SLC22A3 polymorphisms do not modify pancreatic cancer risk, but
may influence overall patient survival

J 2017

SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival

MOHELNIKOVA-DUCHONOVA, Beatrice, Ondrej STROUHAL, David J. HUGHES, Ivana HOLCATOVA, Martin OLIVERIUS et. al.

Základní údaje

Originální název

SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival

Autoři

MOHELNIKOVA-DUCHONOVA, Beatrice (203 Česká republika), Ondrej STROUHAL (203 Česká republika), David J. HUGHES (372 Irsko), Ivana HOLCATOVA (203 Česká republika), Martin OLIVERIUS (203 Česká republika), Zdeněk KALA (203 Česká republika, garant, domácí), Daniele CAMPA (276 Německo), Cosmeri RIZZATO (276 Německo), Federico CANZIAN (276 Německo), Raffaele PEZZILLI (380 Itálie), Renata TALAR-WOJNAROWSKA (616 Polsko), Ewa MALECKA-PANAS (616 Polsko), Cosimo SPERTI (380 Itálie), Carlo Federico ZAMBON (380 Itálie), Serdio PEDRAZZOLI (380 Itálie), Paola FOGAR (380 Itálie), Anna Caterina MILANETTO (380 Itálie), Gabriele CAPURSO (380 Itálie), Giafranco Delle FAVE (380 Itálie), Roberto VALENTE (380 Itálie), Maria GAZOULI (300 Řecko), Giuseppe MALLEO (380 Itálie), Rita Teresa LAWLOR (380 Itálie), Oliver STROBEL (276 Německo), Thilo HACKERT (276 Německo), Nathalia GIESE (276 Německo), Pavel VODICKA (203 Česká republika), Ludmila VODICKOVA (203 Česká republika), Stefano LANDI (380 Itálie), Francesca TAVANO (380 Itálie), Domenica GIOFFREDA (380 Itálie), Ada PIEPOLI (380 Itálie), Valerio PAZIENZA (380 Itálie), Andrea MAMBRINI (380 Itálie), Mariangela PEDATA (380 Itálie), Maurizio CANTORE (380 Itálie), Franco BAMBI (380 Itálie), Stefano ERMINI (380 Itálie), Niccola FUNEL (380 Itálie), Radmila LEMSTROVA (203 Česká republika) a Pavel SOUCEK (203 Česká republika)

Vydání

Scientific Reports, London, Nature Publishing Group, 2017, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.122

Kód RIV

RIV/00216224:14110/17:00096878

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/srep43812

UT WoS

000395686300001

Klíčová slova anglicky

pancreatic cancer

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 3. 2018 16:06, Soňa Böhmová

Anotace

V originále

Expression of the solute carrier (SLC) transporter SLC22A3 gene is associated with overall survival of pancreatic cancer patients. This study tested whether genetic variability in SLC22A3 associates with pancreatic cancer risk and prognosis. Twenty four single nucleotide polymorphisms (SNPs) tagging the SLC22A3 gene sequence and regulatory elements were selected for analysis. Of these, 22 were successfully evaluated in the discovery phase while six significant or suggestive variants entered the validation phase, comprising a total study number of 1,518 cases and 3,908 controls. In the discovery phase, rs2504938, rs9364554, and rs2457571 SNPs were significantly associated with pancreatic cancer risk.

Citovat

MOHELNIKOVA-DUCHONOVA, Beatrice, Ondrej STROUHAL, David J. HUGHES, Ivana HOLCATOVA, Martin OLIVERIUS, Zdeněk KALA, Daniele CAMPA, Cosmeri RIZZATO, Federico CANZIAN, Raffaele PEZZILLI, Renata TALAR-WOJNAROWSKA, Ewa MALECKA-PANAS, Cosimo SPERTI, Carlo Federico ZAMBON, Serdio PEDRAZZOLI, Paola FOGAR, Anna Caterina MILANETTO, Gabriele CAPURSO, Giafranco Delle FAVE, Roberto VALENTE, Maria GAZOULI, Giuseppe MALLEO, Rita Teresa LAWLOR, Oliver STROBEL, Thilo HACKERT, Nathalia GIESE, Pavel VODICKA, Ludmila VODICKOVA, Stefano LANDI, Francesca TAVANO, Domenica GIOFFREDA, Ada PIEPOLI, Valerio PAZIENZA, Andrea MAMBRINI, Mariangela PEDATA, Maurizio CANTORE, Franco BAMBI, Stefano ERMINI, Niccola FUNEL, Radmila LEMSTROVA a Pavel SOUCEK. SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival. Scientific Reports. London: Nature Publishing Group, 2017, roč. 7, č. 43812, s. 1-11. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/srep43812.

