Infectious complications and immune/inflammatory response in
cardiogenic shock patients: A prospective observational study

J 2017

Infectious complications and immune/inflammatory response in cardiogenic shock patients: A prospective observational study

PAŘENICA, Jiří, Jiří JARKOVSKÝ, Jan MALÁSKA, Alexandre MEBAZAA, Jana GOTTWALDOVÁ et. al.

Základní údaje

Originální název

Infectious complications and immune/inflammatory response in cardiogenic shock patients: A prospective observational study

Autoři

PAŘENICA, Jiří (203 Česká republika, garant, domácí), Jiří JARKOVSKÝ (203 Česká republika, domácí), Jan MALÁSKA (203 Česká republika, domácí), Alexandre MEBAZAA (250 Francie), Jana GOTTWALDOVÁ (203 Česká republika, domácí), Kateřina HELÁNOVÁ (203 Česká republika), Jiří LITZMAN (203 Česká republika, domácí), Milan DASTYCH (203 Česká republika, domácí), Josef TOMANDL (203 Česká republika, domácí), Jindřich ŠPINAR (203 Česká republika, domácí), Ludmila DOSTÁLOVÁ (203 Česká republika, domácí), Petr LOKAJ (203 Česká republika, domácí), Marie TOMANDLOVÁ (203 Česká republika, domácí), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Česká republika, domácí), Pavel ŠEVČÍK (203 Česká republika) a Matthieu LEGRAND (250 Francie)

Vydání

Shock, Philadelphia, Lippincott Williams & Wilkins, 2017, 1073-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.005

Kód RIV

RIV/00216224:14110/17:00096765

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1097/SHK.0000000000000756

UT WoS

000392813300007

Klíčová slova anglicky

Cardiogenic shock; C-reactive protein; infection; inflammatory response; pentraxin 3; presepsin; procalcitonin

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 3. 2018 14:25, Soňa Böhmová

Anotace

V originále

Introduction: Patients with cardiogenic shock (CS) are at a high risk of developing infectious complications; however, their early detection is difficult, mainly due to a frequently occurring noninfectious inflammatory response, which accompanies an extensivemyocardial infarction (MI) or a postcardiac arrest syndrome. The goal of our prospective study was to describe infectious complications in CS and the immune/inflammatory response based on a serial measurement of several blood-based inflammatory biomarkers. Methods: Eighty patients with CS were evaluated and their infections were monitored. Inflammatory markers (C-reactive protein, procalcitonin, pentraxin 3, presepsin) were measured seven times per week. The control groups consisted of 11 patients with ST segment elevation myocardial infarction without CS and without infection, and 22 patients in septic shock. Results: Infection was diagnosed in 46.3% of patients with CS; 16 patients developed an infection within 48 h. Respiratory infection was most common, occurring in 33 out of 37 patients. Infection was a significant or even the main reason of death only in 3.8% of all patients with CS, and we did not find statistically significant difference in 3-month mortality between group of patients with CS with and without infection. There was no statistically significant prolongation of the duration of mechanical ventilation associated with infection. Strong inflammatory response is often in patientswith CS due to MI, but we found no significant difference in the course of the inflammatory response expressed by evaluated biomarkers in patients with CS with and without infection. We found a strong relationship between the elevated inflammatory markers (sampled at 12 h) and the 3-month mortality: the area under the curve of receiver operating characteristic ranged between 0.683 and 0.875. Conclusion: The prevalence of infection in patients with CS was 46.3%, and respiratory tract infections were the most common type. Infections did not prolong statistically significantly the duration of mechanical ventilation and did not increase the prevalence of hospital mortality in this high-risk CS population. CS due to acute myocardial infarction was accompanied by a strong and highly variable inflammatory response, but it did not reach the intensity of the inflammatory response observed in patients with septic shock. An extensive immune/inflammatory response in patients with CS is linked to a poor prognosis.

Návaznosti

MUNI/A/1362/2015, interní kód MU

Název: Neurohumorální profil a prognóza pacientů s chronickým srdečním selháním

Investor: Masarykova univerzita, Neurohumorální profil a prognóza pacientů s chronickým srdečním selháním, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

PAŘENICA, Jiří, Jiří JARKOVSKÝ, Jan MALÁSKA, Alexandre MEBAZAA, Jana GOTTWALDOVÁ, Kateřina HELÁNOVÁ, Jiří LITZMAN, Milan DASTYCH, Josef TOMANDL, Jindřich ŠPINAR, Ludmila DOSTÁLOVÁ, Petr LOKAJ, Marie TOMANDLOVÁ, Monika PÁVKOVÁ GOLDBERGOVÁ, Pavel ŠEVČÍK a Matthieu LEGRAND. Infectious complications and immune/inflammatory response in cardiogenic shock patients: A prospective observational study. Shock. Philadelphia: Lippincott Williams & Wilkins, 2017, roč. 47, č. 2, s. 165-174. ISSN 1073-2322. Dostupné z: https://dx.doi.org/10.1097/SHK.0000000000000756.

