MicroRNAs Involvement in Radioresistance of Head and Neck
Cancer

J 2017

MicroRNAs Involvement in Radioresistance of Head and Neck Cancer

AHMAD, Parwez, Jiří ŠÁNA, Marek SLAVIK, Pavel SLAMPA, Pavel SMILEK et. al.

Základní údaje

Originální název

MicroRNAs Involvement in Radioresistance of Head and Neck Cancer

Autoři

AHMAD, Parwez (356 Indie, domácí), Jiří ŠÁNA (203 Česká republika, domácí), Marek SLAVIK (203 Česká republika), Pavel SLAMPA (203 Česká republika), Pavel SMILEK (203 Česká republika, domácí) a Ondřej SLABÝ (203 Česká republika, garant, domácí)

Vydání

Disease Markers, London, Hindawi Publishing Corporation, 2017, 0278-0240

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.949

Kód RIV

RIV/00216224:14740/17:00095643

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1155/2017/8245345

UT WoS

000396259800001

Klíčová slova anglicky

SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN NASOPHARYNGEAL CARCINOMA; INCREASES RADIOSENSITIVITY; ENHANCES RADIOSENSITIVITY; IONIZING-RADIATION; GLIOBLASTOMA CELLS; ESOPHAGEAL CANCER; LUNG-CANCER; STEM-CELLS

Štítky

OA, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 2. 2018 13:14, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Resistance to the ionizing radiation is a current problem in the treatment and clinical management of various cancers including head and neck cancer. There are several biological and molecular mechanisms described to be responsible for resistance of the tumors to radiotherapy. Among them, the main mechanisms include alterations in intracellular pathways involved in DNA damage and repair, apoptosis, proliferation, and angiogenesis. It has been found that regulation of these complex processes is often controlled by microRNAs. MicroRNAs are short endogenous RNA molecules that posttranscriptionally modulate gene expression and their deregulated expression has been observed in many tumors including head and neck cancer. Specific expression patterns of microRNAs have also been shown to predict prognosis and therapeutic response in head and neck cancer. Therefore, microRNAs present promising biomarkers and therapeutic targets that might overcome resistance to radiation and improve prognosis of head and neck cancer patients. In this review, we summarize the current knowledge of the functional role of microRNAs in radioresistance of cancer with special focus on head and neck cancer.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NV15-31627A, projekt VaV

Název: Možnosti molekulárně řízené radikální radioterapie nebo radiochemoterapie dle profilu mikroRNA u pacientů se spinocelulárními karcinomy hlavy a krku.

Citovat

AHMAD, Parwez, Jiří ŠÁNA, Marek SLAVIK, Pavel SLAMPA, Pavel SMILEK a Ondřej SLABÝ. MicroRNAs Involvement in Radioresistance of Head and Neck Cancer. Disease Markers. London: Hindawi Publishing Corporation, 2017, roč. 2017, neuvedeno, s. nestránkováno, 8 s. ISSN 0278-0240. Dostupné z: https://dx.doi.org/10.1155/2017/8245345.

@article{1382001,
   author = {Ahmad, Parwez and Šána, Jiří and Slavik, Marek and Slampa, Pavel and Smilek, Pavel and Slabý, Ondřej},
   article_location = {London},
   article_number = {neuvedeno},
   doi = {http://dx.doi.org/10.1155/2017/8245345},
   keywords = {SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN NASOPHARYNGEAL CARCINOMA; INCREASES RADIOSENSITIVITY; ENHANCES RADIOSENSITIVITY; IONIZING-RADIATION; GLIOBLASTOMA CELLS; ESOPHAGEAL CANCER; LUNG-CANCER; STEM-CELLS},
   language = {eng},
   issn = {0278-0240},
   journal = {Disease Markers},
   title = {MicroRNAs Involvement in Radioresistance of Head and Neck Cancer},
   url = {https://www.hindawi.com/journals/dm/2017/8245345/},
   volume = {2017},
   year = {2017}
}

TY  - JOUR
ID  - 1382001
AU  - Ahmad, Parwez - Šána, Jiří - Slavik, Marek - Slampa, Pavel - Smilek, Pavel - Slabý, Ondřej
PY  - 2017
TI  - MicroRNAs Involvement in Radioresistance of Head and Neck Cancer
JF  - Disease Markers
VL  - 2017
IS  - neuvedeno
SP  - nestránkováno
EP  - nestránkováno
PB  - Hindawi Publishing Corporation
SN  - 02780240
KW  - SQUAMOUS-CELL CARCINOMA
KW  - EPITHELIAL-MESENCHYMAL TRANSITION
KW  - HUMAN NASOPHARYNGEAL CARCINOMA
KW  - INCREASES RADIOSENSITIVITY
KW  - ENHANCES RADIOSENSITIVITY
KW  - IONIZING-RADIATION
KW  - GLIOBLASTOMA CELLS
KW  - ESOPHAGEAL CANCER
KW  - LUNG-CANCER
KW  - STEM-CELLS
UR  - https://www.hindawi.com/journals/dm/2017/8245345/
L2  - https://www.hindawi.com/journals/dm/2017/8245345/
N2  - Resistance to the ionizing radiation is a current problem in the treatment and clinical management of various cancers including head and neck cancer. There are several biological and molecular mechanisms described to be responsible for resistance of the tumors to radiotherapy. Among them, the main mechanisms include alterations in intracellular pathways involved in DNA damage and repair, apoptosis, proliferation, and angiogenesis. It has been found that regulation of these complex processes is often controlled by microRNAs. MicroRNAs are short endogenous RNA molecules that posttranscriptionally modulate gene expression and their deregulated expression has been observed in many tumors including head and neck cancer. Specific expression patterns of microRNAs have also been shown to predict prognosis and therapeutic response in head and neck cancer. Therefore, microRNAs present promising biomarkers and therapeutic targets that might overcome resistance to radiation and improve prognosis of head and neck cancer patients. In this review, we summarize the current knowledge of the functional role of microRNAs in radioresistance of cancer with special focus on head and neck cancer.
ER  -

AHMAD, Parwez, Jiří ŠÁNA, Marek SLAVIK, Pavel SLAMPA, Pavel SMILEK a Ondřej SLABÝ. MicroRNAs Involvement in Radioresistance of Head and Neck Cancer. \textit{Disease Markers}. London: Hindawi Publishing Corporation, 2017, roč.~2017, neuvedeno, s.~nestránkováno, 8 s. ISSN~0278-0240. Dostupné z: https://dx.doi.org/10.1155/2017/8245345.

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