J 2017

Recent Findings of the Types of Programmed Cell Death

BORYS, Sylwia, Ronza KHOZMI, Wieslawa KRANS, Artur BRYJA, Marta DYSZKIEWICZ-KONWIŃSKA et. al.

Základní údaje

Originální název

Recent Findings of the Types of Programmed Cell Death

Autoři

BORYS, Sylwia (616 Polsko), Ronza KHOZMI (616 Polsko), Wieslawa KRANS (616 Polsko), Artur BRYJA (616 Polsko), Marta DYSZKIEWICZ-KONWIŃSKA (616 Polsko), Michal JEŠETA (203 Česká republika, garant, domácí) a Bartosz KEMPISTY (616 Polsko)

Vydání

Advances in Cell Biology, Warsaw, Polskie towarzystwo anatomiczne, 2017, 0324-833X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.147

Kód RIV

RIV/00216224:14110/17:00097424

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

apoptosis; mitochondrial apoptosis pathway; necrosis; receptor-dependent apotposis; pathway

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 20. 3. 2018 16:29, Soňa Böhmová

Anotace

V originále

Cell death plays an important role in maintaining the homeostasis of multicellular organisms. It can occur in a controlled manner by apoptosis or autophagy. Cell death which occurs regardless of regulatory factors include necrosis, mitotic catastrophe or oncosis. Apoptosis and necrosis are cellular process that leads to cell death. However their mechanisms are different, although factors triggering them can be similar. Necrosis and apoptosis have many different characteristics in terms of biochemistry and morphology. There are two main pathways of apoptosis induction signal: Receptor - dependent and mitochondrial. The outsider apoptotic pathway is induced by external factors stimulating membrane receptors having an intracellular domain called death domain. Mitochondrial apoptotic pathway is activated by increased concentration of reactive oxygen species (ROS), DNA damage, disorders electrolyte transport and an increase in the concentration of the calcium ions in the cytoplasm. In response to stress-factors, mitochondrial channels are opened, so that is released into the cytoplasm cytochrome C. This work is aimed at an overall description of exchanged processes.