2017
Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review
HOFER, M, Z HOFEROVA, Daniel DEPEŠ a Martin FALKZákladní údaje
Originální název
Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review
Autoři
HOFER, M, Z HOFEROVA, Daniel DEPEŠ a Martin FALK
Vydání
Molecules, BASEL, Mayer und Muller, 2017, 1420-3049
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10601 Cell biology
Stát vydavatele
Švýcarsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 3.098
UT WoS
000404522900152
Klíčová slova anglicky
acute radiation syndrome; radioprotectors; radiomitigators; combined treatment; cytokines
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 13. 3. 2018 14:04, Mgr. Daniel Depeš
Anotace
V originále
The goal of combined pharmacological approaches in the treatment of the acute radiation syndrome (ARS) is to obtain an effective therapy producing a minimum of undesirable side effects. This review summarizes important data from studies evaluating the efficacy of combining radioprotective agents developed for administration prior to irradiation and therapeutic agents administered in a post-irradiation treatment regimen. Many of the evaluated results show additivity, or even synergism, of the combined treatments in comparison with the effects of the individual component administrations. It can be deduced from these findings that the research in which combined treatments with radioprotectors/ radiomitigators are explored, tested, and evaluated is well-founded. The requirement for studies highly emphasizing the need to minimize undesirable side effects of the radioprotective/ radiomitigating therapies is stressed.