Luminescent Ruthenium(II) Polypyridyl Complexes as Nonviral
Carriers for DNA Delivery

J 2017

Luminescent Ruthenium(II) Polypyridyl Complexes as Nonviral Carriers for DNA Delivery

BHAT, Satish S., Vidyanand K. REVANKAR, Ayesha KHAN, Rahul V. PINJARI, Marek NEČAS et. al.

Základní údaje

Originální název

Luminescent Ruthenium(II) Polypyridyl Complexes as Nonviral Carriers for DNA Delivery

Autoři

BHAT, Satish S. (356 Indie), Vidyanand K. REVANKAR (356 Indie), Ayesha KHAN (356 Indie), Rahul V. PINJARI (356 Indie) a Marek NEČAS (203 Česká republika, garant, domácí)

Vydání

Chemistry - An Asian Journal, WEINHEIM, WILEY-V C H VERLAG GMBH, 2017, 1861-4728

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10402 Inorganic and nuclear chemistry

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.692

Kód RIV

RIV/00216224:14310/17:00097387

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1002/asia.201601515

UT WoS

000393434200014

Klíčová slova anglicky

DNA; electrochemistry; luminescence; photochemistry; ruthenium

Štítky

CF SAXS, NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 4. 2018 15:28, Ing. Nicole Zrilić

Anotace

V originále

Two new luminescent ruthenium(II) polypyridyl complexes, [Ru(bpy)(2)(tpt-phen)]Cl-2 (1; bpy=2,2'-bipyridine, tpt-phen=triptycenyl-1,10-phenanthroline) and [Ru(phen)(2)(tpt-phen)]Cl-2 (2; phen=1,10-phenanthroline), have been developed as potential nonviral vectors for DNA delivery. Photophysical and electrochemical properties of the complexes have been investigated and corroborated with electronic structure calculations. DNA condensation by these complexes has been investigated by UV/Vis and emission spectroscopy, circular dichroism spectroscopy, atomic force microscopy, dynamic light scattering, confocal microscopy, and electrophoretic mobility studies. These complexes interact with DNA and efficiently condense DNA into globular nanoparticles that are taken up efficiently by HeLa cells. DNA cleavage inability and biocompatibility of complexes have been explored. Both complexes have good gene transfection abilities.

Návaznosti

LM2015043, projekt VaV

Název: Česká infrastruktura pro integrativní strukturní biologii (Akronym: CIISB)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Czech Infrastructure for Integrative Structural Biology

Citovat

BHAT, Satish S., Vidyanand K. REVANKAR, Ayesha KHAN, Rahul V. PINJARI a Marek NEČAS. Luminescent Ruthenium(II) Polypyridyl Complexes as Nonviral Carriers for DNA Delivery. Chemistry - An Asian Journal. WEINHEIM: WILEY-V C H VERLAG GMBH, 2017, roč. 12, č. 2, s. 254-264. ISSN 1861-4728. Dostupné z: https://dx.doi.org/10.1002/asia.201601515.

@article{1387865,
   author = {Bhat, Satish S. and Revankar, Vidyanand K. and Khan, Ayesha and Pinjari, Rahul V. and Nečas, Marek},
   article_location = {WEINHEIM},
   article_number = {2},
   doi = {http://dx.doi.org/10.1002/asia.201601515},
   keywords = {DNA; electrochemistry; luminescence; photochemistry; ruthenium},
   language = {eng},
   issn = {1861-4728},
   journal = {Chemistry - An Asian Journal},
   title = {Luminescent Ruthenium(II) Polypyridyl Complexes as Nonviral Carriers for DNA Delivery},
   volume = {12},
   year = {2017}
}

TY  - JOUR
ID  - 1387865
AU  - Bhat, Satish S. - Revankar, Vidyanand K. - Khan, Ayesha - Pinjari, Rahul V. - Nečas, Marek
PY  - 2017
TI  - Luminescent Ruthenium(II) Polypyridyl Complexes as Nonviral Carriers for DNA Delivery
JF  - Chemistry - An Asian Journal
VL  - 12
IS  - 2
SP  - 254-264
EP  - 254-264
PB  - WILEY-V C H VERLAG GMBH
SN  - 18614728
KW  - DNA
KW  - electrochemistry
KW  - luminescence
KW  - photochemistry
KW  - ruthenium
N2  - Two new luminescent ruthenium(II) polypyridyl complexes, [Ru(bpy)(2)(tpt-phen)]Cl-2 (1; bpy=2,2'-bipyridine, tpt-phen=triptycenyl-1,10-phenanthroline) and [Ru(phen)(2)(tpt-phen)]Cl-2 (2; phen=1,10-phenanthroline), have been developed as potential nonviral vectors for DNA delivery. Photophysical and electrochemical properties of the complexes have been investigated and corroborated with electronic structure calculations. DNA condensation by these complexes has been investigated by UV/Vis and emission spectroscopy, circular dichroism spectroscopy, atomic force microscopy, dynamic light scattering, confocal microscopy, and electrophoretic mobility studies. These complexes interact with DNA and efficiently condense DNA into globular nanoparticles that are taken up efficiently by HeLa cells. DNA cleavage inability and biocompatibility of complexes have been explored. Both complexes have good gene transfection abilities.
ER  -

BHAT, Satish S., Vidyanand K. REVANKAR, Ayesha KHAN, Rahul V. PINJARI a Marek NEČAS. Luminescent Ruthenium(II) Polypyridyl Complexes as Nonviral Carriers for DNA Delivery. \textit{Chemistry - An Asian Journal}. WEINHEIM: WILEY-V C H VERLAG GMBH, 2017, roč.~12, č.~2, s.~254-264. ISSN~1861-4728. Dostupné z: https://dx.doi.org/10.1002/asia.201601515.

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