Two highly divergent lineages of exfoliative toxin B-encoding
plasmids revealed in impetigo strains of Staphylococcus aureus

J 2017

Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus

BOTKA, Tibor, Vladislava RŮŽIČKOVÁ, Karla SVOBODOVÁ, Roman PANTŮČEK, Petr PETRÁŠ et. al.

Základní údaje

Originální název

Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus

Autoři

BOTKA, Tibor (203 Česká republika, domácí), Vladislava RŮŽIČKOVÁ (203 Česká republika, garant, domácí), Karla SVOBODOVÁ (203 Česká republika, domácí), Roman PANTŮČEK (203 Česká republika, domácí), Petr PETRÁŠ (203 Česká republika), Darina ČEJKOVÁ (203 Česká republika) a Jiří DOŠKAŘ (203 Česká republika, domácí)

Vydání

International Journal of Medical Microbiology, Jena, ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2017, 1438-4221

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.298

Kód RIV

RIV/00216224:14310/17:00094338

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.ijmm.2017.05.005

UT WoS

000412041100002

Klíčová slova česky

Staphylococcus aureus; exfoliativní toxin B; ETB plazmidy; bulózní impetigo; fylogeneze

Klíčová slova anglicky

Staphylococcus aureus; Exfoliative toxin B; ETB plasmids; Bullous impetigo; Phylogeny

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 4. 2018 16:58, Ing. Nicole Zrilić

Anotace

V originále

Exfoliative toxin B (ETB) encoded by some large plasmids plays a crucial role in epidermolytic diseases caused by Staphylococcus aureus. We have found as yet unknown types of etb gene-positive plasmids isolated from a set of impetigo strains implicated in outbreaks of pemphigus neonatorum in Czech maternity hospitals. Plasmids from the strains of clonal complex CC121 were related to archetypal plasmid pETBTY4. Sharing a 33-kb core sequence including virulence genes for ETB, EDIN C, and lantibiotics, they were assigned to a stand-alone lineage, named pETBTY4-based plasmids. Differing from each other in the content of variable DNA regions, they formed four sequence types. In addition to them, a novel unique plasmid pETB608 isolated from a strain of ST130 was described. Carrying conjugative cluster genes, as well as new variants of etb and edinA genes, pETB608 could be regarded as a source of a new lineage of ETB plasmids. We have designed a helpful detection assay, which facilitates the precise identification of the all described types of ETB plasmids.

Návaznosti

MUNI/A/0967/2015, interní kód MU

Název: Podpora výzkumné činnosti studentů molekulární biologie a genetiky 4 (Akronym: MBG4)

Investor: Masarykova univerzita, Podpora výzkumné činnosti studentů molekulární biologie a genetiky 4, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

QJ1510216, projekt VaV

Název: Fágová terapie infekcí vyvolaných Staphylococcus aureus v chovech hospodářských zvířat (Akronym: StafyFag)

Investor: Ministerstvo zemědělství ČR, Fágová terapie infekcí vyvolaných Staphylococcus aureus v chovech hospodářských zvířat

Přiložené soubory

1-s2.0-S1438422117301157-main.pdf

Požádat o autorskou verzi souboru

Citovat

BOTKA, Tibor, Vladislava RŮŽIČKOVÁ, Karla SVOBODOVÁ, Roman PANTŮČEK, Petr PETRÁŠ, Darina ČEJKOVÁ a Jiří DOŠKAŘ. Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus. International Journal of Medical Microbiology. Jena: ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2017, roč. 307, č. 6, s. 291-296. ISSN 1438-4221. Dostupné z: https://dx.doi.org/10.1016/j.ijmm.2017.05.005.

@article{1389107,
   author = {Botka, Tibor and Růžičková, Vladislava and Svobodová, Karla and Pantůček, Roman and Petráš, Petr and Čejková, Darina and Doškař, Jiří},
   article_location = {Jena},
   article_number = {6},
   doi = {http://dx.doi.org/10.1016/j.ijmm.2017.05.005},
   keywords = {Staphylococcus aureus; Exfoliative toxin B; ETB plasmids; Bullous impetigo; Phylogeny},
   language = {eng},
   issn = {1438-4221},
   journal = {International Journal of Medical Microbiology},
   title = {Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus},
   url = {http://www.sciencedirect.com/science/article/pii/S1438422117301157},
   volume = {307},
   year = {2017}
}

TY  - JOUR
ID  - 1389107
AU  - Botka, Tibor - Růžičková, Vladislava - Svobodová, Karla - Pantůček, Roman - Petráš, Petr - Čejková, Darina - Doškař, Jiří
PY  - 2017
TI  - Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus
JF  - International Journal of Medical Microbiology
VL  - 307
IS  - 6
SP  - 291-296
EP  - 291-296
PB  - ELSEVIER GMBH, URBAN & FISCHER VERLAG
SN  - 14384221
KW  - Staphylococcus aureus
KW  - Exfoliative toxin B
KW  - ETB plasmids
KW  - Bullous impetigo
KW  - Phylogeny
UR  - http://www.sciencedirect.com/science/article/pii/S1438422117301157
L2  - http://www.sciencedirect.com/science/article/pii/S1438422117301157
N2  - Exfoliative toxin B (ETB) encoded by some large plasmids plays a crucial role in epidermolytic diseases caused by Staphylococcus aureus. We have found as yet unknown types of etb gene-positive plasmids isolated from a set of impetigo strains implicated in outbreaks of pemphigus neonatorum in Czech maternity hospitals. Plasmids from the strains of clonal complex CC121 were related to archetypal plasmid pETBTY4. Sharing a 33-kb core sequence including virulence genes for ETB, EDIN C, and lantibiotics, they were assigned to a stand-alone lineage, named pETBTY4-based plasmids. Differing from each other in the content of variable DNA regions, they formed four sequence types. In addition to them, a novel unique plasmid pETB608 isolated from a strain of ST130 was described. Carrying conjugative cluster genes, as well as new variants of etb and edinA genes, pETB608 could be regarded as a source of a new lineage of ETB plasmids. We have designed a helpful detection assay, which facilitates the precise identification of the all described types of ETB plasmids.
ER  -

BOTKA, Tibor, Vladislava RŮŽIČKOVÁ, Karla SVOBODOVÁ, Roman PANTŮČEK, Petr PETRÁŠ, Darina ČEJKOVÁ a Jiří DOŠKAŘ. Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus. \textit{International Journal of Medical Microbiology}. Jena: ELSEVIER GMBH, URBAN \&{} FISCHER VERLAG, 2017, roč.~307, č.~6, s.~291-296. ISSN~1438-4221. Dostupné z: https://dx.doi.org/10.1016/j.ijmm.2017.05.005.

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