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@article{1390845,
author = {Keegan, Liam and Khan, Anzer and Vukić, Dragana and O'Connell, Mary},
article_location = {COLD SPRING HARBOR},
article_number = {9},
doi = {http://dx.doi.org/10.1261/rna.060921},
keywords = {ADAR; Drosophila melanogaster; RNA editing; dsRNA; RNA modification; epitranscriptome},
language = {eng},
issn = {1355-8382},
journal = {RNA},
title = {ADAR RNA editing below the backbone},
url = {http://rnajournal.cshlp.org/content/early/2017/05/30/rna.060921.117.abstract},
volume = {23},
year = {2017}
}
TY - JOUR
ID - 1390845
AU - Keegan, Liam - Khan, Anzer - Vukić, Dragana - O'Connell, Mary
PY - 2017
TI - ADAR RNA editing below the backbone
JF - RNA
VL - 23
IS - 9
SP - 1317-1328
EP - 1317-1328
PB - COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
SN - 13558382
KW - ADAR
KW - Drosophila melanogaster
KW - RNA editing
KW - dsRNA
KW - RNA modification
KW - epitranscriptome
UR - http://rnajournal.cshlp.org/content/early/2017/05/30/rna.060921.117.abstract
L2 - http://rnajournal.cshlp.org/content/early/2017/05/30/rna.060921.117.abstract
N2 - ADAR RNA editing enzymes (adenosine deaminases acting on RNA) that convert adenosine bases to inosines were first identified biochemically 30 years ago. Since then, studies on ADARs in genetic model organisms, and evolutionary comparisons between them, continue to reveal a surprising range of pleiotropic biological effects of ADARs. This review focuses on Drosophila melanogaster, which has a single Adar gene encoding a homolog of vertebrate ADAR2 that site-specifically edits hundreds of transcripts to change individual codons in ion channel subunits and membrane and cytoskeletal proteins. Drosophila ADAR is involved in the control of neuronal excitability and neurodegeneration and, intriguingly, in the control of neuronal plasticity and sleep. Drosophila ADAR also interacts strongly with RNA interference, a key antiviral defense mechanism in invertebrates. Recent crystal structures of human ADAR2 deaminase domain-RNA complexes help to interpret available information on Drosophila ADAR isoforms and on the evolution of ADARs from tRNA deaminase ADAT proteins. ADAR RNA editing is a paradigm for the now rapidly expanding range of RNA modifications in mRNAs and ncRNAs. Even with recent progress, much remains to be understood about these groundbreaking ADAR RNA modification systems.
ER -
KEEGAN, Liam, Anzer KHAN, Dragana VUKI$\backslash$'C a Mary O'CONNELL. ADAR RNA editing below the backbone. \textit{RNA}. COLD SPRING HARBOR: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 2017, roč.~23, č.~9, s.~1317-1328. ISSN~1355-8382. Dostupné z: https://dx.doi.org/10.1261/rna.060921.
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