MicroRNAs Involvement in Radioresistance of Head and Neck Cancer

AHMAD, Parwez, Jiří ŠÁNA, Marek SLAVIK, Pavel SLAMPA, Pavel SMILEK and Ondřej SLABÝ. MicroRNAs Involvement in Radioresistance of Head and Neck Cancer. Disease Markers. London: Hindawi Publishing Corporation, 2017, vol. 2017, neuvedeno, p. nestránkováno, 8 pp. ISSN 0278-0240. Available from: https://dx.doi.org/10.1155/2017/8245345.

Basic information

• Original name: MicroRNAs Involvement in Radioresistance of Head and Neck Cancer
• Authors: AHMAD, Parwez (356 India, belonging to the institution), Jiří ŠÁNA (203 Czech Republic, belonging to the institution), Marek SLAVIK (203 Czech Republic), Pavel SLAMPA (203 Czech Republic), Pavel SMILEK (203 Czech Republic, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Disease Markers, London, Hindawi Publishing Corporation, 2017, 0278-0240.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.949
• RIV identification code: RIV/00216224:14740/17:00095643
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1155/2017/8245345
• UT WoS: 000396259800001
• Keywords in English: SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN NASOPHARYNGEAL CARCINOMA; INCREASES RADIOSENSITIVITY; ENHANCES RADIOSENSITIVITY; IONIZING-RADIATION; GLIOBLASTOMA CELLS; ESOPHAGEAL CANCER; LUNG-CANCER; STEM-CELLS
• Tags: OA, rivok
• Tags: International impact, Reviewed

Abstract

Resistance to the ionizing radiation is a current problem in the treatment and clinical management of various cancers including head and neck cancer. There are several biological and molecular mechanisms described to be responsible for resistance of the tumors to radiotherapy. Among them, the main mechanisms include alterations in intracellular pathways involved in DNA damage and repair, apoptosis, proliferation, and angiogenesis. It has been found that regulation of these complex processes is often controlled by microRNAs. MicroRNAs are short endogenous RNA molecules that posttranscriptionally modulate gene expression and their deregulated expression has been observed in many tumors including head and neck cancer. Specific expression patterns of microRNAs have also been shown to predict prognosis and therapeutic response in head and neck cancer. Therefore, microRNAs present promising biomarkers and therapeutic targets that might overcome resistance to radiation and improve prognosis of head and neck cancer patients. In this review, we summarize the current knowledge of the functional role of microRNAs in radioresistance of cancer with special focus on head and neck cancer.

Links

• LQ1601, research and development project: Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

• NV15-31627A, research and development project: Name: Možnosti molekulárně řízené radikální radioterapie nebo radiochemoterapie dle profilu mikroRNA u pacientů se spinocelulárními karcinomy hlavy a krku.