Detailed Information on Publication Record
2017
Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis
IZAKOVIČOVÁ HOLLÁ, Lydie, Simona VALOVÁ, Petra BOŘILOVÁ LINHARTOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ et. al.Basic information
Original name
Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis
Authors
IZAKOVIČOVÁ HOLLÁ, Lydie (203 Czech Republic, guarantor, belonging to the institution), Simona VALOVÁ (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Jiřina BÁRTOVÁ (203 Czech Republic), Jitka PETANOVÁ (203 Czech Republic), Pavel KUKLÍNEK (203 Czech Republic, belonging to the institution) and Antonín FASSMANN (203 Czech Republic, belonging to the institution)
Edition
Journal of Oral Pathology & Medicine, Hoboken, Wiley, 2017, 0904-2512
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30208 Dentistry, oral surgery and medicine
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.237
RIV identification code
RIV/00216224:14110/17:00095638
Organization unit
Faculty of Medicine
UT WoS
000414366000027
Keywords in English
IL-1; IL-6; gene polymorphism; aphthous stomatitis; case-control study
Tags
Tags
International impact, Reviewed
Změněno: 28/2/2018 16:45, Soňa Böhmová
Abstract
V originále
Background Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin 1 (IL-1) and interleukin 6 (IL-6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL-1 cytokine family, IL-6 or its receptor and RAS in the Czech population. Methods A total of 248 subjects, 184 healthy controls and 64 patients with RAS were genotyped for IL-1A-889C>T, IL-1B-511C>T, IL-1B+3953C>T, IL-1RN86 bp variable number of tandem repeats (VNTR) in intron 2, IL-6-597G>A, IL-6-572G>C, IL-6-174G>C and IL-6R+48992A>C by polymerase chain reaction (PCR) methods. Results No significant differences between investigated polymorphisms in healthy subjects and patients with RAS were detected (P>0.05). In addition, complex analysis also revealed similar IL-1 or IL-6 haplotype frequencies between both groups (P>0.05). Conclusions In conclusion, IL-1 and IL-6 or its receptor gene variants cannot be used as markers for identification of Czech patients with increased risk of recurrent aphthous stomatitis.
Links
| NV15-29336A, research and development project |
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