| MANAKHOV, Anton, Eva DVOŘÁKOVÁ, Jiřina MEDALOVÁ, Petra ČERNOCHOVÁ, Adam OBRUSNÍK, Miroslav MICHLÍČEK, Dmitry V. SHTANSKY and Lenka ZAJÍČKOVÁ. Carboxyl-anhydride and amine plasma coating of PCL nanofibers to improve their bioactivity. MATERIALS & DESIGN. OXFORD: ELSEVIER SCI LTD, 2017, vol. 132, October, p. 257-265. ISSN 0264-1275. Available from: https://dx.doi.org/10.1016/j.matdes.2017.06.057. |
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@article{1389322,
author = {Manakhov, Anton and Dvořáková, Eva and Medalová, Jiřina and Černochová, Petra and Obrusník, Adam and Michlíček, Miroslav and Shtansky, Dmitry V. and Zajíčková, Lenka},
article_location = {OXFORD},
article_number = {October},
doi = {http://dx.doi.org/10.1016/j.matdes.2017.06.057},
keywords = {PCL nanofibers; Plasma polymerization; Cell viability; Amine surfaces; Carboxyl-anhydride layers},
language = {eng},
issn = {0264-1275},
journal = {MATERIALS & DESIGN},
title = {Carboxyl-anhydride and amine plasma coating of PCL nanofibers to improve their bioactivity},
url = {http://www.sciencedirect.com/science/article/pii/S0264127517306469},
volume = {132},
year = {2017}
}
TY - JOUR
ID - 1389322
AU - Manakhov, Anton - Dvořáková, Eva - Medalová, Jiřina - Černochová, Petra - Obrusník, Adam - Michlíček, Miroslav - Shtansky, Dmitry V. - Zajíčková, Lenka
PY - 2017
TI - Carboxyl-anhydride and amine plasma coating of PCL nanofibers to improve their bioactivity
JF - MATERIALS & DESIGN
VL - 132
IS - October
SP - 257-265
EP - 257-265
PB - ELSEVIER SCI LTD
SN - 02641275
KW - PCL nanofibers
KW - Plasma polymerization
KW - Cell viability
KW - Amine surfaces
KW - Carboxyl-anhydride layers
UR - http://www.sciencedirect.com/science/article/pii/S0264127517306469
L2 - http://www.sciencedirect.com/science/article/pii/S0264127517306469
N2 - The plasmamodification of biodegradable nanofibers is of great interest for improvement of their biocompatibility. However, there are no systematic studies regarding the influence of plasma polymer deposition onto the surface of nanofibers to improve cell adhesion. In the present study, homogenous and reproducible modification of polycaprolactone (PCL) nanofibers by amine and carboxyl/anhydride groupswas achieved. The concentration of amines NH2/C and C(O)O contribution were up to 2.9 and 14.1%, respectively. Regardless the plasma conditions, the deposition of amine and carboxyl-anhydride plasma coatings onto the PCL nanofibers sufficiently improved the cell adhesion and viability, as was evidenced by microscopy observations and ATP assay results. It should be emphasized that the deposition of negatively charged carboxyl-anhydride coatings resulted in slightly better cell adhesion compared to the positively charged amine plasma coatings, unlike the widespread opinion that COOH modification has less effect on myoblasts adhesion. (C) 2017 Elsevier Ltd. All rights reserved.
ER -
MANAKHOV, Anton, Eva DVOŘÁKOVÁ, Jiřina MEDALOVÁ, Petra ČERNOCHOVÁ, Adam OBRUSNÍK, Miroslav MICHLÍČEK, Dmitry V. SHTANSKY and Lenka ZAJÍČKOVÁ. Carboxyl-anhydride and amine plasma coating of PCL nanofibers to improve their bioactivity. \textit{MATERIALS \&{} DESIGN}. OXFORD: ELSEVIER SCI LTD, 2017, vol.~132, October, p.~257-265. ISSN~0264-1275. Available from: https://dx.doi.org/10.1016/j.matdes.2017.06.057.
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