@article{1382082,
   author = {MohelnikovaandDuchonova, Beatrice and Strouhal, Ondrej and Hughes, David J. and Holcatova, Ivana and Oliverius, Martin and Kala, Zdeněk and Campa, Daniele and Rizzato, Cosmeri and Canzian, Federico and Pezzilli, Raffaele and TalarandWojnarowska, Renata and MaleckaandPanas, Ewa and Sperti, Cosimo and Zambon, Carlo Federico and Pedrazzoli, Serdio and Fogar, Paola and Milanetto, Anna Caterina and Capurso, Gabriele and Fave, Giafranco Delle and Valente, Roberto and Gazouli, Maria and Malleo, Giuseppe and Lawlor, Rita Teresa and Strobel, Oliver and Hackert, Thilo and Giese, Nathalia and Vodicka, Pavel and Vodickova, Ludmila and Landi, Stefano and Tavano, Francesca and Gioffreda, Domenica and Piepoli, Ada and Pazienza, Valerio and Mambrini, Andrea and Pedata, Mariangela and Cantore, Maurizio and Bambi, Franco and Ermini, Stefano and Funel, Niccola and Lemstrova, Radmila and Soucek, Pavel},
   article_location = {London},
   article_number = {43812},
   doi = {http://dx.doi.org/10.1038/srep43812},
   keywords = {pancreatic cancer},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival},
   volume = {7},
   year = {2017}
}

TY  - JOUR
ID  - 1382082
AU  - Mohelnikova-Duchonova, Beatrice - Strouhal, Ondrej - Hughes, David J. - Holcatova, Ivana - Oliverius, Martin - Kala, Zdeněk - Campa, Daniele - Rizzato, Cosmeri - Canzian, Federico - Pezzilli, Raffaele - Talar-Wojnarowska, Renata - Malecka-Panas, Ewa - Sperti, Cosimo - Zambon, Carlo Federico - Pedrazzoli, Serdio - Fogar, Paola - Milanetto, Anna Caterina - Capurso, Gabriele - Fave, Giafranco Delle - Valente, Roberto - Gazouli, Maria - Malleo, Giuseppe - Lawlor, Rita Teresa - Strobel, Oliver - Hackert, Thilo - Giese, Nathalia - Vodicka, Pavel - Vodickova, Ludmila - Landi, Stefano - Tavano, Francesca - Gioffreda, Domenica - Piepoli, Ada - Pazienza, Valerio - Mambrini, Andrea - Pedata, Mariangela - Cantore, Maurizio - Bambi, Franco - Ermini, Stefano - Funel, Niccola - Lemstrova, Radmila - Soucek, Pavel
PY  - 2017
TI  - SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival
JF  - Scientific Reports
VL  - 7
IS  - 43812
SP  - 1-11
EP  - 1-11
PB  - Nature Publishing Group
SN  - 20452322
KW  - pancreatic cancer
N2  - Expression of the solute carrier (SLC) transporter SLC22A3 gene is associated with overall survival of pancreatic cancer patients. This study tested whether genetic variability in SLC22A3 associates with pancreatic cancer risk and prognosis. Twenty four single nucleotide polymorphisms (SNPs) tagging the SLC22A3 gene sequence and regulatory elements were selected for analysis. Of these, 22 were successfully evaluated in the discovery phase while six significant or suggestive variants entered the validation phase, comprising a total study number of 1,518 cases and 3,908 controls. In the discovery phase, rs2504938, rs9364554, and rs2457571 SNPs were significantly associated with pancreatic cancer risk.
ER  -

MOHELNIKOVA-DUCHONOVA, Beatrice, Ondrej STROUHAL, David J. HUGHES, Ivana HOLCATOVA, Martin OLIVERIUS, Zdeněk KALA, Daniele CAMPA, Cosmeri RIZZATO, Federico CANZIAN, Raffaele PEZZILLI, Renata TALAR-WOJNAROWSKA, Ewa MALECKA-PANAS, Cosimo SPERTI, Carlo Federico ZAMBON, Serdio PEDRAZZOLI, Paola FOGAR, Anna Caterina MILANETTO, Gabriele CAPURSO, Giafranco Delle FAVE, Roberto VALENTE, Maria GAZOULI, Giuseppe MALLEO, Rita Teresa LAWLOR, Oliver STROBEL, Thilo HACKERT, Nathalia GIESE, Pavel VODICKA, Ludmila VODICKOVA, Stefano LANDI, Francesca TAVANO, Domenica GIOFFREDA, Ada PIEPOLI, Valerio PAZIENZA, Andrea MAMBRINI, Mariangela PEDATA, Maurizio CANTORE, Franco BAMBI, Stefano ERMINI, Niccola FUNEL, Radmila LEMSTROVA a Pavel SOUCEK. SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival. \textit{Scientific Reports}. London: Nature Publishing Group, 2017, roč.~7, č.~43812, s.~1-11. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/srep43812.

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