Association study of interleukin-1 family, interleukin-6, and
its receptor gene polymorphisms in patients with recurrent
aphthous stomatitis

J 2017

Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis

IZAKOVIČOVÁ HOLLÁ, Lydie, Simona VALOVÁ, Petra BOŘILOVÁ LINHARTOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ et. al.

Základní údaje

Originální název

Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis

Autoři

IZAKOVIČOVÁ HOLLÁ, Lydie (203 Česká republika, garant, domácí), Simona VALOVÁ (203 Česká republika, domácí), Petra BOŘILOVÁ LINHARTOVÁ (203 Česká republika, domácí), Jiřina BÁRTOVÁ (203 Česká republika), Jitka PETANOVÁ (203 Česká republika), Pavel KUKLÍNEK (203 Česká republika, domácí) a Antonín FASSMANN (203 Česká republika, domácí)

Vydání

Journal of Oral Pathology & Medicine, Hoboken, Wiley, 2017, 0904-2512

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.237

Kód RIV

RIV/00216224:14110/17:00095638

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/jop.12594

UT WoS

000414366000027

Klíčová slova anglicky

IL-1; IL-6; gene polymorphism; aphthous stomatitis; case-control study

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 2. 2018 16:45, Soňa Böhmová

Anotace

V originále

Background Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin 1 (IL-1) and interleukin 6 (IL-6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL-1 cytokine family, IL-6 or its receptor and RAS in the Czech population. Methods A total of 248 subjects, 184 healthy controls and 64 patients with RAS were genotyped for IL-1A-889C>T, IL-1B-511C>T, IL-1B+3953C>T, IL-1RN86 bp variable number of tandem repeats (VNTR) in intron 2, IL-6-597G>A, IL-6-572G>C, IL-6-174G>C and IL-6R+48992A>C by polymerase chain reaction (PCR) methods. Results No significant differences between investigated polymorphisms in healthy subjects and patients with RAS were detected (P>0.05). In addition, complex analysis also revealed similar IL-1 or IL-6 haplotype frequencies between both groups (P>0.05). Conclusions In conclusion, IL-1 and IL-6 or its receptor gene variants cannot be used as markers for identification of Czech patients with increased risk of recurrent aphthous stomatitis.

Návaznosti

NV15-29336A, projekt VaV

Název: Změny imunologické reaktivity u pacientů s recidivujícími aftami

Citovat

IZAKOVIČOVÁ HOLLÁ, Lydie, Simona VALOVÁ, Petra BOŘILOVÁ LINHARTOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ, Pavel KUKLÍNEK a Antonín FASSMANN. Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. Hoboken: Wiley, 2017, roč. 46, č. 10, s. 1030-1035. ISSN 0904-2512. Dostupné z: https://dx.doi.org/10.1111/jop.12594.

@article{1381311,
   author = {Izakovičová Hollá, Lydie and Valová, Simona and Bořilová Linhartová, Petra and Bártová, Jiřina and Petanová, Jitka and Kuklínek, Pavel and Fassmann, Antonín},
   article_location = {Hoboken},
   article_number = {10},
   doi = {http://dx.doi.org/10.1111/jop.12594},
   keywords = {IL-1; IL-6; gene polymorphism; aphthous stomatitis; case-control study},
   language = {eng},
   issn = {0904-2512},
   journal = {Journal of Oral Pathology & Medicine},
   title = {Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis},
   volume = {46},
   year = {2017}
}

TY  - JOUR
ID  - 1381311
AU  - Izakovičová Hollá, Lydie - Valová, Simona - Bořilová Linhartová, Petra - Bártová, Jiřina - Petanová, Jitka - Kuklínek, Pavel - Fassmann, Antonín
PY  - 2017
TI  - Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis
JF  - Journal of Oral Pathology & Medicine
VL  - 46
IS  - 10
SP  - 1030-1035
EP  - 1030-1035
PB  - Wiley
SN  - 09042512
KW  - IL-1
KW  - IL-6
KW  - gene polymorphism
KW  - aphthous stomatitis
KW  - case-control study
N2  - Background Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin 1 (IL-1) and interleukin 6 (IL-6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL-1 cytokine family, IL-6 or its receptor and RAS in the Czech population. Methods A total of 248 subjects, 184 healthy controls and 64 patients with RAS were genotyped for IL-1A-889C>T, IL-1B-511C>T, IL-1B+3953C>T, IL-1RN86 bp variable number of tandem repeats (VNTR) in intron 2, IL-6-597G>A, IL-6-572G>C, IL-6-174G>C and IL-6R+48992A>C by polymerase chain reaction (PCR) methods. Results No significant differences between investigated polymorphisms in healthy subjects and patients with RAS were detected (P>0.05). In addition, complex analysis also revealed similar IL-1 or IL-6 haplotype frequencies between both groups (P>0.05). Conclusions In conclusion, IL-1 and IL-6 or its receptor gene variants cannot be used as markers for identification of Czech patients with increased risk of recurrent aphthous stomatitis.
ER  -

IZAKOVIČOVÁ HOLLÁ, Lydie, Simona VALOVÁ, Petra BOŘILOVÁ LINHARTOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ, Pavel KUKLÍNEK a Antonín FASSMANN. Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis. \textit{Journal of Oral Pathology \&{} Medicine}. Hoboken: Wiley, 2017, roč.~46, č.~10, s.~1030-1035. ISSN~0904-2512. Dostupné z: https://dx.doi.org/10.1111/jop.12594.

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