2017
Modified posterior pelvic exenteration for advanced ovarian malignancies: a single-institution study of 35 cases
MINÁŘ, Luboš, Michal FELSINGER, Ivo ROVNÝ, Filip ZLÁMAL, Julie BIENERTOVÁ VAŠKŮ et. al.Základní údaje
Originální název
Modified posterior pelvic exenteration for advanced ovarian malignancies: a single-institution study of 35 cases
Autoři
MINÁŘ, Luboš (203 Česká republika, garant, domácí), Michal FELSINGER (203 Česká republika), Ivo ROVNÝ (203 Česká republika), Filip ZLÁMAL (203 Česká republika, domácí), Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, domácí) a Eva JANDÁKOVÁ (203 Česká republika)
Vydání
Acta Obstetricia et Gynecologica Scandinavica, Hoboken, Brill, 2017, 0001-6349
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30214 Obstetrics and gynaecology
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 2.649
Kód RIV
RIV/00216224:14110/17:00097520
Organizační jednotka
Lékařská fakulta
UT WoS
000407745700015
Klíčová slova anglicky
Advanced ovarian cancer; modified posterior pelvic exenteration; residual disease; disease-free survival; surgical complications
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 18. 3. 2018 17:05, Soňa Böhmová
Anotace
V originále
IntroductionThis study aimed to investigate the possible benefits of a complete cytoreduction in patients with advanced ovarian cancer and concomitant rectal invasion. Furthermore, we evaluated the morbidity associated with radical surgery. Material and methodsA retrospective analysis examined 35 women who underwent radical surgery in the form of modified posterior pelvic exenteration. Descriptive statistics, Kaplan-Meier survival curves and log-rank test were used for statistical estimations. Surgical complications were analyzed using the Clavien-Dindo classification. ResultsThe analysis of survival in relation to residual disease assessed according to Sugarbaker confirmed an optimistic prognosis in patients with optimal debulking with a mean disease-free survival period of 33.6 months in R0 patients, 19.6 months in R1 patients, and 14.3 months in R2 patients. A statistically significant difference in disease-free survival (p = 0.023) was observed between the R0 (without residual disease) and R1+2 (with residual disease) groups. Surgical complications occurred in 83% of patients, with early postoperative complications being most frequent (65.7%). While grade III-IV complications occurred in 37.7% of all patients, no cases of surgery-associated mortality occurred. ConclusionsModified posterior pelvic exenteration is a highly effective method for achieving optimal debulking in cases of advanced ovarian cancer with the direct invasion of the rectum. Modified posterior pelvic exenteration does not delay the beginning of complementary chemotherapy. However, it is necessary to take into account surgery-related morbidity. As modified posterior pelvic exenteration represents an extremely invasive technique, the surgical plan and perioperative care should be personalized to address the individual medical and surgical conditions of each patient.