@article{1381316,
   author = {Pařenica, Jiří and Jarkovský, Jiří and Maláska, Jan and Mebazaa, Alexandre and Gottwaldová, Jana and Helánová, Kateřina and Litzman, Jiří and Dastych, Milan and Tomandl, Josef and Špinar, Jindřich and Dostálová, Ludmila and Lokaj, Petr and Tomandlová, Marie and Pávková Goldbergová, Monika and Ševčík, Pavel and Legrand, Matthieu},
   article_location = {Philadelphia},
   article_number = {2},
   doi = {http://dx.doi.org/10.1097/SHK.0000000000000756},
   keywords = {Cardiogenic shock; C-reactive protein; infection; inflammatory response; pentraxin 3; presepsin; procalcitonin},
   language = {eng},
   issn = {1073-2322},
   journal = {Shock},
   title = {Infectious complications and immune/inflammatory response in cardiogenic shock patients: A prospective observational study},
   volume = {47},
   year = {2017}
}

TY  - JOUR
ID  - 1381316
AU  - Pařenica, Jiří - Jarkovský, Jiří - Maláska, Jan - Mebazaa, Alexandre - Gottwaldová, Jana - Helánová, Kateřina - Litzman, Jiří - Dastych, Milan - Tomandl, Josef - Špinar, Jindřich - Dostálová, Ludmila - Lokaj, Petr - Tomandlová, Marie - Pávková Goldbergová, Monika - Ševčík, Pavel - Legrand, Matthieu
PY  - 2017
TI  - Infectious complications and immune/inflammatory response in cardiogenic shock patients: A prospective observational study
JF  - Shock
VL  - 47
IS  - 2
SP  - 165-174
EP  - 165-174
PB  - Lippincott Williams & Wilkins
SN  - 10732322
KW  - Cardiogenic shock
KW  - C-reactive protein
KW  - infection
KW  - inflammatory response
KW  - pentraxin 3
KW  - presepsin
KW  - procalcitonin
N2  - Introduction: Patients with cardiogenic shock (CS) are at a high risk of developing infectious complications; however, their early detection is difficult, mainly due to a frequently occurring noninfectious inflammatory response, which accompanies an extensivemyocardial infarction (MI) or a postcardiac arrest syndrome. The goal of our prospective study was to describe infectious complications in CS and the immune/inflammatory response based on a serial measurement of several blood-based inflammatory biomarkers. Methods: Eighty patients with CS were evaluated and their infections were monitored. Inflammatory markers (C-reactive protein, procalcitonin, pentraxin 3, presepsin) were measured seven times per week. The control groups consisted of 11 patients with ST segment elevation myocardial infarction without CS and without infection, and 22 patients in septic shock. Results: Infection was diagnosed in 46.3% of patients with CS; 16 patients developed an infection within 48 h. Respiratory infection was most common, occurring in 33 out of 37 patients. Infection was a significant or even the main reason of death only in 3.8% of all patients with CS, and we did not find statistically significant difference in 3-month mortality between group of patients with CS with and without infection. There was no statistically significant prolongation of the duration of mechanical ventilation associated with infection. Strong inflammatory response is often in patientswith CS due to MI, but we found no significant difference in the course of the inflammatory response expressed by evaluated biomarkers in patients with CS with and without infection. We found a strong relationship between the elevated inflammatory markers (sampled at 12 h) and the 3-month mortality: the area under the curve of receiver operating characteristic ranged between 0.683 and 0.875. Conclusion: The prevalence of infection in patients with CS was 46.3%, and respiratory tract infections were the most common type. Infections did not prolong statistically significantly the duration of mechanical ventilation and did not increase the prevalence of hospital mortality in this high-risk CS population. CS due to acute myocardial infarction was accompanied by a strong and highly variable inflammatory response, but it did not reach the intensity of the inflammatory response observed in patients with septic shock. An extensive immune/inflammatory response in patients with CS is linked to a poor prognosis.
ER  -

PAŘENICA, Jiří, Jiří JARKOVSKÝ, Jan MALÁSKA, Alexandre MEBAZAA, Jana GOTTWALDOVÁ, Kateřina HELÁNOVÁ, Jiří LITZMAN, Milan DASTYCH, Josef TOMANDL, Jindřich ŠPINAR, Ludmila DOSTÁLOVÁ, Petr LOKAJ, Marie TOMANDLOVÁ, Monika PÁVKOVÁ GOLDBERGOVÁ, Pavel ŠEVČÍK a Matthieu LEGRAND. Infectious complications and immune/inflammatory response in cardiogenic shock patients: A prospective observational study. \textit{Shock}. Philadelphia: Lippincott Williams \&{} Wilkins, 2017, roč.~47, č.~2, s.~165-174. ISSN~1073-2322. Dostupné z: https://dx.doi.org/10.1097/SHK.0000000000000756.

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