Restrictions in the T-cell repertoire of chronic lymphocytic
leukemia: high-throughput immunoprofiling supports selection by
shared antigenic elements

J 2017

Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements

VARDI, A.; E. VLACHONIKOLA; M. KARYPIDOU; E. STALIKA; Vasileios BIKOS et al.

Základní údaje

Originální název

Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements

Autoři

Vydání

Leukemia, London, Nature Publishing Group, 2017, 0887-6924

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 10.023

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/17:00097384

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

CLONAL EVOLUTION; CONVERGENT RECOMBINATION; TARGETED THERAPIES; MOUSE MODEL; RECEPTORS; LENALIDOMIDE; IBRUTINIB; DRIVEN; CLL; CHEMOIMMUNOTHERAPY

Štítky

MEDGENET, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 2. 2018 16:39, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Immunoglobulin (IG) gene repertoire restrictions strongly support antigen selection in the pathogenesis of chronic lymphocytic leukemia (CLL). Given the emerging multifarious interactions between CLL and bystander T cells, we sought to determine whether antigen(s) are also selecting T cells in CLL. We performed a large-scale, next-generation sequencing (NGS) study of the T-cell repertoire, focusing on major stereotyped subsets representing CLL subgroups with undisputed antigenic drive, but also included patients carrying non-subset IG rearrangements to seek for T-cell immunogenetic signatures ubiquitous in CLL. Considering the inherent limitations of NGS, we deployed bioinformatics algorithms for qualitative curation of T-cell receptor rearrangements, and included multiple types of controls. Overall, we document the clonal architecture of the T-cell repertoire in CLL. These T-cell clones persist and further expand overtime, and can be shared by different patients, most especially patients belonging to the same stereotyped subset. Notably, these shared clonotypes appear to be disease-specific, as they are found in neither public databases nor healthy controls. Altogether, these findings indicate that antigen drive likely underlies T-cell expansions in CLL and may be acting in a CLL subset-specific context. Whether these are the same antigens interacting with the malignant clone or tumor-derived antigens remains to be elucidated.

Návaznosti

LM2011020, projekt VaV

Název: CEITEC ? open access

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC - open access

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Přiložené soubory

vardi2016.pdf Verze souboru

Citovat

VARDI, A.; E. VLACHONIKOLA; M. KARYPIDOU; E. STALIKA; Vasileios BIKOS; K. GEMENETZI; C. MARAMIS; A. SIORENTA; A. ANAGNOSTOPOULOS; Šárka POSPÍŠILOVÁ; N. MAGLAVERAS; I. CHOUVARDA; K. STAMATOPOULOS a A. HADZIDIMITRIOU. Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements. Leukemia. London: Nature Publishing Group, 2017, roč. 31, č. 7, s. 1555-1561. ISSN 0887-6924. Dostupné z: https://doi.org/10.1038/leu.2016.362.

@article{1387845,
   author = {Vardi, A. and Vlachonikola, E. and Karypidou, M. and Stalika, E. and Bikos, Vasileios and Gemenetzi, K. and Maramis, C. and Siorenta, A. and Anagnostopoulos, A. and Pospíšilová, Šárka and Maglaveras, N. and Chouvarda, I. and Stamatopoulos, K. and Hadzidimitriou, A.},
   article_location = {London},
   article_number = {7},
   doi = {https://doi.org/10.1038/leu.2016.362},
   keywords = {CLONAL EVOLUTION; CONVERGENT RECOMBINATION; TARGETED THERAPIES; MOUSE MODEL; RECEPTORS; LENALIDOMIDE; IBRUTINIB; DRIVEN; CLL; CHEMOIMMUNOTHERAPY},
   language = {eng},
   issn = {0887-6924},
   journal = {Leukemia},
   title = {Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements},
   url = {https://www.nature.com/leu/journal/v31/n7/full/leu2016362a.html},
   volume = {31},
   year = {2017}
}

TY  - JOUR
ID  - 1387845
AU  - Vardi, A. - Vlachonikola, E. - Karypidou, M. - Stalika, E. - Bikos, Vasileios - Gemenetzi, K. - Maramis, C. - Siorenta, A. - Anagnostopoulos, A. - Pospíšilová, Šárka - Maglaveras, N. - Chouvarda, I. - Stamatopoulos, K. - Hadzidimitriou, A.
PY  - 2017
TI  - Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements
JF  - Leukemia
VL  - 31
IS  - 7
SP  - 1555-1561
EP  - 1555-1561
PB  - Nature Publishing Group
SN  - 08876924
KW  - CLONAL EVOLUTION
KW  - CONVERGENT RECOMBINATION
KW  - TARGETED THERAPIES
KW  - MOUSE MODEL
KW  - RECEPTORS
KW  - LENALIDOMIDE
KW  - IBRUTINIB
KW  - DRIVEN
KW  - CLL
KW  - CHEMOIMMUNOTHERAPY
UR  - https://www.nature.com/leu/journal/v31/n7/full/leu2016362a.html
L2  - https://www.nature.com/leu/journal/v31/n7/full/leu2016362a.html
N2  - Immunoglobulin (IG) gene repertoire restrictions strongly support antigen selection in the pathogenesis of chronic lymphocytic leukemia (CLL). Given the emerging multifarious interactions between CLL and bystander T cells, we sought to determine whether antigen(s) are also selecting T cells in CLL. We performed a large-scale, next-generation sequencing (NGS) study of the T-cell repertoire, focusing on major stereotyped subsets representing CLL subgroups with undisputed antigenic drive, but also included patients carrying non-subset IG rearrangements to seek for T-cell immunogenetic signatures ubiquitous in CLL. Considering the inherent limitations of NGS, we deployed bioinformatics algorithms for qualitative curation of T-cell receptor rearrangements, and included multiple types of controls. Overall, we document the clonal architecture of the T-cell repertoire in CLL. These T-cell clones persist and further expand overtime, and can be shared by different patients, most especially patients belonging to the same stereotyped subset. Notably, these shared clonotypes appear to be disease-specific, as they are found in neither public databases nor healthy controls. Altogether, these findings indicate that antigen drive likely underlies T-cell expansions in CLL and may be acting in a CLL subset-specific context. Whether these are the same antigens interacting with the malignant clone or tumor-derived antigens remains to be elucidated.
ER  -

VARDI, A.; E. VLACHONIKOLA; M. KARYPIDOU; E. STALIKA; Vasileios BIKOS; K. GEMENETZI; C. MARAMIS; A. SIORENTA; A. ANAGNOSTOPOULOS; Šárka POSPÍŠILOVÁ; N. MAGLAVERAS; I. CHOUVARDA; K. STAMATOPOULOS a A. HADZIDIMITRIOU. Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements. \textit{Leukemia}. London: Nature Publishing Group, 2017, roč.~31, č.~7, s.~1555-1561. ISSN~0887-6924. Dostupné z: https://doi.org/10.1038/leu.2016.362.

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