&{} Medicine}. Hoboken: Wiley, 2017, roč.~46, č.~10, s.~1030-1035. ISSN~0904-2512. Dostupné z: https://doi.org/10.1111/jop.12594.

Přehled o publikaci