FATHALLA, Walid Mohamed and Pavel PAZDERA. Convenient Synthesis of Piperazine Substituted Quinolones. Online. Journal of Heterocyclic Chemistry. Hoboken, NJ USA: Wiley, 2017, vol. 54, No 6, p. 3481-3489. ISSN 0022-152X. Available from: https://dx.doi.org/10.1002/jhet.2971. [citováno 2024-04-23]
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Basic information
Original name Convenient Synthesis of Piperazine Substituted Quinolones
Name in Czech Convenient Synthesis of Piperazine Substituted Quinolones
Authors FATHALLA, Walid Mohamed (818 Egypt) and Pavel PAZDERA (203 Czech Republic, guarantor, belonging to the institution)
Edition Journal of Heterocyclic Chemistry, Hoboken, NJ USA, Wiley, 2017, 0022-152X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10401 Organic chemistry
Country of publisher Japan
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.141
RIV identification code RIV/00216224:14310/17:00097590
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1002/jhet.2971
UT WoS 000422654000060
Keywords in English N1-monosubstituted piperazine; Linomide; Quinolones;Azide coupling method; Amino acids
Tags NZ, rivok
Changed by Changed by: Ing. Nicole Zrilić, učo 240776. Changed: 3/4/2018 11:31.
Abstract
A series of 1-[(4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinolin-3-yl)carbonyl]-4-(substituted) piperazines 3a–c and methyl 2-[(4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinolin-3-yl)carbonylamino] alkanoates 5a–d has been developed by the direct condensation of ethyl [4-hydroxy-2-oxo-1-phenyl-1,2-dihydro-3-quinoline] carboxylate 2 with N1-monosubstituted piperazine hydrochlorides or amino acid ester hydrochloride in the presence of triethyl amine. The quinolone amino acid esters 5a–d were the key intermediate for the preparation of a series of 1-[2-((4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinolin-3-yl)carbonylamino)alkylcarbony]-4-substituted piperazine derivatives 8–11 (a-d) via azide coupling method with amino acid ester hydrochloride.
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