Transfer of a cyanobacterial neurotoxin within a temperate
aquatic ecosystem suggests pathways for human exposure

J 2010

Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure

JONASSON, S, J ERIKSSON, L BERNTZON, Zdeněk SPÁČIL, LL ILAG et. al.

Basic information

Original name

Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure

Authors

JONASSON, S, J ERIKSSON, L BERNTZON, Zdeněk SPÁČIL, LL ILAG, LO RONNEVI, U RASMUSSEN and B BERGMAN

Edition

Proceedings of the National Academy of Sciences of the United States of America, WASHINGTON, National Academy of Sciences, 2010, 0027-8424

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 9.771

DOI

http://dx.doi.org/10.1073/pnas.0914417107

UT WoS

000277822600043

Keywords in English

beta-methylamino-L-alanine; Baltic Sea; cyanobacteria; liquid chromatography/mass spectrometry; bioaccumulation

Změněno: 29/9/2017 13:53, PharmDr. Zdeněk Spáčil, Ph.D.

Abstract

V originále

beta-methylamino-L-alanine (BMAA), a neurotoxic nonprotein amino acid produced by most cyanobacteria, has been proposed to be the causative agent of devastating neurodegenerative diseases on the island of Guam in the Pacific Ocean. Because cyanobacteria are widespread globally, we hypothesized that BMAA might occur and bioaccumulate in other ecosystems. Here we demonstrate, based on a recently developed extraction and HPLC-MS/MS method and long-term monitoring of BMAA in cyanobacterial populations of a temperate aquatic ecosystem (Baltic Sea, 2007-2008), that BMAA is biosynthesized by cyanobacterial genera dominating the massive surface blooms of this water body. BMAA also was found at higher concentrations in organisms of higher trophic levels that directly or indirectly feed on cyanobacteria, such as zooplankton and various vertebrates (fish) and invertebrates (mussels, oysters). Pelagic and benthic fish species used for human consumption were included. The highest BMAA levels were detected in the muscle and brain of bottom-dwelling fishes. The discovery of regular biosynthesis of the neurotoxin BMAA in a large temperate aquatic ecosystem combined with its possible transfer and bioaccumulation within major food webs, some ending in human consumption, is alarming and requires attention.

Citovat

JONASSON, S, J ERIKSSON, L BERNTZON, Zdeněk SPÁČIL, LL ILAG, LO RONNEVI, U RASMUSSEN and B BERGMAN. Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure. Proceedings of the National Academy of Sciences of the United States of America. WASHINGTON: National Academy of Sciences, 2010, vol. 107, No 20, p. 9252-9257. ISSN 0027-8424. Available from: https://dx.doi.org/10.1073/pnas.0914417107.

@article{1391012,
   author = {Jonasson, S and Eriksson, J and Berntzon, L and Spáčil, Zdeněk and Ilag, LL and Ronnevi, LO and Rasmussen, U and Bergman, B},
   article_location = {WASHINGTON},
   article_number = {20},
   doi = {http://dx.doi.org/10.1073/pnas.0914417107},
   keywords = {beta-methylamino-L-alanine; Baltic Sea; cyanobacteria; liquid chromatography/mass spectrometry; bioaccumulation},
   language = {eng},
   issn = {0027-8424},
   journal = {Proceedings of the National Academy of Sciences of the United States of America},
   title = {Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure},
   volume = {107},
   year = {2010}
}

TY  - JOUR
ID  - 1391012
AU  - Jonasson, S - Eriksson, J - Berntzon, L - Spáčil, Zdeněk - Ilag, LL - Ronnevi, LO - Rasmussen, U - Bergman, B
PY  - 2010
TI  - Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure
JF  - Proceedings of the National Academy of Sciences of the United States of America
VL  - 107
IS  - 20
SP  - 9252-9257
EP  - 9252-9257
PB  - National Academy of Sciences
SN  - 00278424
KW  - beta-methylamino-L-alanine
KW  - Baltic Sea
KW  - cyanobacteria
KW  - liquid chromatography/mass spectrometry
KW  - bioaccumulation
N2  - beta-methylamino-L-alanine (BMAA), a neurotoxic nonprotein amino acid produced by most cyanobacteria, has been proposed to be the causative agent of devastating neurodegenerative diseases on the island of Guam in the Pacific Ocean. Because cyanobacteria are widespread globally, we hypothesized that BMAA might occur and bioaccumulate in other ecosystems. Here we demonstrate, based on a recently developed extraction and HPLC-MS/MS method and long-term monitoring of BMAA in cyanobacterial populations of a temperate aquatic ecosystem (Baltic Sea, 2007-2008), that BMAA is biosynthesized by cyanobacterial genera dominating the massive surface blooms of this water body. BMAA also was found at higher concentrations in organisms of higher trophic levels that directly or indirectly feed on cyanobacteria, such as zooplankton and various vertebrates (fish) and invertebrates (mussels, oysters). Pelagic and benthic fish species used for human consumption were included. The highest BMAA levels were detected in the muscle and brain of bottom-dwelling fishes. The discovery of regular biosynthesis of the neurotoxin BMAA in a large temperate aquatic ecosystem combined with its possible transfer and bioaccumulation within major food webs, some ending in human consumption, is alarming and requires attention.
ER  -

JONASSON, S, J ERIKSSON, L BERNTZON, Zdeněk SPÁČIL, LL ILAG, LO RONNEVI, U RASMUSSEN and B BERGMAN. Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure. \textit{Proceedings of the National Academy of Sciences of the United States of America}. WASHINGTON: National Academy of Sciences, 2010, vol.~107, No~20, p.~9252-9257. ISSN~0027-8424. Available from: https://dx.doi.org/10.1073/pnas.0914417107.

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