Relationship of long-term prognosis to MMP and TIMP
polymorphisms in patients after ST elevation myocardial
infarction

J 2017

Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction

PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří JARKOVSKÝ, Jolana LIPKOVÁ, Simona LITTNEROVÁ, Martin POLOCZEK et. al.

Základní údaje

Originální název

Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction

Autoři

PÁVKOVÁ GOLDBERGOVÁ, Monika (203 Česká republika, garant, domácí), Jiří JARKOVSKÝ (203 Česká republika, domácí), Jolana LIPKOVÁ (203 Česká republika, domácí), Simona LITTNEROVÁ (203 Česká republika, domácí), Martin POLOCZEK (203 Česká republika, domácí), Jindřich ŠPINAR (203 Česká republika, domácí), Lenka KUBKOVÁ (203 Česká republika, domácí), Krystyna KLUZ (203 Česká republika, domácí), Petr KALA (203 Česká republika, domácí), Jan MAŇOUŠEK (203 Česká republika, domácí), Anna VAŠKŮ (203 Česká republika, domácí) a Jiří PAŘENICA (203 Česká republika, domácí)

Vydání

Journal of Applied Genetics, Heidelberg, Springer, 2017, 1234-1983

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30400 3.4 Medical biotechnology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.756

Kód RIV

RIV/00216224:14110/17:00096767

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s13353-016-0388-8

UT WoS

000405693600005

Klíčová slova anglicky

MMP; Polymorphism; Prognosis; STEMI; TIMP

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 2. 2021 15:04, Mgr. Tereza Miškechová

Anotace

V originále

The influence of polymorphisms in the large group of MMP and TIMP genes on clinical outcomes in patients after ST elevation myocardial infarction (STEMI) treated with primary PCI was analysed. In total, 550 consecutive Caucasian patients with STEMI were included in the present study, with a median of 32 months. We analysed 19 polymorphisms in the genes coding MMP and TIMP genes. The MMP-1 -519A/G and -422A/T polymorphisms are associated with combined endpoint after myocardial infarction. The hazard ratio for AT variant of MMP-1 -422A/T was 1.75 (p < 0.001); the variants with at least one A allele of MMP-1 -519A/G have less risk of combined endpoint. The TT variants of -1562C/T MMP-9 and at least one T allele of +92C/T MMP-13 were considered in a trend to affect disease progression and long-term survival after myocardial infarction. According to reclassification analysis NRI and IDI, long-term risk stratification using MMP-1 -422A/T and -519A/G polymorphisms gives additional information to the commonly used GRACE risk score. Patient stratification after myocardial infraction (MI) according to risk genotypes of MMP-1 polymorphisms could have important clinical implications for identification of patients at risk and therapeutic strategies.

Návaznosti

LM2015090, projekt VaV

Název: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Akronym: CZECRIN)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CZECRIN - Český národní uzel Evropské sítě infrastruktur klinického výzkumu

Citovat

PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří JARKOVSKÝ, Jolana LIPKOVÁ, Simona LITTNEROVÁ, Martin POLOCZEK, Jindřich ŠPINAR, Lenka KUBKOVÁ, Krystyna KLUZ, Petr KALA, Jan MAŇOUŠEK, Anna VAŠKŮ a Jiří PAŘENICA. Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction. Journal of Applied Genetics. Heidelberg: Springer, 2017, roč. 58, č. 3, s. 331-341. ISSN 1234-1983. Dostupné z: https://dx.doi.org/10.1007/s13353-016-0388-8.

@article{1381321,
   author = {Pávková Goldbergová, Monika and Jarkovský, Jiří and Lipková, Jolana and Littnerová, Simona and Poloczek, Martin and Špinar, Jindřich and Kubková, Lenka and Kluz, Krystyna and Kala, Petr and Maňoušek, Jan and Vašků, Anna and Pařenica, Jiří},
   article_location = {Heidelberg},
   article_number = {3},
   doi = {http://dx.doi.org/10.1007/s13353-016-0388-8},
   keywords = {MMP; Polymorphism; Prognosis; STEMI; TIMP},
   language = {eng},
   issn = {1234-1983},
   journal = {Journal of Applied Genetics},
   title = {Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction},
   url = {http://dx.doi.org/10.1007/s13353-016-0388-8},
   volume = {58},
   year = {2017}
}

TY  - JOUR
ID  - 1381321
AU  - Pávková Goldbergová, Monika - Jarkovský, Jiří - Lipková, Jolana - Littnerová, Simona - Poloczek, Martin - Špinar, Jindřich - Kubková, Lenka - Kluz, Krystyna - Kala, Petr - Maňoušek, Jan - Vašků, Anna - Pařenica, Jiří
PY  - 2017
TI  - Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction
JF  - Journal of Applied Genetics
VL  - 58
IS  - 3
SP  - 331-341
EP  - 331-341
PB  - Springer
SN  - 12341983
KW  - MMP
KW  - Polymorphism
KW  - Prognosis
KW  - STEMI
KW  - TIMP
UR  - http://dx.doi.org/10.1007/s13353-016-0388-8
L2  - http://dx.doi.org/10.1007/s13353-016-0388-8
N2  - The influence of polymorphisms in the large group of MMP and TIMP genes on clinical outcomes in patients after ST elevation myocardial infarction (STEMI) treated with primary PCI was analysed. In total, 550 consecutive Caucasian patients with STEMI were included in the present study, with a median of 32 months. We analysed 19 polymorphisms in the genes coding MMP and TIMP genes. The MMP-1 -519A/G and -422A/T polymorphisms are associated with combined endpoint after myocardial infarction. The hazard ratio for AT variant of MMP-1 -422A/T was 1.75 (p < 0.001); the variants with at least one A allele of MMP-1 -519A/G have less risk of combined endpoint. The TT variants of -1562C/T MMP-9 and at least one T allele of +92C/T MMP-13 were considered in a trend to affect disease progression and long-term survival after myocardial infarction. According to reclassification analysis NRI and IDI, long-term risk stratification using MMP-1 -422A/T and -519A/G polymorphisms gives additional information to the commonly used GRACE risk score. Patient stratification after myocardial infraction (MI) according to risk genotypes of MMP-1 polymorphisms could have important clinical implications for identification of patients at risk and therapeutic strategies.
ER  -

PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří JARKOVSKÝ, Jolana LIPKOVÁ, Simona LITTNEROVÁ, Martin POLOCZEK, Jindřich ŠPINAR, Lenka KUBKOVÁ, Krystyna KLUZ, Petr KALA, Jan MAŇOUŠEK, Anna VAŠKŮ a Jiří PAŘENICA. Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction. \textit{Journal of Applied Genetics}. Heidelberg: Springer, 2017, roč.~58, č.~3, s.~331-341. ISSN~1234-1983. Dostupné z: https://dx.doi.org/10.1007/s13353-016-0388-8.

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