J 2017

Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review

HOFER, M, Z HOFEROVA, Daniel DEPEŠ a Martin FALK

Základní údaje

Originální název

Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review

Autoři

HOFER, M, Z HOFEROVA, Daniel DEPEŠ a Martin FALK

Vydání

Molecules, BASEL, Mayer und Muller, 2017, 1420-3049

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 3.098

DOI

UT WoS

000404522900152

Klíčová slova anglicky

acute radiation syndrome; radioprotectors; radiomitigators; combined treatment; cytokines

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 13. 3. 2018 14:04, Mgr. Daniel Depeš

Anotace

V originále

The goal of combined pharmacological approaches in the treatment of the acute radiation syndrome (ARS) is to obtain an effective therapy producing a minimum of undesirable side effects. This review summarizes important data from studies evaluating the efficacy of combining radioprotective agents developed for administration prior to irradiation and therapeutic agents administered in a post-irradiation treatment regimen. Many of the evaluated results show additivity, or even synergism, of the combined treatments in comparison with the effects of the individual component administrations. It can be deduced from these findings that the research in which combined treatments with radioprotectors/ radiomitigators are explored, tested, and evaluated is well-founded. The requirement for studies highly emphasizing the need to minimize undesirable side effects of the radioprotective/ radiomitigating therapies is stressed.