JIANG, LY, P DZIEDZIC, Zdeněk SPÁČIL, GL ZHAO, L NILSSON, LL ILAG a A CORDOVA. Abiotic synthesis of amino acids and self-crystallization under prebiotic conditions. Scientific Reports. LONDON: NATURE PUBLISHING GROUP, 2014, roč. 4, 6 s. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/srep06769.
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Základní údaje
Originální název Abiotic synthesis of amino acids and self-crystallization under prebiotic conditions
Autoři JIANG, LY, P DZIEDZIC, Zdeněk SPÁČIL, GL ZHAO, L NILSSON, LL ILAG a A CORDOVA.
Vydání Scientific Reports, LONDON, NATURE PUBLISHING GROUP, 2014, 2045-2322.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 5.578
Doi http://dx.doi.org/10.1038/srep06769
UT WoS 000343978700001
Změnil Změnil: PharmDr. Zdeněk Spáčil, Ph.D., učo 238088. Změněno: 29. 9. 2017 13:44.
Anotace
Building on previous research on the origin and homochirality of life, this study focuses on analyses profiling important building blocks of life: the natural amino acids. The spark discharge variation of the iconic Miller experiment was performed with a reducing gas mixture of ammonia, methane, water and hydrogen. Amino acid analysis using liquid chromatography coupled with tandem mass spectrometry after pre-column derivatizaiton revealed the generation of several amino acids including those essential for life. Re-crystallization of the synthetic products and enantiomeric ratio analysis were subsequently performed. Results from liquid chromatography coupled with either fluorescent detector or tandem mass spectrometry after pre-column derivatization with chiral reagent revealed spontaneous and effective asymmetric resolution of serine and alanine. This work describes a useful analytical platform for investigation of hypotheses regarding the origin and homochirality of amino acids under prebiotic conditions. The formation of numerous amino acids in the electric discharge experiment and the occurrence of high enantiomeric ratios of amino acids in re-crystallization experiment give valuable implications for future studies in unraveling fundamental questions regarding origins and evolution of life.
VytisknoutZobrazeno: 25. 6. 2024 17:52