J 2017

Locally advanced breast cancer in elderly patients

HORNOVA, Jana, Zbyněk BORTLÍČEK, Petra MÁJKOVÁ, Jitka ABRAHAMOVA, Drahomira KORDIKOVA et. al.

Základní údaje

Originální název

Locally advanced breast cancer in elderly patients

Autoři

HORNOVA, Jana (203 Česká republika), Zbyněk BORTLÍČEK (203 Česká republika, garant, domácí), Petra MÁJKOVÁ (203 Česká republika, domácí), Jitka ABRAHAMOVA (203 Česká republika), Drahomira KORDIKOVA (203 Česká republika), Zuzana DONATOVA (203 Česká republika), Martin KUPEC (203 Česká republika), Ludmila BOUBLIKOVA (203 Česká republika), Josef DVORAK (203 Česká republika), Radek ZAPLETAL (203 Česká republika) a Tomas BUCHLER (203 Česká republika)

Vydání

Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc, Czech Republic, Olomouc, Palacký University, 2017, 1213-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.087

Kód RIV

RIV/00216224:14110/17:00097429

Organizační jednotka

Lékařská fakulta

UT WoS

000406522700014

Klíčová slova anglicky

breast cancer; Charlson score; elderly; retrospective analysis; survival

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 20. 3. 2018 14:04, Soňa Böhmová

Anotace

V originále

Background. Although locally advanced breast cancer (LABC) is more common in the elderly population, there is little data on the clinical characteristics and survival of these patients. The aim of the present study was to compare different factors affecting survival in elderly patients with LABC. Methods. Retrospective analysis was carried out on a cohort of 80 patients aged 70 to 96 years, diagnosed with LABC defined as T3 N1, T4 N0, any N2 or N3, and M0. The prognostic impact of selected clinical parameters including age, comorbidities, tumour grade, HER2 status, tumour stage, local therapies, and systemic treatments was studied. Results. The median age of the patients was 79 years. The majority (n=53; 66%) had at least one significant comorbidity according to the Charlson score evaluation. The median overall survival was 50.6 months. As expected, hormonal therapy was the dominant mode of systemic treatment, but 24% also received at least one line of chemotherapy. Local therapies including surgery and/or radiotherapy were applied in 58% of patients. Conclusions. The diagnosis of LABC in the elderly is associated with poor prognosis. Age and serious comorbidities were negative prognostic factors.